1OZT

Crystal Structure of apo-H46R Familial ALS Mutant human Cu,Zn Superoxide Dismutase (CuZnSOD) to 2.5A resolution

Functional Information from GO Data

Chain	GOid	namespace	contents
G	0000302	biological_process	response to reactive oxygen species
G	0000303	biological_process	response to superoxide
G	0001541	biological_process	ovarian follicle development
G	0001819	biological_process	positive regulation of cytokine production
G	0001890	biological_process	placenta development
G	0001895	biological_process	retina homeostasis
G	0001975	biological_process	response to amphetamine
G	0002262	biological_process	myeloid cell homeostasis
G	0004784	molecular_function	superoxide dismutase activity
G	0005507	molecular_function	copper ion binding
G	0005515	molecular_function	protein binding
G	0005576	cellular_component	extracellular region
G	0005615	cellular_component	extracellular space
G	0005634	cellular_component	nucleus
G	0005654	cellular_component	nucleoplasm
G	0005737	cellular_component	cytoplasm
G	0005739	cellular_component	mitochondrion
G	0005758	cellular_component	mitochondrial intermembrane space
G	0005759	cellular_component	mitochondrial matrix
G	0005764	cellular_component	lysosome
G	0005777	cellular_component	peroxisome
G	0005829	cellular_component	cytosol
G	0005886	cellular_component	plasma membrane
G	0006749	biological_process	glutathione metabolic process
G	0006801	biological_process	superoxide metabolic process
G	0006879	biological_process	intracellular iron ion homeostasis
G	0006915	biological_process	apoptotic process
G	0006979	biological_process	response to oxidative stress
G	0007283	biological_process	spermatogenesis
G	0007566	biological_process	embryo implantation
G	0007605	biological_process	sensory perception of sound
G	0007626	biological_process	locomotory behavior
G	0008089	biological_process	anterograde axonal transport
G	0008090	biological_process	retrograde axonal transport
G	0008217	biological_process	regulation of blood pressure
G	0008270	molecular_function	zinc ion binding
G	0008340	biological_process	determination of adult lifespan
G	0009408	biological_process	response to heat
G	0009410	biological_process	response to xenobiotic stimulus
G	0010467	biological_process	gene expression
G	0016209	molecular_function	antioxidant activity
G	0016491	molecular_function	oxidoreductase activity
G	0019226	biological_process	transmission of nerve impulse
G	0019228	biological_process	neuronal action potential
G	0019430	biological_process	removal of superoxide radicals
G	0019899	molecular_function	enzyme binding
G	0030141	cellular_component	secretory granule
G	0030346	molecular_function	protein phosphatase 2B binding
G	0031045	cellular_component	dense core granule
G	0031267	molecular_function	small GTPase binding
G	0031410	cellular_component	cytoplasmic vesicle
G	0031667	biological_process	response to nutrient levels
G	0032287	biological_process	peripheral nervous system myelin maintenance
G	0032839	cellular_component	dendrite cytoplasm
G	0032930	biological_process	positive regulation of superoxide anion generation
G	0032991	cellular_component	protein-containing complex
G	0033081	biological_process	regulation of T cell differentiation in thymus
G	0034465	biological_process	response to carbon monoxide
G	0034599	biological_process	cellular response to oxidative stress
G	0035234	biological_process	ectopic germ cell programmed cell death
G	0035865	biological_process	cellular response to potassium ion
G	0040014	biological_process	regulation of multicellular organism growth
G	0042542	biological_process	response to hydrogen peroxide
G	0042554	biological_process	superoxide anion generation
G	0042802	molecular_function	identical protein binding
G	0042803	molecular_function	protein homodimerization activity
G	0043025	cellular_component	neuronal cell body
G	0043065	biological_process	positive regulation of apoptotic process
G	0043066	biological_process	negative regulation of apoptotic process
G	0043087	biological_process	regulation of GTPase activity
G	0043410	biological_process	positive regulation of MAPK cascade
G	0043524	biological_process	negative regulation of neuron apoptotic process
G	0045471	biological_process	response to ethanol
G	0046620	biological_process	regulation of organ growth
G	0046688	biological_process	response to copper ion
G	0046716	biological_process	muscle cell cellular homeostasis
G	0046872	molecular_function	metal ion binding
G	0048538	biological_process	thymus development
G	0048678	biological_process	response to axon injury
G	0050665	biological_process	hydrogen peroxide biosynthetic process
G	0050728	biological_process	negative regulation of inflammatory response
G	0050766	biological_process	positive regulation of phagocytosis
G	0051087	molecular_function	protein-folding chaperone binding
G	0051093	biological_process	negative regulation of developmental process
G	0051881	biological_process	regulation of mitochondrial membrane potential
G	0060047	biological_process	heart contraction
G	0060052	biological_process	neurofilament cytoskeleton organization
G	0060087	biological_process	relaxation of vascular associated smooth muscle
G	0060088	biological_process	auditory receptor cell stereocilium organization
G	0070062	cellular_component	extracellular exosome
G	0071276	biological_process	cellular response to cadmium ion
G	0071318	biological_process	cellular response to ATP
G	0072593	biological_process	reactive oxygen species metabolic process
G	0097332	biological_process	response to antipsychotic drug
G	0099610	biological_process	action potential initiation
G	1902177	biological_process	positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
G	1904115	cellular_component	axon cytoplasm
G	2000242	biological_process	negative regulation of reproductive process
H	0000302	biological_process	response to reactive oxygen species
H	0000303	biological_process	response to superoxide
H	0001541	biological_process	ovarian follicle development
H	0001819	biological_process	positive regulation of cytokine production
H	0001890	biological_process	placenta development
H	0001895	biological_process	retina homeostasis
H	0001975	biological_process	response to amphetamine
H	0002262	biological_process	myeloid cell homeostasis
H	0004784	molecular_function	superoxide dismutase activity
H	0005507	molecular_function	copper ion binding
H	0005515	molecular_function	protein binding
H	0005576	cellular_component	extracellular region
