1P3H

Crystal Structure of the Mycobacterium tuberculosis chaperonin 10 tetradecamer

Replaces:  1JH2

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005576	cellular_component	extracellular region
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0006355	biological_process	regulation of DNA-templated transcription
A	0006457	biological_process	protein folding
A	0009274	cellular_component	peptidoglycan-based cell wall
A	0009408	biological_process	response to heat
A	0034605	biological_process	cellular response to heat
A	0035375	molecular_function	zymogen binding
A	0044183	molecular_function	protein folding chaperone
A	0046677	biological_process	response to antibiotic
A	0046872	molecular_function	metal ion binding
A	0051082	molecular_function	unfolded protein binding
A	0051085	biological_process	chaperone cofactor-dependent protein refolding
A	0051087	molecular_function	protein-folding chaperone binding
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005576	cellular_component	extracellular region
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0005886	cellular_component	plasma membrane
B	0006355	biological_process	regulation of DNA-templated transcription
B	0006457	biological_process	protein folding
B	0009274	cellular_component	peptidoglycan-based cell wall
B	0009408	biological_process	response to heat
B	0034605	biological_process	cellular response to heat
B	0035375	molecular_function	zymogen binding
B	0044183	molecular_function	protein folding chaperone
B	0046677	biological_process	response to antibiotic
B	0046872	molecular_function	metal ion binding
B	0051082	molecular_function	unfolded protein binding
B	0051085	biological_process	chaperone cofactor-dependent protein refolding
B	0051087	molecular_function	protein-folding chaperone binding
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005576	cellular_component	extracellular region
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0005886	cellular_component	plasma membrane
C	0006355	biological_process	regulation of DNA-templated transcription
C	0006457	biological_process	protein folding
C	0009274	cellular_component	peptidoglycan-based cell wall
C	0009408	biological_process	response to heat
C	0034605	biological_process	cellular response to heat
C	0035375	molecular_function	zymogen binding
C	0044183	molecular_function	protein folding chaperone
C	0046677	biological_process	response to antibiotic
C	0046872	molecular_function	metal ion binding
C	0051082	molecular_function	unfolded protein binding
C	0051085	biological_process	chaperone cofactor-dependent protein refolding
C	0051087	molecular_function	protein-folding chaperone binding
D	0005515	molecular_function	protein binding
D	0005524	molecular_function	ATP binding
D	0005576	cellular_component	extracellular region
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0005886	cellular_component	plasma membrane
D	0006355	biological_process	regulation of DNA-templated transcription
D	0006457	biological_process	protein folding
D	0009274	cellular_component	peptidoglycan-based cell wall
D	0009408	biological_process	response to heat
D	0034605	biological_process	cellular response to heat
D	0035375	molecular_function	zymogen binding
D	0044183	molecular_function	protein folding chaperone
D	0046677	biological_process	response to antibiotic
D	0046872	molecular_function	metal ion binding
D	0051082	molecular_function	unfolded protein binding
D	0051085	biological_process	chaperone cofactor-dependent protein refolding
D	0051087	molecular_function	protein-folding chaperone binding
E	0005515	molecular_function	protein binding
E	0005524	molecular_function	ATP binding
E	0005576	cellular_component	extracellular region
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0005886	cellular_component	plasma membrane
E	0006355	biological_process	regulation of DNA-templated transcription
E	0006457	biological_process	protein folding
E	0009274	cellular_component	peptidoglycan-based cell wall
E	0009408	biological_process	response to heat
E	0034605	biological_process	cellular response to heat
E	0035375	molecular_function	zymogen binding
E	0044183	molecular_function	protein folding chaperone
E	0046677	biological_process	response to antibiotic
E	0046872	molecular_function	metal ion binding
