1P84
HDBT inhibited Yeast Cytochrome bc1 Complex
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004222 | molecular_function | metalloendopeptidase activity |
A | 0005515 | molecular_function | protein binding |
A | 0005739 | cellular_component | mitochondrion |
A | 0005743 | cellular_component | mitochondrial inner membrane |
A | 0006122 | biological_process | mitochondrial electron transport, ubiquinol to cytochrome c |
A | 0006627 | biological_process | protein processing involved in protein targeting to mitochondrion |
A | 0008121 | molecular_function | ubiquinol-cytochrome-c reductase activity |
A | 0009060 | biological_process | aerobic respiration |
A | 0045275 | cellular_component | respiratory chain complex III |
A | 0045333 | biological_process | cellular respiration |
A | 0046872 | molecular_function | metal ion binding |
A | 1902600 | biological_process | proton transmembrane transport |
B | 0004222 | molecular_function | metalloendopeptidase activity |
B | 0005515 | molecular_function | protein binding |
B | 0005739 | cellular_component | mitochondrion |
B | 0005743 | cellular_component | mitochondrial inner membrane |
B | 0006122 | biological_process | mitochondrial electron transport, ubiquinol to cytochrome c |
B | 0006508 | biological_process | proteolysis |
B | 0008121 | molecular_function | ubiquinol-cytochrome-c reductase activity |
B | 0009060 | biological_process | aerobic respiration |
B | 0030061 | cellular_component | mitochondrial crista |
B | 0045275 | cellular_component | respiratory chain complex III |
B | 0045333 | biological_process | cellular respiration |
B | 0046872 | molecular_function | metal ion binding |
B | 1902600 | biological_process | proton transmembrane transport |
C | 0005739 | cellular_component | mitochondrion |
C | 0005743 | cellular_component | mitochondrial inner membrane |
C | 0006122 | biological_process | mitochondrial electron transport, ubiquinol to cytochrome c |
C | 0008121 | molecular_function | ubiquinol-cytochrome-c reductase activity |
C | 0009055 | molecular_function | electron transfer activity |
C | 0009060 | biological_process | aerobic respiration |
C | 0016020 | cellular_component | membrane |
C | 0016491 | molecular_function | oxidoreductase activity |
C | 0022904 | biological_process | respiratory electron transport chain |
C | 0045275 | cellular_component | respiratory chain complex III |
C | 0045333 | biological_process | cellular respiration |
C | 0046872 | molecular_function | metal ion binding |
C | 1902600 | biological_process | proton transmembrane transport |
D | 0009055 | molecular_function | electron transfer activity |
D | 0020037 | molecular_function | heme binding |
E | 0008121 | molecular_function | ubiquinol-cytochrome-c reductase activity |
E | 0016020 | cellular_component | membrane |
E | 0051537 | molecular_function | 2 iron, 2 sulfur cluster binding |
G | 0005739 | cellular_component | mitochondrion |
G | 0005743 | cellular_component | mitochondrial inner membrane |
G | 0006122 | biological_process | mitochondrial electron transport, ubiquinol to cytochrome c |
G | 0008121 | molecular_function | ubiquinol-cytochrome-c reductase activity |
G | 0009060 | biological_process | aerobic respiration |
G | 0034551 | biological_process | mitochondrial respiratory chain complex III assembly |
G | 0045275 | cellular_component | respiratory chain complex III |
G | 0045333 | biological_process | cellular respiration |