H	0005615	cellular_component	extracellular space
H	0005634	cellular_component	nucleus
H	0005654	cellular_component	nucleoplasm
H	0005737	cellular_component	cytoplasm
H	0005739	cellular_component	mitochondrion
H	0005758	cellular_component	mitochondrial intermembrane space
H	0005759	cellular_component	mitochondrial matrix
H	0005764	cellular_component	lysosome
H	0005777	cellular_component	peroxisome
H	0005829	cellular_component	cytosol
H	0005886	cellular_component	plasma membrane
H	0006749	biological_process	glutathione metabolic process
H	0006801	biological_process	superoxide metabolic process
H	0006879	biological_process	intracellular iron ion homeostasis
H	0006915	biological_process	apoptotic process
H	0006979	biological_process	response to oxidative stress
H	0007283	biological_process	spermatogenesis
H	0007566	biological_process	embryo implantation
H	0007605	biological_process	sensory perception of sound
H	0007626	biological_process	locomotory behavior
H	0008089	biological_process	anterograde axonal transport
H	0008090	biological_process	retrograde axonal transport
H	0008217	biological_process	regulation of blood pressure
H	0008270	molecular_function	zinc ion binding
H	0008340	biological_process	determination of adult lifespan
H	0009408	biological_process	response to heat
H	0009410	biological_process	response to xenobiotic stimulus
H	0010467	biological_process	gene expression
H	0016209	molecular_function	antioxidant activity
H	0016491	molecular_function	oxidoreductase activity
H	0019226	biological_process	transmission of nerve impulse
H	0019228	biological_process	neuronal action potential
H	0019430	biological_process	removal of superoxide radicals
H	0019899	molecular_function	enzyme binding
H	0030141	cellular_component	secretory granule
H	0030346	molecular_function	protein phosphatase 2B binding
H	0031045	cellular_component	dense core granule
H	0031267	molecular_function	small GTPase binding
H	0031410	cellular_component	cytoplasmic vesicle
H	0031667	biological_process	response to nutrient levels
H	0032287	biological_process	peripheral nervous system myelin maintenance
H	0032839	cellular_component	dendrite cytoplasm
H	0032930	biological_process	positive regulation of superoxide anion generation
H	0032991	cellular_component	protein-containing complex
H	0033081	biological_process	regulation of T cell differentiation in thymus
H	0034465	biological_process	response to carbon monoxide
H	0034599	biological_process	cellular response to oxidative stress
H	0035234	biological_process	ectopic germ cell programmed cell death
H	0035865	biological_process	cellular response to potassium ion
H	0040014	biological_process	regulation of multicellular organism growth
H	0042542	biological_process	response to hydrogen peroxide
H	0042554	biological_process	superoxide anion generation
H	0042802	molecular_function	identical protein binding
H	0042803	molecular_function	protein homodimerization activity
H	0043025	cellular_component	neuronal cell body
H	0043065	biological_process	positive regulation of apoptotic process
H	0043066	biological_process	negative regulation of apoptotic process
H	0043087	biological_process	regulation of GTPase activity
H	0043410	biological_process	positive regulation of MAPK cascade
H	0043524	biological_process	negative regulation of neuron apoptotic process
H	0045471	biological_process	response to ethanol
H	0046620	biological_process	regulation of organ growth
H	0046688	biological_process	response to copper ion
H	0046716	biological_process	muscle cell cellular homeostasis
H	0046872	molecular_function	metal ion binding
H	0048538	biological_process	thymus development
H	0048678	biological_process	response to axon injury
H	0050665	biological_process	hydrogen peroxide biosynthetic process
H	0050728	biological_process	negative regulation of inflammatory response
H	0050766	biological_process	positive regulation of phagocytosis
H	0051087	molecular_function	protein-folding chaperone binding
H	0051093	biological_process	negative regulation of developmental process
H	0051881	biological_process	regulation of mitochondrial membrane potential
H	0060047	biological_process	heart contraction
H	0060052	biological_process	neurofilament cytoskeleton organization
H	0060087	biological_process	relaxation of vascular associated smooth muscle
H	0060088	biological_process	auditory receptor cell stereocilium organization
H	0070062	cellular_component	extracellular exosome
H	0071276	biological_process	cellular response to cadmium ion
H	0071318	biological_process	cellular response to ATP
H	0072593	biological_process	reactive oxygen species metabolic process
H	0097332	biological_process	response to antipsychotic drug
H	0099610	biological_process	action potential initiation
H	1902177	biological_process	positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
H	1904115	cellular_component	axon cytoplasm
H	2000242	biological_process	negative regulation of reproductive process
I	0000302	biological_process	response to reactive oxygen species
I	0000303	biological_process	response to superoxide
I	0001541	biological_process	ovarian follicle development
I	0001819	biological_process	positive regulation of cytokine production
I	0001890	biological_process	placenta development
I	0001895	biological_process	retina homeostasis
I	0001975	biological_process	response to amphetamine
I	0002262	biological_process	myeloid cell homeostasis
I	0004784	molecular_function	superoxide dismutase activity
I	0005507	molecular_function	copper ion binding
I	0005515	molecular_function	protein binding
I	0005576	cellular_component	extracellular region
I	0005615	cellular_component	extracellular space
I	0005634	cellular_component	nucleus
I	0005654	cellular_component	nucleoplasm
I	0005737	cellular_component	cytoplasm
I	0005739	cellular_component	mitochondrion
I	0005758	cellular_component	mitochondrial intermembrane space
I	0005759	cellular_component	mitochondrial matrix
I	0005764	cellular_component	lysosome
I	0005777	cellular_component	peroxisome
I	0005829	cellular_component	cytosol
I	0005886	cellular_component	plasma membrane
I	0006749	biological_process	glutathione metabolic process
I	0006801	biological_process	superoxide metabolic process
I	0006879	biological_process	intracellular iron ion homeostasis
I	0006915	biological_process	apoptotic process
I	0006979	biological_process	response to oxidative stress
I	0007283	biological_process	spermatogenesis