E	0051082	molecular_function	unfolded protein binding
E	0051085	biological_process	chaperone cofactor-dependent protein refolding
E	0051087	molecular_function	protein-folding chaperone binding
F	0005515	molecular_function	protein binding
F	0005524	molecular_function	ATP binding
F	0005576	cellular_component	extracellular region
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0005886	cellular_component	plasma membrane
F	0006355	biological_process	regulation of DNA-templated transcription
F	0006457	biological_process	protein folding
F	0009274	cellular_component	peptidoglycan-based cell wall
F	0009408	biological_process	response to heat
F	0034605	biological_process	cellular response to heat
F	0035375	molecular_function	zymogen binding
F	0044183	molecular_function	protein folding chaperone
F	0046677	biological_process	response to antibiotic
F	0046872	molecular_function	metal ion binding
F	0051082	molecular_function	unfolded protein binding
F	0051085	biological_process	chaperone cofactor-dependent protein refolding
F	0051087	molecular_function	protein-folding chaperone binding
G	0005515	molecular_function	protein binding
G	0005524	molecular_function	ATP binding
G	0005576	cellular_component	extracellular region
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0005886	cellular_component	plasma membrane
G	0006355	biological_process	regulation of DNA-templated transcription
G	0006457	biological_process	protein folding
G	0009274	cellular_component	peptidoglycan-based cell wall
G	0009408	biological_process	response to heat
G	0034605	biological_process	cellular response to heat
G	0035375	molecular_function	zymogen binding
G	0044183	molecular_function	protein folding chaperone
G	0046677	biological_process	response to antibiotic
G	0046872	molecular_function	metal ion binding
G	0051082	molecular_function	unfolded protein binding
G	0051085	biological_process	chaperone cofactor-dependent protein refolding
G	0051087	molecular_function	protein-folding chaperone binding
H	0005515	molecular_function	protein binding
H	0005524	molecular_function	ATP binding
H	0005576	cellular_component	extracellular region
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0005886	cellular_component	plasma membrane
H	0006355	biological_process	regulation of DNA-templated transcription
H	0006457	biological_process	protein folding
H	0009274	cellular_component	peptidoglycan-based cell wall
H	0009408	biological_process	response to heat
H	0034605	biological_process	cellular response to heat
H	0035375	molecular_function	zymogen binding
H	0044183	molecular_function	protein folding chaperone
H	0046677	biological_process	response to antibiotic
H	0046872	molecular_function	metal ion binding
H	0051082	molecular_function	unfolded protein binding
H	0051085	biological_process	chaperone cofactor-dependent protein refolding
H	0051087	molecular_function	protein-folding chaperone binding
I	0005515	molecular_function	protein binding
I	0005524	molecular_function	ATP binding
I	0005576	cellular_component	extracellular region
I	0005737	cellular_component	cytoplasm
I	0005829	cellular_component	cytosol
I	0005886	cellular_component	plasma membrane
I	0006355	biological_process	regulation of DNA-templated transcription
I	0006457	biological_process	protein folding
I	0009274	cellular_component	peptidoglycan-based cell wall
I	0009408	biological_process	response to heat
I	0034605	biological_process	cellular response to heat
I	0035375	molecular_function	zymogen binding
I	0044183	molecular_function	protein folding chaperone
I	0046677	biological_process	response to antibiotic
I	0046872	molecular_function	metal ion binding
I	0051082	molecular_function	unfolded protein binding
I	0051085	biological_process	chaperone cofactor-dependent protein refolding
I	0051087	molecular_function	protein-folding chaperone binding
J	0005515	molecular_function	protein binding
J	0005524	molecular_function	ATP binding
J	0005576	cellular_component	extracellular region
J	0005737	cellular_component	cytoplasm
J	0005829	cellular_component	cytosol
J	0005886	cellular_component	plasma membrane
J	0006355	biological_process	regulation of DNA-templated transcription
J	0006457	biological_process	protein folding
J	0009274	cellular_component	peptidoglycan-based cell wall
