Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004252 | molecular_function | serine-type endopeptidase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005576 | cellular_component | extracellular region |
| A | 0006508 | biological_process | proteolysis |
| A | 0007586 | biological_process | digestion |
| A | 0008236 | molecular_function | serine-type peptidase activity |
| A | 0097180 | cellular_component | serine protease inhibitor complex |
| A | 0097655 | molecular_function | serpin family protein binding |
| B | 0004867 | molecular_function | serine-type endopeptidase inhibitor activity |
| C | 0004252 | molecular_function | serine-type endopeptidase activity |
| C | 0005515 | molecular_function | protein binding |
| C | 0005576 | cellular_component | extracellular region |
| C | 0006508 | biological_process | proteolysis |
| C | 0007586 | biological_process | digestion |
| C | 0008236 | molecular_function | serine-type peptidase activity |
| C | 0097180 | cellular_component | serine protease inhibitor complex |
| C | 0097655 | molecular_function | serpin family protein binding |
| D | 0004867 | molecular_function | serine-type endopeptidase inhibitor activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 B 601 |
| Chain | Residue |
| B | PHE4 |
| B | GLU7 |
| B | ARG42 |
| B | HOH2016 |
| B | HOH2307 |
| D | TYR10 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 B 602 |
| Chain | Residue |
| B | GLY37 |
| C | LEU97 |
| A | HOH660 |
| B | ARG20 |
| B | TYR35 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 B 603 |
| Chain | Residue |
| B | TYR10 |
| B | HOH2303 |
| D | PHE4 |
| D | GLU7 |
| D | ARG42 |
| D | HOH2017 |
| site_id | AC4 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE SO4 B 604 |
| Chain | Residue |
| B | PRO2 |
| B | ASP3 |
| B | HOH2015 |
| B | HOH2028 |
| B | HOH2209 |
| B | HOH2277 |
| B | HOH2364 |
| C | TYR171 |
| C | TRP172 |
| C | SER217 |
| C | SER218 |
| C | HOH2082 |
| site_id | AC5 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE SO4 A 605 |
| Chain | Residue |
| A | TYR171 |
| A | TRP172 |
| A | SER217 |
| A | SER218 |
| A | HOH2040 |
| A | HOH2240 |
| A | HOH2298 |
| D | PRO2 |
| D | ASP3 |
| D | HOH2007 |
| D | HOH2014 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 D 1602 |
| Chain | Residue |
| C | HOH1660 |
| D | ARG20 |
| D | TYR35 |
| D | GLY37 |
Functional Information from PROSITE/UniProt
| site_id | PS00280 |
| Number of Residues | 19 |
| Details | BPTI_KUNITZ_1 Pancreatic trypsin inhibitor (Kunitz) family signature. FvyGGCrakrnnFksaedC |
| Chain | Residue | Details |
| B | PHE33-CYS51 | |
| site_id | PS00134 |
| Number of Residues | 6 |
| Details | TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. VTAAHC |
| Chain | Residue | Details |
| A | VAL53-CYS58 | |
| site_id | PS00135 |
| Number of Residues | 12 |
| Details | TRYPSIN_SER Serine proteases, trypsin family, serine active site. SScmGDSGGPLV |
| Chain | Residue | Details |
| A | SER189-VAL200 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | SITE: Reactive bond for trypsin |
| Chain | Residue | Details |
| B | GLY15 | |
| D | GLY15 | |
| A | SER195 | |
| C | HIS57 | |
| C | ASP102 | |
| C | SER195 | |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| A | ASP102 | |
| A | SER195 | |
| A | HIS57 | |
| site_id | CSA2 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| C | ASP102 | |
| C | SER195 | |
| C | HIS57 | |
| site_id | CSA3 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| A | ASP102 | |
| A | SER195 | |
| A | GLY193 | |
| A | HIS57 | |
| site_id | CSA4 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| C | ASP102 | |
| C | SER195 | |
| C | GLY193 | |
| C | HIS57 | |
| site_id | CSA5 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| A | ASP102 | |
| A | SER195 | |
| A | HIS57 | |
| A | GLY196 | |
| site_id | CSA6 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| C | ASP102 | |
| C | SER195 | |
| C | HIS57 | |
| C | GLY196 | |
| site_id | MCSA1 |
| Number of Residues | 5 |
| Details | M-CSA 387 |
| Chain | Residue | Details |
| A | HIS57 | electrostatic stabiliser, proton shuttle (general acid/base) |
| A | ASP102 | modifies pKa |
| A | GLY193 | electrostatic stabiliser |
| A | SER195 | covalent catalysis |
| A | GLY196 | electrostatic stabiliser |
| site_id | MCSA2 |
| Number of Residues | 5 |
| Details | M-CSA 387 |
| Chain | Residue | Details |
| C | HIS57 | electrostatic stabiliser, proton shuttle (general acid/base) |
| C | ASP102 | modifies pKa |
| C | GLY193 | electrostatic stabiliser |
| C | SER195 | covalent catalysis |
| C | GLY196 | electrostatic stabiliser |