I	0007566	biological_process	embryo implantation
I	0007605	biological_process	sensory perception of sound
I	0007626	biological_process	locomotory behavior
I	0008089	biological_process	anterograde axonal transport
I	0008090	biological_process	retrograde axonal transport
I	0008217	biological_process	regulation of blood pressure
I	0008270	molecular_function	zinc ion binding
I	0008340	biological_process	determination of adult lifespan
I	0009408	biological_process	response to heat
I	0009410	biological_process	response to xenobiotic stimulus
I	0010467	biological_process	gene expression
I	0016209	molecular_function	antioxidant activity
I	0016491	molecular_function	oxidoreductase activity
I	0019226	biological_process	transmission of nerve impulse
I	0019228	biological_process	neuronal action potential
I	0019430	biological_process	removal of superoxide radicals
I	0019899	molecular_function	enzyme binding
I	0030141	cellular_component	secretory granule
I	0030346	molecular_function	protein phosphatase 2B binding
I	0031045	cellular_component	dense core granule
I	0031267	molecular_function	small GTPase binding
I	0031410	cellular_component	cytoplasmic vesicle
I	0031667	biological_process	response to nutrient levels
I	0032287	biological_process	peripheral nervous system myelin maintenance
I	0032839	cellular_component	dendrite cytoplasm
I	0032930	biological_process	positive regulation of superoxide anion generation
I	0032991	cellular_component	protein-containing complex
I	0033081	biological_process	regulation of T cell differentiation in thymus
I	0034465	biological_process	response to carbon monoxide
I	0034599	biological_process	cellular response to oxidative stress
I	0035234	biological_process	ectopic germ cell programmed cell death
I	0035865	biological_process	cellular response to potassium ion
I	0040014	biological_process	regulation of multicellular organism growth
I	0042542	biological_process	response to hydrogen peroxide
I	0042554	biological_process	superoxide anion generation
I	0042802	molecular_function	identical protein binding
I	0042803	molecular_function	protein homodimerization activity
I	0043025	cellular_component	neuronal cell body
I	0043065	biological_process	positive regulation of apoptotic process
I	0043066	biological_process	negative regulation of apoptotic process
I	0043087	biological_process	regulation of GTPase activity
I	0043410	biological_process	positive regulation of MAPK cascade
I	0043524	biological_process	negative regulation of neuron apoptotic process
I	0045471	biological_process	response to ethanol
I	0046620	biological_process	regulation of organ growth
I	0046688	biological_process	response to copper ion
I	0046716	biological_process	muscle cell cellular homeostasis
I	0046872	molecular_function	metal ion binding
I	0048538	biological_process	thymus development
I	0048678	biological_process	response to axon injury
I	0050665	biological_process	hydrogen peroxide biosynthetic process
I	0050728	biological_process	negative regulation of inflammatory response
I	0050766	biological_process	positive regulation of phagocytosis
I	0051087	molecular_function	protein-folding chaperone binding
I	0051093	biological_process	negative regulation of developmental process
I	0051881	biological_process	regulation of mitochondrial membrane potential
I	0060047	biological_process	heart contraction
I	0060052	biological_process	neurofilament cytoskeleton organization
I	0060087	biological_process	relaxation of vascular associated smooth muscle
I	0060088	biological_process	auditory receptor cell stereocilium organization
I	0070062	cellular_component	extracellular exosome
I	0071276	biological_process	cellular response to cadmium ion
I	0071318	biological_process	cellular response to ATP
I	0072593	biological_process	reactive oxygen species metabolic process
I	0097332	biological_process	response to antipsychotic drug
I	0099610	biological_process	action potential initiation
I	1902177	biological_process	positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
I	1904115	cellular_component	axon cytoplasm
I	2000242	biological_process	negative regulation of reproductive process
J	0000302	biological_process	response to reactive oxygen species
J	0000303	biological_process	response to superoxide
J	0001541	biological_process	ovarian follicle development
J	0001819	biological_process	positive regulation of cytokine production
J	0001890	biological_process	placenta development
J	0001895	biological_process	retina homeostasis
J	0001975	biological_process	response to amphetamine
J	0002262	biological_process	myeloid cell homeostasis
J	0004784	molecular_function	superoxide dismutase activity
J	0005507	molecular_function	copper ion binding
J	0005515	molecular_function	protein binding
J	0005576	cellular_component	extracellular region
J	0005615	cellular_component	extracellular space
J	0005634	cellular_component	nucleus
J	0005654	cellular_component	nucleoplasm
J	0005737	cellular_component	cytoplasm
J	0005739	cellular_component	mitochondrion
J	0005758	cellular_component	mitochondrial intermembrane space
J	0005759	cellular_component	mitochondrial matrix
J	0005764	cellular_component	lysosome
J	0005777	cellular_component	peroxisome
J	0005829	cellular_component	cytosol
J	0005886	cellular_component	plasma membrane
J	0006749	biological_process	glutathione metabolic process
J	0006801	biological_process	superoxide metabolic process
J	0006879	biological_process	intracellular iron ion homeostasis
J	0006915	biological_process	apoptotic process
J	0006979	biological_process	response to oxidative stress
J	0007283	biological_process	spermatogenesis
J	0007566	biological_process	embryo implantation
J	0007605	biological_process	sensory perception of sound
J	0007626	biological_process	locomotory behavior
J	0008089	biological_process	anterograde axonal transport
J	0008090	biological_process	retrograde axonal transport
J	0008217	biological_process	regulation of blood pressure
J	0008270	molecular_function	zinc ion binding
J	0008340	biological_process	determination of adult lifespan
J	0009408	biological_process	response to heat
J	0009410	biological_process	response to xenobiotic stimulus
J	0010467	biological_process	gene expression
J	0016209	molecular_function	antioxidant activity
J	0016491	molecular_function	oxidoreductase activity
J	0019226	biological_process	transmission of nerve impulse
J	0019228	biological_process	neuronal action potential
