1P39

DC26 MUTANT OF VACCINIA VIRUS PROTEIN VP39 IN COMPLEX WITH S-ADENOSYLHOMOCYSTEINE AND M7G(5')PPPG

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003723	molecular_function	RNA binding
A	0003746	molecular_function	translation elongation factor activity
A	0004483	molecular_function	mRNA (nucleoside-2'-O-)-methyltransferase activity
A	0006370	biological_process	7-methylguanosine mRNA capping
A	0006397	biological_process	mRNA processing
A	0006412	biological_process	translation
A	0006414	biological_process	translational elongation
A	0008168	molecular_function	methyltransferase activity
A	0016740	molecular_function	transferase activity
A	0031440	biological_process	regulation of mRNA 3'-end processing
A	0032259	biological_process	methylation
A	0044423	cellular_component	virion component
A	0080009	biological_process	obsolete mRNA methylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	17
Details	BINDING SITE FOR RESIDUE SAH A 400

Chain	Residue
A	GLN39
A	ILE94
A	ASP95
A	ARG97
A	PHE115
A	VAL116
A	ASP138
A	VAL139
A	ARG140
A	LEU42
A	TYR66
A	GLY68
A	SER69
A	ALA70
A	PRO71
A	GLY72
A	HIS74

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site_id	AC2
Number of Residues	13
Details	BINDING SITE FOR RESIDUE MGT A 401

Chain	Residue
A	TYR22
A	ARG177
A	PHE180
A	ASP182
A	PRO202
A	TYR204
A	SER205
A	GLU207
A	GLU233
A	HOH592
A	HOH603
A	HOH624
A	HOH901

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: For methyltransferase activity => ECO:0000305|PubMed:15134442

Chain	Residue	Details
A	LYS175

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site_id	SWS_FT_FI2
Number of Residues	5
Details	BINDING:

Chain	Residue	Details
A	TYR22
A	ARG177
A	ASP182
A	SER205
A	GLU233

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site_id	SWS_FT_FI3
Number of Residues	8
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00944, ECO:0000269|PubMed:8612277

Chain	Residue	Details
A	GLN39
A	TYR66
A	GLY68
A	GLY72
A	ASP95
A	ARG97
A	VAL116
A	ASP138

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