1OVM
Crystal structure of Indolepyruvate decarboxylase from Enterobacter cloacae
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0000949 | biological_process | aromatic amino acid family catabolic process to alcohol via Ehrlich pathway |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0004737 | molecular_function | pyruvate decarboxylase activity |
| A | 0005829 | cellular_component | cytosol |
| A | 0009851 | biological_process | auxin biosynthetic process |
| A | 0016829 | molecular_function | lyase activity |
| A | 0016831 | molecular_function | carboxy-lyase activity |
| A | 0019752 | biological_process | carboxylic acid metabolic process |
| A | 0030976 | molecular_function | thiamine pyrophosphate binding |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0047434 | molecular_function | indolepyruvate decarboxylase activity |
| B | 0000287 | molecular_function | magnesium ion binding |
| B | 0000949 | biological_process | aromatic amino acid family catabolic process to alcohol via Ehrlich pathway |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0004737 | molecular_function | pyruvate decarboxylase activity |
| B | 0005829 | cellular_component | cytosol |
| B | 0009851 | biological_process | auxin biosynthetic process |
| B | 0016829 | molecular_function | lyase activity |
| B | 0016831 | molecular_function | carboxy-lyase activity |
| B | 0019752 | biological_process | carboxylic acid metabolic process |
| B | 0030976 | molecular_function | thiamine pyrophosphate binding |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0047434 | molecular_function | indolepyruvate decarboxylase activity |
| C | 0000287 | molecular_function | magnesium ion binding |
| C | 0000949 | biological_process | aromatic amino acid family catabolic process to alcohol via Ehrlich pathway |
| C | 0003824 | molecular_function | catalytic activity |
| C | 0004737 | molecular_function | pyruvate decarboxylase activity |
| C | 0005829 | cellular_component | cytosol |
| C | 0009851 | biological_process | auxin biosynthetic process |
| C | 0016829 | molecular_function | lyase activity |
| C | 0016831 | molecular_function | carboxy-lyase activity |
| C | 0019752 | biological_process | carboxylic acid metabolic process |
| C | 0030976 | molecular_function | thiamine pyrophosphate binding |
| C | 0046872 | molecular_function | metal ion binding |
| C | 0047434 | molecular_function | indolepyruvate decarboxylase activity |
| D | 0000287 | molecular_function | magnesium ion binding |
| D | 0000949 | biological_process | aromatic amino acid family catabolic process to alcohol via Ehrlich pathway |
| D | 0003824 | molecular_function | catalytic activity |
| D | 0004737 | molecular_function | pyruvate decarboxylase activity |
| D | 0005829 | cellular_component | cytosol |
| D | 0009851 | biological_process | auxin biosynthetic process |
| D | 0016829 | molecular_function | lyase activity |
| D | 0016831 | molecular_function | carboxy-lyase activity |
| D | 0019752 | biological_process | carboxylic acid metabolic process |
| D | 0030976 | molecular_function | thiamine pyrophosphate binding |
| D | 0046872 | molecular_function | metal ion binding |
| D | 0047434 | molecular_function | indolepyruvate decarboxylase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG A 601 |
| Chain | Residue |
| A | ASP435 |
| A | LEU460 |
| A | ASN462 |
| A | GLY464 |
| A | TPP600 |
| A | HOH647 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG B 601 |
| Chain | Residue |
| B | GLY464 |
| B | TPP600 |
| B | HOH660 |
| B | ASP435 |
| B | LEU460 |
| B | ASN462 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG C 601 |
| Chain | Residue |