J	0019430	biological_process	removal of superoxide radicals
J	0019899	molecular_function	enzyme binding
J	0030141	cellular_component	secretory granule
J	0030346	molecular_function	protein phosphatase 2B binding
J	0031045	cellular_component	dense core granule
J	0031267	molecular_function	small GTPase binding
J	0031410	cellular_component	cytoplasmic vesicle
J	0031667	biological_process	response to nutrient levels
J	0032287	biological_process	peripheral nervous system myelin maintenance
J	0032839	cellular_component	dendrite cytoplasm
J	0032930	biological_process	positive regulation of superoxide anion generation
J	0032991	cellular_component	protein-containing complex
J	0033081	biological_process	regulation of T cell differentiation in thymus
J	0034465	biological_process	response to carbon monoxide
J	0034599	biological_process	cellular response to oxidative stress
J	0035234	biological_process	ectopic germ cell programmed cell death
J	0035865	biological_process	cellular response to potassium ion
J	0040014	biological_process	regulation of multicellular organism growth
J	0042542	biological_process	response to hydrogen peroxide
J	0042554	biological_process	superoxide anion generation
J	0042802	molecular_function	identical protein binding
J	0042803	molecular_function	protein homodimerization activity
J	0043025	cellular_component	neuronal cell body
J	0043065	biological_process	positive regulation of apoptotic process
J	0043066	biological_process	negative regulation of apoptotic process
J	0043087	biological_process	regulation of GTPase activity
J	0043410	biological_process	positive regulation of MAPK cascade
J	0043524	biological_process	negative regulation of neuron apoptotic process
J	0045471	biological_process	response to ethanol
J	0046620	biological_process	regulation of organ growth
J	0046688	biological_process	response to copper ion
J	0046716	biological_process	muscle cell cellular homeostasis
J	0046872	molecular_function	metal ion binding
J	0048538	biological_process	thymus development
J	0048678	biological_process	response to axon injury
J	0050665	biological_process	hydrogen peroxide biosynthetic process
J	0050728	biological_process	negative regulation of inflammatory response
J	0050766	biological_process	positive regulation of phagocytosis
J	0051087	molecular_function	protein-folding chaperone binding
J	0051093	biological_process	negative regulation of developmental process
J	0051881	biological_process	regulation of mitochondrial membrane potential
J	0060047	biological_process	heart contraction
J	0060052	biological_process	neurofilament cytoskeleton organization
J	0060087	biological_process	relaxation of vascular associated smooth muscle
J	0060088	biological_process	auditory receptor cell stereocilium organization
J	0070062	cellular_component	extracellular exosome
J	0071276	biological_process	cellular response to cadmium ion
J	0071318	biological_process	cellular response to ATP
J	0072593	biological_process	reactive oxygen species metabolic process
J	0097332	biological_process	response to antipsychotic drug
J	0099610	biological_process	action potential initiation
J	1902177	biological_process	positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
J	1904115	cellular_component	axon cytoplasm
J	2000242	biological_process	negative regulation of reproductive process
K	0000302	biological_process	response to reactive oxygen species
K	0000303	biological_process	response to superoxide
K	0001541	biological_process	ovarian follicle development
K	0001819	biological_process	positive regulation of cytokine production
K	0001890	biological_process	placenta development
K	0001895	biological_process	retina homeostasis
K	0001975	biological_process	response to amphetamine
K	0002262	biological_process	myeloid cell homeostasis
K	0004784	molecular_function	superoxide dismutase activity
K	0005507	molecular_function	copper ion binding
K	0005515	molecular_function	protein binding
K	0005576	cellular_component	extracellular region
K	0005615	cellular_component	extracellular space
K	0005634	cellular_component	nucleus
K	0005654	cellular_component	nucleoplasm
K	0005737	cellular_component	cytoplasm
K	0005739	cellular_component	mitochondrion
K	0005758	cellular_component	mitochondrial intermembrane space
K	0005759	cellular_component	mitochondrial matrix
K	0005764	cellular_component	lysosome
K	0005777	cellular_component	peroxisome
K	0005829	cellular_component	cytosol
K	0005886	cellular_component	plasma membrane
K	0006749	biological_process	glutathione metabolic process
K	0006801	biological_process	superoxide metabolic process
K	0006879	biological_process	intracellular iron ion homeostasis
K	0006915	biological_process	apoptotic process
K	0006979	biological_process	response to oxidative stress
K	0007283	biological_process	spermatogenesis
K	0007566	biological_process	embryo implantation
K	0007605	biological_process	sensory perception of sound
K	0007626	biological_process	locomotory behavior
K	0008089	biological_process	anterograde axonal transport
K	0008090	biological_process	retrograde axonal transport
K	0008217	biological_process	regulation of blood pressure
K	0008270	molecular_function	zinc ion binding
K	0008340	biological_process	determination of adult lifespan
K	0009408	biological_process	response to heat
K	0009410	biological_process	response to xenobiotic stimulus
K	0010467	biological_process	gene expression
K	0016209	molecular_function	antioxidant activity
K	0016491	molecular_function	oxidoreductase activity
K	0019226	biological_process	transmission of nerve impulse
K	0019228	biological_process	neuronal action potential
K	0019430	biological_process	removal of superoxide radicals
K	0019899	molecular_function	enzyme binding
K	0030141	cellular_component	secretory granule
K	0030346	molecular_function	protein phosphatase 2B binding
K	0031045	cellular_component	dense core granule
K	0031267	molecular_function	small GTPase binding
K	0031410	cellular_component	cytoplasmic vesicle
K	0031667	biological_process	response to nutrient levels
K	0032287	biological_process	peripheral nervous system myelin maintenance
K	0032839	cellular_component	dendrite cytoplasm
K	0032930	biological_process	positive regulation of superoxide anion generation
K	0032991	cellular_component	protein-containing complex
K	0033081	biological_process	regulation of T cell differentiation in thymus
K	0034465	biological_process	response to carbon monoxide
K	0034599	biological_process	cellular response to oxidative stress