J	0009408	biological_process	response to heat
J	0034605	biological_process	cellular response to heat
J	0035375	molecular_function	zymogen binding
J	0044183	molecular_function	protein folding chaperone
J	0046677	biological_process	response to antibiotic
J	0046872	molecular_function	metal ion binding
J	0051082	molecular_function	unfolded protein binding
J	0051085	biological_process	chaperone cofactor-dependent protein refolding
J	0051087	molecular_function	protein-folding chaperone binding
K	0005515	molecular_function	protein binding
K	0005524	molecular_function	ATP binding
K	0005576	cellular_component	extracellular region
K	0005737	cellular_component	cytoplasm
K	0005829	cellular_component	cytosol
K	0005886	cellular_component	plasma membrane
K	0006355	biological_process	regulation of DNA-templated transcription
K	0006457	biological_process	protein folding
K	0009274	cellular_component	peptidoglycan-based cell wall
K	0009408	biological_process	response to heat
K	0034605	biological_process	cellular response to heat
K	0035375	molecular_function	zymogen binding
K	0044183	molecular_function	protein folding chaperone
K	0046677	biological_process	response to antibiotic
K	0046872	molecular_function	metal ion binding
K	0051082	molecular_function	unfolded protein binding
K	0051085	biological_process	chaperone cofactor-dependent protein refolding
K	0051087	molecular_function	protein-folding chaperone binding
L	0005515	molecular_function	protein binding
L	0005524	molecular_function	ATP binding
L	0005576	cellular_component	extracellular region
L	0005737	cellular_component	cytoplasm
L	0005829	cellular_component	cytosol
L	0005886	cellular_component	plasma membrane
L	0006355	biological_process	regulation of DNA-templated transcription
L	0006457	biological_process	protein folding
L	0009274	cellular_component	peptidoglycan-based cell wall
L	0009408	biological_process	response to heat
L	0034605	biological_process	cellular response to heat
L	0035375	molecular_function	zymogen binding
L	0044183	molecular_function	protein folding chaperone
L	0046677	biological_process	response to antibiotic
L	0046872	molecular_function	metal ion binding
L	0051082	molecular_function	unfolded protein binding
L	0051085	biological_process	chaperone cofactor-dependent protein refolding
L	0051087	molecular_function	protein-folding chaperone binding
M	0005515	molecular_function	protein binding
M	0005524	molecular_function	ATP binding
M	0005576	cellular_component	extracellular region
M	0005737	cellular_component	cytoplasm
M	0005829	cellular_component	cytosol
M	0005886	cellular_component	plasma membrane
M	0006355	biological_process	regulation of DNA-templated transcription
M	0006457	biological_process	protein folding
M	0009274	cellular_component	peptidoglycan-based cell wall
M	0009408	biological_process	response to heat
M	0034605	biological_process	cellular response to heat
M	0035375	molecular_function	zymogen binding
M	0044183	molecular_function	protein folding chaperone
M	0046677	biological_process	response to antibiotic
M	0046872	molecular_function	metal ion binding
M	0051082	molecular_function	unfolded protein binding
M	0051085	biological_process	chaperone cofactor-dependent protein refolding
M	0051087	molecular_function	protein-folding chaperone binding
N	0005515	molecular_function	protein binding
N	0005524	molecular_function	ATP binding
N	0005576	cellular_component	extracellular region
N	0005737	cellular_component	cytoplasm
N	0005829	cellular_component	cytosol
N	0005886	cellular_component	plasma membrane
N	0006355	biological_process	regulation of DNA-templated transcription
N	0006457	biological_process	protein folding
N	0009274	cellular_component	peptidoglycan-based cell wall
N	0009408	biological_process	response to heat
N	0034605	biological_process	cellular response to heat
N	0035375	molecular_function	zymogen binding
N	0044183	molecular_function	protein folding chaperone
N	0046677	biological_process	response to antibiotic
N	0046872	molecular_function	metal ion binding
N	0051082	molecular_function	unfolded protein binding
N	0051085	biological_process	chaperone cofactor-dependent protein refolding
N	0051087	molecular_function	protein-folding chaperone binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CA A 200

