1P11

CRYSTAL STRUCTURES OF ALPHA-LYTIC PROTEASE COMPLEXES WITH IRREVERSIBLY BOUND PHOSPHONATE ESTERS

Functional Information from GO Data

Chain	GOid	namespace	contents
E	0004252	molecular_function	serine-type endopeptidase activity
E	0006508	biological_process	proteolysis

Functional Information from PDB Data

site_id	AC1
Number of Residues	9
Details	BINDING SITE FOR RESIDUE SO4 E 1

Chain	Residue
E	ALA15
E	ASN15
E	ARG230
E	PRO233
E	HOH266
E	HOH277
E	HOH292
E	HOH367
E	HOH381

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site_id	AC2
Number of Residues	30
Details	BINDING SITE FOR CHAIN P OF PHOSPHONATE ESTER INHIBITOR A

Chain	Residue
E	SER40
E	LEU41
E	HIS57
E	ARG125
E	THR128
E	TYR171
E	GLY192
E	ARG192
E	GLY193
E	ASP194
E	SER195
E	GLN208
E	SER214
E	GLY215
E	GLY216
E	VAL217
E	GLY244
E	HOH247
E	HOH348
I	PVA1
I	PRO2
I	ALA3
I	ALA4
I	BOC5
P	HOH6
P	HOH7
P	HOH8
P	HOH9
P	HOH10
P	HOH11

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site_id	AC3
Number of Residues	23
Details	BINDING SITE FOR CHAIN I OF PHOSPHONATE ESTER INHIBITOR B(TRANSITION STATE)

Chain	Residue
E	HIS57
E	ARG125
E	TYR171
E	GLY192
E	GLY193
E	ASP194
E	SER195
E	SER214
E	GLY215
E	GLY216
E	VAL217
E	GLY244
E	HOH348
P	LAC-1
P	ALA-2
P	PVA1
P	PRO2
P	ALA3
P	ALA4
P	BOC5
P	HOH6
P	HOH8
P	HOH10

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Functional Information from PROSITE/UniProt

site_id	PS00134
Number of Residues	6
Details	TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. VTAGHC

Chain	Residue	Details
E	VAL53-CYS58

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site_id	PS00135
Number of Residues	12
Details	TRYPSIN_SER Serine proteases, trypsin family, serine active site. CMgrGDSGGSWI

Chain	Residue	Details
E	CYS191-ILE200

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	Active site: {"description":"Charge relay system","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	5
Details	Annotated By Reference To The Literature 1ssx

Chain	Residue	Details
E	ASP102
E	SER195
E	GLY193
E	HIS57
E	SER214

---

site_id	CSA2
Number of Residues	4
Details	Annotated By Reference To The Literature 1ssx

Chain	Residue	Details
E	ASP102
E	SER195
E	GLY193
E	HIS57

---

site_id	MCSA1
Number of Residues	5
Details	M-CSA 609

Chain

Residue

Details

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