K	0035234	biological_process	ectopic germ cell programmed cell death
K	0035865	biological_process	cellular response to potassium ion
K	0040014	biological_process	regulation of multicellular organism growth
K	0042542	biological_process	response to hydrogen peroxide
K	0042554	biological_process	superoxide anion generation
K	0042802	molecular_function	identical protein binding
K	0042803	molecular_function	protein homodimerization activity
K	0043025	cellular_component	neuronal cell body
K	0043065	biological_process	positive regulation of apoptotic process
K	0043066	biological_process	negative regulation of apoptotic process
K	0043087	biological_process	regulation of GTPase activity
K	0043410	biological_process	positive regulation of MAPK cascade
K	0043524	biological_process	negative regulation of neuron apoptotic process
K	0045471	biological_process	response to ethanol
K	0046620	biological_process	regulation of organ growth
K	0046688	biological_process	response to copper ion
K	0046716	biological_process	muscle cell cellular homeostasis
K	0046872	molecular_function	metal ion binding
K	0048538	biological_process	thymus development
K	0048678	biological_process	response to axon injury
K	0050665	biological_process	hydrogen peroxide biosynthetic process
K	0050728	biological_process	negative regulation of inflammatory response
K	0050766	biological_process	positive regulation of phagocytosis
K	0051087	molecular_function	protein-folding chaperone binding
K	0051093	biological_process	negative regulation of developmental process
K	0051881	biological_process	regulation of mitochondrial membrane potential
K	0060047	biological_process	heart contraction
K	0060052	biological_process	neurofilament cytoskeleton organization
K	0060087	biological_process	relaxation of vascular associated smooth muscle
K	0060088	biological_process	auditory receptor cell stereocilium organization
K	0070062	cellular_component	extracellular exosome
K	0071276	biological_process	cellular response to cadmium ion
K	0071318	biological_process	cellular response to ATP
K	0072593	biological_process	reactive oxygen species metabolic process
K	0097332	biological_process	response to antipsychotic drug
K	0099610	biological_process	action potential initiation
K	1902177	biological_process	positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
K	1904115	cellular_component	axon cytoplasm
K	2000242	biological_process	negative regulation of reproductive process
L	0000302	biological_process	response to reactive oxygen species
L	0000303	biological_process	response to superoxide
L	0001541	biological_process	ovarian follicle development
L	0001819	biological_process	positive regulation of cytokine production
L	0001890	biological_process	placenta development
L	0001895	biological_process	retina homeostasis
L	0001975	biological_process	response to amphetamine
L	0002262	biological_process	myeloid cell homeostasis
L	0004784	molecular_function	superoxide dismutase activity
L	0005507	molecular_function	copper ion binding
L	0005515	molecular_function	protein binding
L	0005576	cellular_component	extracellular region
L	0005615	cellular_component	extracellular space
L	0005634	cellular_component	nucleus
L	0005654	cellular_component	nucleoplasm
L	0005737	cellular_component	cytoplasm
L	0005739	cellular_component	mitochondrion
L	0005758	cellular_component	mitochondrial intermembrane space
L	0005759	cellular_component	mitochondrial matrix
L	0005764	cellular_component	lysosome
L	0005777	cellular_component	peroxisome
L	0005829	cellular_component	cytosol
L	0005886	cellular_component	plasma membrane
L	0006749	biological_process	glutathione metabolic process
L	0006801	biological_process	superoxide metabolic process
L	0006879	biological_process	intracellular iron ion homeostasis
L	0006915	biological_process	apoptotic process
L	0006979	biological_process	response to oxidative stress
L	0007283	biological_process	spermatogenesis
L	0007566	biological_process	embryo implantation
L	0007605	biological_process	sensory perception of sound
L	0007626	biological_process	locomotory behavior
L	0008089	biological_process	anterograde axonal transport
L	0008090	biological_process	retrograde axonal transport
L	0008217	biological_process	regulation of blood pressure
L	0008270	molecular_function	zinc ion binding
L	0008340	biological_process	determination of adult lifespan
L	0009408	biological_process	response to heat
L	0009410	biological_process	response to xenobiotic stimulus
L	0010467	biological_process	gene expression
L	0016209	molecular_function	antioxidant activity
L	0016491	molecular_function	oxidoreductase activity
L	0019226	biological_process	transmission of nerve impulse
L	0019228	biological_process	neuronal action potential
L	0019430	biological_process	removal of superoxide radicals
L	0019899	molecular_function	enzyme binding
L	0030141	cellular_component	secretory granule
L	0030346	molecular_function	protein phosphatase 2B binding
L	0031045	cellular_component	dense core granule
L	0031267	molecular_function	small GTPase binding
L	0031410	cellular_component	cytoplasmic vesicle
L	0031667	biological_process	response to nutrient levels
L	0032287	biological_process	peripheral nervous system myelin maintenance
L	0032839	cellular_component	dendrite cytoplasm
L	0032930	biological_process	positive regulation of superoxide anion generation
L	0032991	cellular_component	protein-containing complex
L	0033081	biological_process	regulation of T cell differentiation in thymus
L	0034465	biological_process	response to carbon monoxide
L	0034599	biological_process	cellular response to oxidative stress
L	0035234	biological_process	ectopic germ cell programmed cell death
L	0035865	biological_process	cellular response to potassium ion
L	0040014	biological_process	regulation of multicellular organism growth
L	0042542	biological_process	response to hydrogen peroxide
L	0042554	biological_process	superoxide anion generation
L	0042802	molecular_function	identical protein binding
L	0042803	molecular_function	protein homodimerization activity
L	0043025	cellular_component	neuronal cell body
L	0043065	biological_process	positive regulation of apoptotic process
L	0043066	biological_process	negative regulation of apoptotic process
L	0043087	biological_process	regulation of GTPase activity
L	0043410	biological_process	positive regulation of MAPK cascade
L	0043524	biological_process	negative regulation of neuron apoptotic process
