1OY0

The crystal Structure of the First Enzyme of Pantothenate Biosynthetic Pathway, Ketopantoate Hydroxymethyltransferase from Mycobacterium Tuberculosis Shows a Decameric Assembly and Terminal Helix-Swapping

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000287	molecular_function	magnesium ion binding
A	0003824	molecular_function	catalytic activity
A	0003864	molecular_function	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
A	0005737	cellular_component	cytoplasm
A	0005886	cellular_component	plasma membrane
A	0015940	biological_process	pantothenate biosynthetic process
A	0016740	molecular_function	transferase activity
A	0046872	molecular_function	metal ion binding
B	0000287	molecular_function	magnesium ion binding
B	0003824	molecular_function	catalytic activity
B	0003864	molecular_function	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
B	0005737	cellular_component	cytoplasm
B	0005886	cellular_component	plasma membrane
B	0015940	biological_process	pantothenate biosynthetic process
B	0016740	molecular_function	transferase activity
B	0046872	molecular_function	metal ion binding
C	0000287	molecular_function	magnesium ion binding
C	0003824	molecular_function	catalytic activity
C	0003864	molecular_function	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
C	0005737	cellular_component	cytoplasm
C	0005886	cellular_component	plasma membrane
C	0015940	biological_process	pantothenate biosynthetic process
C	0016740	molecular_function	transferase activity
C	0046872	molecular_function	metal ion binding
D	0000287	molecular_function	magnesium ion binding
D	0003824	molecular_function	catalytic activity
D	0003864	molecular_function	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
D	0005737	cellular_component	cytoplasm
D	0005886	cellular_component	plasma membrane
D	0015940	biological_process	pantothenate biosynthetic process
D	0016740	molecular_function	transferase activity
D	0046872	molecular_function	metal ion binding
E	0000287	molecular_function	magnesium ion binding
E	0003824	molecular_function	catalytic activity
E	0003864	molecular_function	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
E	0005737	cellular_component	cytoplasm
E	0005886	cellular_component	plasma membrane
E	0015940	biological_process	pantothenate biosynthetic process
E	0016740	molecular_function	transferase activity
E	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG A 901

Chain	Residue
A	ASP62
A	GLU133
A	HOH914
A	HOH928

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG B 902

Chain	Residue
B	ASP62
B	GLU133
B	HOH911
B	HOH920

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG C 903

Chain	Residue
C	GLU133
C	HOH914
C	HOH922
C	ASP62

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG D 904

Chain	Residue
D	ASP62
D	GLU133
D	HOH917
D	HOH923

---

site_id	AC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MG E 905

Chain	Residue
E	ASP62
E	GLU133
E	HOH924

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	5
Details	Active site: {"description":"Proton acceptor","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	15
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	10
Details	Binding site: {}

Chain

Residue

Details

---