Chain	Residue
A	ASP53
A	HOH203
B	ASP51
B	GLU55

---

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MPD A 101

Chain	Residue
A	TYR85
A	VAL3
A	ASN4
A	ILE5
A	LEU13
A	TYR80

---

site_id	AC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE MPD B 102

Chain	Residue
B	LYS2
B	VAL3
B	ASN4
B	ILE5
B	LEU13
B	VAL43
B	TYR85

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MPD C 103

Chain	Residue
C	VAL3
C	ILE5
C	TYR80
C	TYR85

---

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MPD D 104

Chain	Residue
D	VAL3
D	ASN4
D	LEU13
D	TYR85

---

site_id	AC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE MPD E 105

Chain	Residue
E	ILE5
E	TYR85

---

site_id	AC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MPD F 106

Chain	Residue
F	VAL3
F	ILE5
F	LEU13
F	VAL43
F	TYR80

---

site_id	AC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MPD G 107

Chain	Residue
G	VAL3
G	ASN4
G	ILE5
G	VAL43

---

site_id	AC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MPD H 108

Chain	Residue
H	VAL3
H	ILE5
H	LEU13

---

site_id	BC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE MPD I 109

Chain	Residue
I	ASN4
I	ILE5
I	VAL43
I	TYR85
L	ASN81
L	GLY82
L	GLU83

---

site_id	BC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE MPD J 110

Chain	Residue
J	VAL3
J	TYR85

---

site_id	BC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MPD K 111

Chain	Residue
K	VAL3
K	ASN4
K	ILE5
K	TYR80

---

site_id	BC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MPD L 112

Chain	Residue
L	VAL3
L	ASN4
L	ILE5
L	LEU13
L	TYR85

---

site_id	BC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MPD M 113

Chain	Residue
M	VAL3
M	ASN4
M	ILE5
M	LEU13
M	TYR80
M	TYR85

---

site_id	BC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MPD N 114

Chain	Residue
N	ASN4
N	ILE5
N	LEU13
N	VAL43
N	ALA44
N	TYR85

---

site_id	BC7
Number of Residues	2
Details	BINDING SITE FOR RESIDUE MPD A 115

Chain	Residue
A	ASN4
A	GLU64

---

site_id	BC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE MPD H 116

Chain	Residue
H	GLN15
H	GLU83

---

site_id	BC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MPD H 117

Chain	Residue
H	VAL45
H	GLU64
H	MPD118

---

site_id	CC1
Number of Residues	1
Details	BINDING SITE FOR RESIDUE MPD H 118

Chain	Residue
H	MPD117

---

Functional Information from PROSITE/UniProt

site_id	PS00681
Number of Residues	25
Details	CHAPERONINS_CPN10 Chaperonins cpn10 signature. IkPLeDKILVQaneaetttaSgLVI

Chain	Residue	Details
A	ILE5-ILE29

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	14
Details	MOD_RES: N-acetylalanine => ECO:0000269|PubMed:27353550, ECO:0007744|PubMed:21969609

Chain	Residue	Details
A	LYS2
J	LYS2
K	LYS2
L	LYS2
M	LYS2
N	LYS2
B	LYS2
C	LYS2
D	LYS2
E	LYS2
F	LYS2
G	LYS2
H	LYS2
I	LYS2

---

site_id	SWS_FT_FI2
Number of Residues	28
Details	CROSSLNK: Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-Cter in protein Pup) => ECO:0000269|PubMed:20066036

Chain	Residue	Details
A	LYS99
F	LYS99
G	LYS99
H	LYS99
I	LYS99
J	LYS99
K	LYS99
L	LYS99
M	LYS99
N	LYS99
B	LYS99
C	LYS99
D	LYS99
E	LYS99

---