L	0045471	biological_process	response to ethanol
L	0046620	biological_process	regulation of organ growth
L	0046688	biological_process	response to copper ion
L	0046716	biological_process	muscle cell cellular homeostasis
L	0046872	molecular_function	metal ion binding
L	0048538	biological_process	thymus development
L	0048678	biological_process	response to axon injury
L	0050665	biological_process	hydrogen peroxide biosynthetic process
L	0050728	biological_process	negative regulation of inflammatory response
L	0050766	biological_process	positive regulation of phagocytosis
L	0051087	molecular_function	protein-folding chaperone binding
L	0051093	biological_process	negative regulation of developmental process
L	0051881	biological_process	regulation of mitochondrial membrane potential
L	0060047	biological_process	heart contraction
L	0060052	biological_process	neurofilament cytoskeleton organization
L	0060087	biological_process	relaxation of vascular associated smooth muscle
L	0060088	biological_process	auditory receptor cell stereocilium organization
L	0070062	cellular_component	extracellular exosome
L	0071276	biological_process	cellular response to cadmium ion
L	0071318	biological_process	cellular response to ATP
L	0072593	biological_process	reactive oxygen species metabolic process
L	0097332	biological_process	response to antipsychotic drug
L	0099610	biological_process	action potential initiation
L	1902177	biological_process	positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
L	1904115	cellular_component	axon cytoplasm
L	2000242	biological_process	negative regulation of reproductive process
M	0000302	biological_process	response to reactive oxygen species
M	0000303	biological_process	response to superoxide
M	0001541	biological_process	ovarian follicle development
M	0001819	biological_process	positive regulation of cytokine production
M	0001890	biological_process	placenta development
M	0001895	biological_process	retina homeostasis
M	0001975	biological_process	response to amphetamine
M	0002262	biological_process	myeloid cell homeostasis
M	0004784	molecular_function	superoxide dismutase activity
M	0005507	molecular_function	copper ion binding
M	0005515	molecular_function	protein binding
M	0005576	cellular_component	extracellular region
M	0005615	cellular_component	extracellular space
M	0005634	cellular_component	nucleus
M	0005654	cellular_component	nucleoplasm
M	0005737	cellular_component	cytoplasm
M	0005739	cellular_component	mitochondrion
M	0005758	cellular_component	mitochondrial intermembrane space
M	0005759	cellular_component	mitochondrial matrix
M	0005764	cellular_component	lysosome
M	0005777	cellular_component	peroxisome
M	0005829	cellular_component	cytosol
M	0005886	cellular_component	plasma membrane
M	0006749	biological_process	glutathione metabolic process
M	0006801	biological_process	superoxide metabolic process
M	0006879	biological_process	intracellular iron ion homeostasis
M	0006915	biological_process	apoptotic process
M	0006979	biological_process	response to oxidative stress
M	0007283	biological_process	spermatogenesis
M	0007566	biological_process	embryo implantation
M	0007605	biological_process	sensory perception of sound
M	0007626	biological_process	locomotory behavior
M	0008089	biological_process	anterograde axonal transport
M	0008090	biological_process	retrograde axonal transport
M	0008217	biological_process	regulation of blood pressure
M	0008270	molecular_function	zinc ion binding
M	0008340	biological_process	determination of adult lifespan
M	0009408	biological_process	response to heat
M	0009410	biological_process	response to xenobiotic stimulus
M	0010467	biological_process	gene expression
M	0016209	molecular_function	antioxidant activity
M	0016491	molecular_function	oxidoreductase activity
M	0019226	biological_process	transmission of nerve impulse
M	0019228	biological_process	neuronal action potential
M	0019430	biological_process	removal of superoxide radicals
M	0019899	molecular_function	enzyme binding
M	0030141	cellular_component	secretory granule
M	0030346	molecular_function	protein phosphatase 2B binding
M	0031045	cellular_component	dense core granule
M	0031267	molecular_function	small GTPase binding
M	0031410	cellular_component	cytoplasmic vesicle
M	0031667	biological_process	response to nutrient levels
M	0032287	biological_process	peripheral nervous system myelin maintenance
M	0032839	cellular_component	dendrite cytoplasm
M	0032930	biological_process	positive regulation of superoxide anion generation
M	0032991	cellular_component	protein-containing complex
M	0033081	biological_process	regulation of T cell differentiation in thymus
M	0034465	biological_process	response to carbon monoxide
M	0034599	biological_process	cellular response to oxidative stress
M	0035234	biological_process	ectopic germ cell programmed cell death
M	0035865	biological_process	cellular response to potassium ion
M	0040014	biological_process	regulation of multicellular organism growth
M	0042542	biological_process	response to hydrogen peroxide
M	0042554	biological_process	superoxide anion generation
M	0042802	molecular_function	identical protein binding
M	0042803	molecular_function	protein homodimerization activity
M	0043025	cellular_component	neuronal cell body
M	0043065	biological_process	positive regulation of apoptotic process
M	0043066	biological_process	negative regulation of apoptotic process
M	0043087	biological_process	regulation of GTPase activity
M	0043410	biological_process	positive regulation of MAPK cascade
M	0043524	biological_process	negative regulation of neuron apoptotic process
M	0045471	biological_process	response to ethanol
M	0046620	biological_process	regulation of organ growth
M	0046688	biological_process	response to copper ion
M	0046716	biological_process	muscle cell cellular homeostasis
M	0046872	molecular_function	metal ion binding
M	0048538	biological_process	thymus development
M	0048678	biological_process	response to axon injury
M	0050665	biological_process	hydrogen peroxide biosynthetic process
M	0050728	biological_process	negative regulation of inflammatory response
M	0050766	biological_process	positive regulation of phagocytosis
M	0051087	molecular_function	protein-folding chaperone binding
M	0051093	biological_process	negative regulation of developmental process
M	0051881	biological_process	regulation of mitochondrial membrane potential
