Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004745 | molecular_function | all-trans-retinol dehydrogenase (NAD+) activity |
| A | 0005829 | cellular_component | cytosol |
| A | 0008106 | molecular_function | alcohol dehydrogenase (NADP+) activity |
| A | 0008270 | molecular_function | zinc ion binding |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0042572 | biological_process | retinol metabolic process |
| A | 0042573 | biological_process | retinoic acid metabolic process |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0004745 | molecular_function | all-trans-retinol dehydrogenase (NAD+) activity |
| B | 0005829 | cellular_component | cytosol |
| B | 0008106 | molecular_function | alcohol dehydrogenase (NADP+) activity |
| B | 0008270 | molecular_function | zinc ion binding |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0042572 | biological_process | retinol metabolic process |
| B | 0042573 | biological_process | retinoic acid metabolic process |
| B | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ZN A 1502 |
| Chain | Residue |
| A | CYS1046 |
| A | HIS1067 |
| A | CYS1173 |
| A | NAP4292 |
| A | GOL8001 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ZN B 1503 |
| Chain | Residue |
| B | GOL8002 |
| B | CYS2046 |
| B | HIS2067 |
| B | CYS2173 |
| B | NAP3292 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN B 2501 |
| Chain | Residue |
| B | CYS2097 |
| B | CYS2100 |
| B | CYS2103 |
| B | CYS2111 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 2502 |
| Chain | Residue |
| A | CYS1097 |
| A | CYS1100 |
| A | CYS1103 |
| A | CYS1111 |
| site_id | AC5 |
| Number of Residues | 31 |
| Details | BINDING SITE FOR RESIDUE NAP B 3292 |
| Chain | Residue |
| B | HOH68 |
| B | HOH70 |
| B | HOH80 |
| B | HOH83 |
| B | HOH84 |
| B | HOH85 |
| B | HOH309 |
| B | ZN1503 |
| B | CYS2046 |
| B | GLY2047 |
| B | SER2048 |
| B | CYS2173 |
| B | THR2177 |
| B | GLY2198 |
| B | LEU2199 |
| B | GLY2200 |
| B | GLY2201 |
| B | VAL2202 |
| B | GLY2222 |
| B | THR2223 |
| B | HIS2224 |
| B | LYS2227 |
| B | CYS2267 |
| B | ALA2268 |
| B | ARG2270 |
| B | LEU2291 |
| B | SER2316 |
| B | VAL2317 |
| B | PHE2318 |
| B | ARG2367 |
| B | GOL8002 |
| site_id | AC6 |
| Number of Residues | 34 |
| Details | BINDING SITE FOR RESIDUE NAP A 4292 |
| Chain | Residue |
| A | HOH107 |
| A | HOH110 |
| A | HOH186 |
| A | HOH187 |
| A | HOH209 |
| A | HOH261 |
| A | HOH307 |
| A | CYS1046 |
| A | GLY1047 |
| A | SER1048 |
| A | CYS1173 |
| A | THR1177 |
| A | GLY1198 |
| A | LEU1199 |
| A | GLY1200 |
| A | GLY1201 |
| A | VAL1202 |
| A | GLY1222 |
| A | THR1223 |
| A | HIS1224 |
| A | LYS1227 |
| A | CYS1267 |
| A | ALA1268 |
| A | GLY1269 |
| A | ARG1270 |
| A | LEU1291 |
| A | GLY1292 |
| A | LEU1293 |
| A | SER1316 |
| A | VAL1317 |
| A | PHE1318 |
| A | ARG1367 |
| A | ZN1502 |
| A | GOL8001 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL A 8001 |
| Chain | Residue |
| A | SER1048 |
| A | HIS1067 |
| A | MET1116 |
| A | MET1141 |
| A | ZN1502 |
| A | NAP4292 |
| site_id | AC8 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL B 8002 |
| Chain | Residue |
| B | ZN1503 |
| B | SER2048 |
| B | HIS2067 |
| B | MET2116 |
| B | MET2141 |
| B | LEU2293 |
| B | NAP3292 |
Functional Information from PROSITE/UniProt
| site_id | PS00059 |
| Number of Residues | 15 |
| Details | ADH_ZINC Zinc-containing alcohol dehydrogenases signature. GHEaVGVvesiGagV |
| Chain | Residue | Details |
| A | GLY1066-VAL1080 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 14 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N-acetylcysteine","evidences":[{"evidenceCode":"ECO:0000250"}]} |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1guf |
| Chain | Residue | Details |
| A | SER1051 | |
| A | SER1048 | |
| site_id | CSA2 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1guf |
| Chain | Residue | Details |
| B | SER2051 | |
| B | SER2048 | |
| site_id | CSA3 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1guf |
| Chain | Residue | Details |
| A | ILE1057 | |
| site_id | CSA4 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1guf |
| Chain | Residue | Details |
| B | ILE2057 | |