| C | ASP435 |
| C | LEU460 |
| C | ASN462 |
| C | GLY464 |
| C | TPP600 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG D 601 |
| Chain | Residue |
| D | ASP435 |
| D | LEU460 |
| D | ASN462 |
| D | GLY464 |
| D | TPP600 |
| site_id | AC5 |
| Number of Residues | 24 |
| Details | BINDING SITE FOR RESIDUE TPP A 600 |
| Chain | Residue |
| A | GLY384 |
| A | THR385 |
| A | GLY408 |
| A | SER409 |
| A | ILE410 |
| A | GLY434 |
| A | ASP435 |
| A | GLY436 |
| A | ALA437 |
| A | ASN462 |
| A | GLY464 |
| A | TYR465 |
| A | THR466 |
| A | VAL467 |
| A | MG601 |
| A | HOH608 |
| A | HOH647 |
| A | HOH659 |
| B | VAL26 |
| B | PRO27 |
| B | GLY28 |
| B | GLU52 |
| B | VAL77 |
| B | HIS116 |
| site_id | AC6 |
| Number of Residues | 24 |
| Details | BINDING SITE FOR RESIDUE TPP B 600 |
| Chain | Residue |
| A | VAL26 |
| A | PRO27 |
| A | GLY28 |
| A | GLU52 |
| A | VAL77 |
| A | HIS116 |
| B | GLY384 |
| B | THR385 |
| B | GLY408 |
| B | SER409 |
| B | ILE410 |
| B | GLY434 |
| B | ASP435 |
| B | GLY436 |
| B | ALA437 |
| B | ASN462 |
| B | GLY464 |
| B | TYR465 |
| B | THR466 |
| B | VAL467 |
| B | MG601 |
| B | HOH607 |
| B | HOH616 |
| B | HOH660 |
| site_id | AC7 |
| Number of Residues | 22 |
| Details | BINDING SITE FOR RESIDUE TPP C 600 |
| Chain | Residue |
| C | GLY384 |
| C | THR385 |
| C | GLY408 |
| C | SER409 |
| C | ILE410 |
| C | GLY434 |
| C | ASP435 |
| C | GLY436 |
| C | ALA437 |
| C | ASN462 |
| C | GLY464 |
| C | TYR465 |
| C | THR466 |
| C | VAL467 |
| C | MG601 |
| C | HOH617 |
| C | HOH641 |
| D | VAL26 |
| D | PRO27 |
| D | GLU52 |
| D | VAL77 |
| D | HIS116 |
| site_id | AC8 |
| Number of Residues | 22 |
| Details | BINDING SITE FOR RESIDUE TPP D 600 |
| Chain | Residue |
| D | THR385 |
| D | GLY408 |
| D | SER409 |
| D | ILE410 |
| D | GLY434 |
| D | ASP435 |
| D | GLY436 |
| D | ALA437 |
| D | ASN462 |
| D | GLY464 |
| D | TYR465 |
| D | THR466 |
| D | VAL467 |
| D | MG601 |
| D | HOH658 |
| C | VAL26 |
| C | PRO27 |
| C | GLY28 |
| C | GLU52 |
| C | VAL77 |
| C | HIS116 |
| D | GLY384 |
Functional Information from PROSITE/UniProt
| site_id | PS00187 |
| Number of Residues | 20 |
| Details | TPP_ENZYMES Thiamine pyrophosphate enzymes signature. FGaqtacPnrrvIvLtGDGA |
| Chain | Residue | Details |
| A | PHE418-ALA437 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 324 |
| Details | Region: {"description":"Thiamine pyrophosphate binding"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 12 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"12752451","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1dtw |
| Chain | Residue | Details |
| A | PRO536 |
| site_id | CSA2 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1dtw |
| Chain | Residue | Details |
| B | PRO536 |
| site_id | CSA3 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1dtw |
| Chain | Residue | Details |
| C | PRO536 |
| site_id | CSA4 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1dtw |
| Chain | Residue | Details |
| D | PRO536 |
| site_id | CSA5 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1dtw |
| Chain | Residue | Details |
| A | HIS116 | |
| A | GLU468 | |
| A | HIS115 | |
| A | ASP29 |
| site_id | CSA6 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1dtw |
| Chain | Residue | Details |
| B | HIS116 | |
| B | GLU468 | |
| B | HIS115 | |
| B | ASP29 |
| site_id | CSA7 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1dtw |
| Chain | Residue | Details |
| C | HIS116 | |
| C | GLU468 | |
| C | HIS115 | |
| C | ASP29 |
| site_id | CSA8 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1dtw |
| Chain | Residue | Details |
| D | HIS116 | |
| D | GLU468 | |
| D | HIS115 | |
| D | ASP29 |