M	0060047	biological_process	heart contraction
M	0060052	biological_process	neurofilament cytoskeleton organization
M	0060087	biological_process	relaxation of vascular associated smooth muscle
M	0060088	biological_process	auditory receptor cell stereocilium organization
M	0070062	cellular_component	extracellular exosome
M	0071276	biological_process	cellular response to cadmium ion
M	0071318	biological_process	cellular response to ATP
M	0072593	biological_process	reactive oxygen species metabolic process
M	0097332	biological_process	response to antipsychotic drug
M	0099610	biological_process	action potential initiation
M	1902177	biological_process	positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
M	1904115	cellular_component	axon cytoplasm
M	2000242	biological_process	negative regulation of reproductive process
N	0000302	biological_process	response to reactive oxygen species
N	0000303	biological_process	response to superoxide
N	0001541	biological_process	ovarian follicle development
N	0001819	biological_process	positive regulation of cytokine production
N	0001890	biological_process	placenta development
N	0001895	biological_process	retina homeostasis
N	0001975	biological_process	response to amphetamine
N	0002262	biological_process	myeloid cell homeostasis
N	0004784	molecular_function	superoxide dismutase activity
N	0005507	molecular_function	copper ion binding
N	0005515	molecular_function	protein binding
N	0005576	cellular_component	extracellular region
N	0005615	cellular_component	extracellular space
N	0005634	cellular_component	nucleus
N	0005654	cellular_component	nucleoplasm
N	0005737	cellular_component	cytoplasm
N	0005739	cellular_component	mitochondrion
N	0005758	cellular_component	mitochondrial intermembrane space
N	0005759	cellular_component	mitochondrial matrix
N	0005764	cellular_component	lysosome
N	0005777	cellular_component	peroxisome
N	0005829	cellular_component	cytosol
N	0005886	cellular_component	plasma membrane
N	0006749	biological_process	glutathione metabolic process
N	0006801	biological_process	superoxide metabolic process
N	0006879	biological_process	intracellular iron ion homeostasis
N	0006915	biological_process	apoptotic process
N	0006979	biological_process	response to oxidative stress
N	0007283	biological_process	spermatogenesis
N	0007566	biological_process	embryo implantation
N	0007605	biological_process	sensory perception of sound
N	0007626	biological_process	locomotory behavior
N	0008089	biological_process	anterograde axonal transport
N	0008090	biological_process	retrograde axonal transport
N	0008217	biological_process	regulation of blood pressure
N	0008270	molecular_function	zinc ion binding
N	0008340	biological_process	determination of adult lifespan
N	0009408	biological_process	response to heat
N	0009410	biological_process	response to xenobiotic stimulus
N	0010467	biological_process	gene expression
N	0016209	molecular_function	antioxidant activity
N	0016491	molecular_function	oxidoreductase activity
N	0019226	biological_process	transmission of nerve impulse
N	0019228	biological_process	neuronal action potential
N	0019430	biological_process	removal of superoxide radicals
N	0019899	molecular_function	enzyme binding
N	0030141	cellular_component	secretory granule
N	0030346	molecular_function	protein phosphatase 2B binding
N	0031045	cellular_component	dense core granule
N	0031267	molecular_function	small GTPase binding
N	0031410	cellular_component	cytoplasmic vesicle
N	0031667	biological_process	response to nutrient levels
N	0032287	biological_process	peripheral nervous system myelin maintenance
N	0032839	cellular_component	dendrite cytoplasm
N	0032930	biological_process	positive regulation of superoxide anion generation
N	0032991	cellular_component	protein-containing complex
N	0033081	biological_process	regulation of T cell differentiation in thymus
N	0034465	biological_process	response to carbon monoxide
N	0034599	biological_process	cellular response to oxidative stress
N	0035234	biological_process	ectopic germ cell programmed cell death
N	0035865	biological_process	cellular response to potassium ion
N	0040014	biological_process	regulation of multicellular organism growth
N	0042542	biological_process	response to hydrogen peroxide
N	0042554	biological_process	superoxide anion generation
N	0042802	molecular_function	identical protein binding
N	0042803	molecular_function	protein homodimerization activity
N	0043025	cellular_component	neuronal cell body
N	0043065	biological_process	positive regulation of apoptotic process
N	0043066	biological_process	negative regulation of apoptotic process
N	0043087	biological_process	regulation of GTPase activity
N	0043410	biological_process	positive regulation of MAPK cascade
N	0043524	biological_process	negative regulation of neuron apoptotic process
N	0045471	biological_process	response to ethanol
N	0046620	biological_process	regulation of organ growth
N	0046688	biological_process	response to copper ion
N	0046716	biological_process	muscle cell cellular homeostasis
N	0046872	molecular_function	metal ion binding
N	0048538	biological_process	thymus development
N	0048678	biological_process	response to axon injury
N	0050665	biological_process	hydrogen peroxide biosynthetic process
N	0050728	biological_process	negative regulation of inflammatory response
N	0050766	biological_process	positive regulation of phagocytosis
N	0051087	molecular_function	protein-folding chaperone binding
N	0051093	biological_process	negative regulation of developmental process
N	0051881	biological_process	regulation of mitochondrial membrane potential
N	0060047	biological_process	heart contraction
N	0060052	biological_process	neurofilament cytoskeleton organization
N	0060087	biological_process	relaxation of vascular associated smooth muscle
N	0060088	biological_process	auditory receptor cell stereocilium organization
N	0070062	cellular_component	extracellular exosome
N	0071276	biological_process	cellular response to cadmium ion
N	0071318	biological_process	cellular response to ATP
N	0072593	biological_process	reactive oxygen species metabolic process
N	0097332	biological_process	response to antipsychotic drug
N	0099610	biological_process	action potential initiation
N	1902177	biological_process	positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
N	1904115	cellular_component	axon cytoplasm
N	2000242	biological_process	negative regulation of reproductive process

