1P8X

The Calcium-Activated C-terminal half of gelsolin

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0051015	molecular_function	actin filament binding
B	0051015	molecular_function	actin filament binding
C	0051015	molecular_function	actin filament binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA A 1001

Chain	Residue
A	GLY444
A	ASP445
A	GLU475
A	THR524
A	HOH1110
A	HOH1111

---

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA A 1002

Chain	Residue
A	HOH1193
A	HOH1194
A	ASN564
A	ASP565
A	GLU587

---

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA A 1003

Chain	Residue
A	ASP669
A	ASP670
A	GLU692
A	HOH1258
A	HOH1259
A	HOH1260

---

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA B 1001

Chain	Residue
B	GLY444
B	ASP445
B	GLU475
B	THR524
B	HOH1115
B	HOH1119

---

site_id	AC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA B 1002

Chain	Residue
B	ASN564
B	ASP565
B	GLU587
B	HOH1155
B	HOH1156

---

site_id	AC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA B 1003

Chain	Residue
B	ASP669
B	ASP670
B	GLU692
B	HOH1217
B	HOH1222
B	HOH1223

---

site_id	AC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA C 1001

Chain	Residue
C	GLY444
C	ASP445
C	GLU475
C	THR524
C	HOH1119
C	HOH1167

---

site_id	AC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA C 1002

Chain	Residue
C	ASN564
C	ASP565
C	GLU587
C	HOH1188
C	HOH1308

---

site_id	AC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA C 1003

Chain	Residue
C	ASP669
C	ASP670
C	GLU692
C	HOH1269
C	HOH1270
C	HOH1271

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	81
Details	Repeat: {"description":"Gelsolin-like 4","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	198
Details	Repeat: {"description":"Gelsolin-like 5","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"12460571","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16466744","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1H1V","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2FH2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2FH3","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	21
Details	Binding site: {"evidences":[{"source":"PubMed","id":"12460571","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16466744","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1H1V","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2FH1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2FH2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2FH3","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	9
Details	Binding site: {"evidences":[{"source":"PubMed","id":"12460571","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1H1V","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"12460571","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16466744","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1H1V","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2FH3","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	3
Details	Modified residue: {"description":"Phosphotyrosine; by SRC","evidences":[{"source":"PubMed","id":"10210201","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	3
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"P13020","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	6
Details	Modified residue: {"description":"Phosphotyrosine; by SRC; in vitro","evidences":[{"source":"PubMed","id":"10210201","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	3
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	150
Details	Repeat: {"description":"Gelsolin-like 6","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---