G | 0099617 | cellular_component | matrix side of mitochondrial inner membrane |
G | 1902600 | biological_process | proton transmembrane transport |
H | 0005739 | cellular_component | mitochondrion |
H | 0005743 | cellular_component | mitochondrial inner membrane |
H | 0006122 | biological_process | mitochondrial electron transport, ubiquinol to cytochrome c |
H | 0008121 | molecular_function | ubiquinol-cytochrome-c reductase activity |
H | 0009060 | biological_process | aerobic respiration |
H | 0045275 | cellular_component | respiratory chain complex III |
H | 0045333 | biological_process | cellular respiration |
H | 1902600 | biological_process | proton transmembrane transport |
I | 0006122 | biological_process | mitochondrial electron transport, ubiquinol to cytochrome c |
I | 0045275 | cellular_component | respiratory chain complex III |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 16 |
Details | BINDING SITE FOR RESIDUE HEC C 701 |
Chain | Residue |
C | LEU40 |
C | GLY131 |
C | VAL135 |
C | HIS183 |
C | TYR184 |
C | PRO187 |
C | HOH729 |
C | HOH739 |
C | GLN43 |
C | GLY47 |
C | MET50 |
C | ARG79 |
C | HIS82 |
C | PHE89 |
C | THR127 |
C | ALA128 |
site_id | AC2 |
Number of Residues | 18 |
Details | BINDING SITE FOR RESIDUE HEC C 702 |
Chain | Residue |
C | TRP30 |
C | GLY33 |
C | LEU36 |
C | HIS96 |
C | MET97 |
C | LYS99 |
C | SER105 |
C | LEU113 |
C | GLY117 |
C | ILE120 |
C | VAL194 |
C | HIS197 |
C | LEU201 |
C | SER206 |
C | SER207 |
C | UQ6706 |
C | HOH713 |
C | HOH730 |
site_id | AC3 |
Number of Residues | 13 |
Details | BINDING SITE FOR RESIDUE HEC D 703 |
Chain | Residue |
D | VAL100 |
D | CYS101 |
D | CYS104 |
D | HIS105 |
D | ARG184 |
D | TYR190 |
D | ILE191 |
D | PHE218 |
D | ILE223 |
D | ALA224 |
D | MET225 |
D | VAL228 |
D | HOH739 |
site_id | AC4 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE FES E 704 |
Chain | Residue |
E | CYS159 |
E | HIS161 |
E | LEU162 |
E | CYS178 |
E | HIS181 |
E | SER183 |
site_id | AC5 |
Number of Residues | 9 |
Details | BINDING SITE FOR RESIDUE DBT C 705 |
Chain | Residue |
C | MET139 |
C | GLY143 |
C | VAL146 |
C | ILE147 |
C | ILE269 |
C | PRO271 |
C | TYR279 |
C | HOH790 |
E | HIS181 |
site_id | AC6 |
Number of Residues | 12 |
Details | BINDING SITE FOR RESIDUE UQ6 C 706 |
Chain | Residue |
C | TYR16 |
C | GLN22 |
C | ILE26 |
C | SER34 |
C | ILE44 |
C | LEU201 |
C | SER206 |
C | MET221 |
C | ASP229 |
C | HEC702 |
C | HOH721 |
C | HOH802 |
site_id | AC7 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE 3PE C 710 |
Chain | Residue |
C | TRP29 |
C | MET97 |
C | TYR102 |
C | TYR103 |
C | TYR359 |
G | GLU82 |
H | ARG51 |
H | PHE52 |
site_id | AC8 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE 3PE C 711 |
Chain | Residue |
C | PHE3 |
C | ASN7 |
C | TYR9 |
C | VAL13 |
C | THR112 |
C | ASN115 |
C | HOH779 |
site_id | AC9 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE 3PH A 713 |
Chain | Residue |
A | SER450 |
A | UMQ721 |
A | HOH775 |
C | LEU230 |
D | 3PH714 |
E | VAL60 |
E | SER67 |
site_id | BC1 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE 3PH D 714 |
Chain | Residue |
D | THR273 |
D | ILE276 |
E | GLY70 |
E | SER73 |
A | 3PH713 |
C | MET237 |
D | LYS272 |
site_id | BC2 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE PC1 D 715 |
Chain | Residue |
C | HIS253 |
C | SER268 |
C | TRP273 |
C | GLY337 |
D | HIS185 |
D | HOH792 |
D | HOH793 |
site_id | BC3 |
Number of Residues | 15 |
Details | BINDING SITE FOR RESIDUE UMQ A 721 |
Chain | Residue |
A | TRP427 |
