1OWT
Structure of the Alzheimer's disease amyloid precursor protein copper binding domain
Functional Information from GO Data
Functional Information from PROSITE/UniProt
| site_id | PS00319 |
| Number of Residues | 8 |
| Details | APP_CUBD Amyloid precursor protein (APP) copper-binding (CuBD) domain signature. GVEFVCCP |
| Chain | Residue | Details |
| A | GLY181-PRO188 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU01217, ECO:0000269|PubMed:17239395, ECO:0000269|PubMed:25122912, ECO:0007744|PDB:2FK1 |
| Chain | Residue | Details |
| A | HIS147 | |
| A | HIS151 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU01217, ECO:0000269|PubMed:17239395, ECO:0007744|PDB:2FK1 |
| Chain | Residue | Details |
| A | TYR168 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 3 |
| Details | BINDING: BINDING => ECO:0000305|PubMed:8344894 |
| Chain | Residue | Details |
| A | GLU183 | |
| A | CYS186 | |
| A | CYS187 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | SITE: Required for Cu(2+) reduction => ECO:0000255|PROSITE-ProRule:PRU01217 |
| Chain | Residue | Details |
| A | MET170 |