Functional Information from PROSITE/UniProt

site_id	PS00332
Number of Residues	12
Details	SOD_CU_ZN_2 Copper/Zinc superoxide dismutase signature 2. GNAGsRlACgvI

Chain	Residue	Details
M	GLY138-ILE149

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	24
Details	Binding site: {"evidences":[{"source":"PubMed","id":"12963370","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17548825","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	26
Details	Binding site: {"evidences":[{"source":"PubMed","id":"20727846","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	8
Details	Modified residue: {"description":"N-acetylalanine","evidences":[{"source":"PubMed","id":"1463506","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7002610","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25944712","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	24
Details	Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"P08228","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	8
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	8
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	8
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P07632","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	8
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P08228","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	8
Details	Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"PubMed","id":"24140062","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	2
Details	Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"P08228","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	8
Details	Lipidation: {"description":"S-palmitoyl cysteine","evidences":[{"source":"PubMed","id":"22496122","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	16
Details	Cross-link: {"description":"1-(tryptophan-3-yl)-tryptophan (Trp-Trp) (interchain with W-33)","evidences":[{"source":"PubMed","id":"20600836","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 2jcw

Chain	Residue	Details
M	ARG143
M	HIS63

---

site_id	CSA10
Number of Residues	1
Details	Annotated By Reference To The Literature 2jcw

Chain	Residue	Details
N	HIS63

---

site_id	CSA11
Number of Residues	1
Details	Annotated By Reference To The Literature 2jcw

Chain	Residue	Details
G	HIS63

---

site_id	CSA12
Number of Residues	1
Details	Annotated By Reference To The Literature 2jcw

Chain	Residue	Details
H	HIS63

---

site_id	CSA13
Number of Residues	1
Details	Annotated By Reference To The Literature 2jcw

Chain	Residue	Details
K	HIS63

---

site_id	CSA14
Number of Residues	1
Details	Annotated By Reference To The Literature 2jcw

Chain	Residue	Details
L	HIS63

---

site_id	CSA15
Number of Residues	1
Details	Annotated By Reference To The Literature 2jcw

Chain	Residue	Details
I	HIS63

---

site_id	CSA16
Number of Residues	1
Details	Annotated By Reference To The Literature 2jcw

Chain	Residue	Details
J	HIS63

---

site_id	CSA2
Number of Residues	2
Details	Annotated By Reference To The Literature 2jcw

Chain	Residue	Details
N	ARG143
N	HIS63

---

site_id	CSA3
Number of Residues	2
Details	Annotated By Reference To The Literature 2jcw

Chain	Residue	Details
G	ARG143
G	HIS63

---

site_id	CSA4
Number of Residues	2
Details	Annotated By Reference To The Literature 2jcw

Chain	Residue	Details
H	ARG143
H	HIS63

---

site_id	CSA5
Number of Residues	2
Details	Annotated By Reference To The Literature 2jcw

Chain	Residue	Details
K	ARG143
K	HIS63

---

site_id	CSA6
Number of Residues	2
Details	Annotated By Reference To The Literature 2jcw

Chain	Residue	Details
L	ARG143
L	HIS63

---

site_id	CSA7
Number of Residues	2
Details	Annotated By Reference To The Literature 2jcw

Chain	Residue	Details
I	ARG143
I	HIS63

---

site_id	CSA8
Number of Residues	2
Details	Annotated By Reference To The Literature 2jcw

Chain	Residue	Details
J	ARG143
J	HIS63

---

site_id	CSA9
Number of Residues	1
Details	Annotated By Reference To The Literature 2jcw

Chain	Residue	Details
M	HIS63

---