A | ASP428 |
A | SER453 |
A | MET454 |
A | MET455 |
A | ARG456 |
A | 3PH713 |
A | HOH752 |
E | TYR57 |
E | SER68 |
I | ASN14 |
I | ALA15 |
I | VAL16 |
I | PHE17 |
I | VAL18 |
site_id | BC4 |
Number of Residues | 12 |
Details | BINDING SITE FOR RESIDUE CDL D 731 |
Chain | Residue |
C | ASN27 |
C | TYR28 |
C | MET32 |
C | MET95 |
C | LEU235 |
D | TYR281 |
D | LYS288 |
D | LYS289 |
D | HOH746 |
D | HOH759 |
D | HOH768 |
G | HIS85 |
Functional Information from PROSITE/UniProt
site_id | PS00143 |
Number of Residues | 23 |
Details | INSULINASE Insulinase family, zinc-binding region signature. Ggsryatkd.GvAHLLNRFnFqNT |
Chain | Residue | Details |
B | GLY37-THR59 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 25 |
Details | TRANSMEM: Helical => ECO:0000269|PubMed:18390544, ECO:0000269|PubMed:30598554 |
Chain | Residue | Details |
I | GLY19-ASN44 | |
C | TYR103-ARG110 | |
C | GLY205-SER223 | |
C | ASP309-LYS319 | |
C | ILE365-LYS385 |
site_id | SWS_FT_FI2 |
Number of Residues | 30 |
Details | TRANSMEM: Helical => ECO:0000269|PubMed:18390544, ECO:0000269|PubMed:30598554 |
Chain | Residue | Details |
H | ARG50-LEU80 | |
C | GLY75-TYR102 | |
C | VAL111-VAL135 | |
C | ASN173-HIS204 | |
C | TYR224-TYR246 | |
C | LYS288-THR308 | |
C | VAL320-GLY340 | |
C | TYR348-LEU364 |
site_id | SWS_FT_FI3 |
Number of Residues | 13 |
Details | TOPO_DOM: Mitochondrial intermembrane => ECO:0000269|PubMed:18390544, ECO:0000269|PubMed:30598554 |
Chain | Residue | Details |
H | TYR81-VAL94 | |
D | CYS104 | |
C | SER247-ASP287 | |
C | ALA341-PRO347 |
site_id | SWS_FT_FI4 |
Number of Residues | 4 |
Details | BINDING: BINDING => ECO:0000269|PubMed:10873857, ECO:0000269|PubMed:11880631, ECO:0000269|PubMed:18390544, ECO:0000269|PubMed:30598554, ECO:0007744|PDB:1EZV, ECO:0007744|PDB:1KB9, ECO:0007744|PDB:1KYO, ECO:0007744|PDB:1P84, ECO:0007744|PDB:2IBZ, ECO:0007744|PDB:3CX5, ECO:0007744|PDB:3CXH, ECO:0007744|PDB:4PD4 |
Chain | Residue | Details |
E | CYS159 | |
E | HIS161 | |
E | CYS178 | |
E | HIS181 |
site_id | SWS_FT_FI5 |
Number of Residues | 1 |
Details | BINDING: axial binding residue => ECO:0000269|PubMed:10873857, ECO:0000269|PubMed:11880631, ECO:0000269|PubMed:18390544, ECO:0000269|PubMed:30598554, ECO:0007744|PDB:1EZV, ECO:0007744|PDB:1KYO |
Chain | Residue | Details |
D | MET225 | |
C | HIS96 | |
C | HIS183 | |
C | HIS197 |
site_id | SWS_FT_FI6 |
Number of Residues | 1 |
Details | BINDING: BINDING => ECO:0000250|UniProtKB:P00157 |
Chain | Residue | Details |
C | HIS202 |
Catalytic Information from CSA
site_id | CSA1 |
Number of Residues | 1 |
Details | Annotated By Reference To The Literature 1ndo |
Chain | Residue | Details |
E | HIS181 |
site_id | CSA2 |
Number of Residues | 1 |
Details | Annotated By Reference To The Literature 1ndo |
Chain | Residue | Details |
A | LYS74 |
site_id | CSA3 |
Number of Residues | 1 |
Details | Annotated By Reference To The Literature 1ndo |
Chain | Residue | Details |
B | ASN52 |
site_id | MCSA1 |
Number of Residues | 1 |
Details | M-CSA 208 |
Chain | Residue | Details |
E | HIS181 | covalently attached, hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, radical stabiliser |
C | SER206 | electrostatic stabiliser, hydrogen bond donor, radical stabiliser |
C | LYS228 | electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, radical stabiliser |
C | ASP229 | electrostatic stabiliser, hydrogen bond acceptor, radical stabiliser |
C | GLU272 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, radical stabiliser |