1OVM
Crystal structure of Indolepyruvate decarboxylase from Enterobacter cloacae
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0000287 | molecular_function | magnesium ion binding |
A | 0000949 | biological_process | aromatic amino acid family catabolic process to alcohol via Ehrlich pathway |
A | 0003824 | molecular_function | catalytic activity |
A | 0004737 | molecular_function | pyruvate decarboxylase activity |
A | 0005829 | cellular_component | cytosol |
A | 0009851 | biological_process | auxin biosynthetic process |
A | 0016831 | molecular_function | carboxy-lyase activity |
A | 0019752 | biological_process | carboxylic acid metabolic process |
A | 0030976 | molecular_function | thiamine pyrophosphate binding |
A | 0046872 | molecular_function | metal ion binding |
A | 0047434 | molecular_function | indolepyruvate decarboxylase activity |
B | 0000287 | molecular_function | magnesium ion binding |
B | 0000949 | biological_process | aromatic amino acid family catabolic process to alcohol via Ehrlich pathway |
B | 0003824 | molecular_function | catalytic activity |
B | 0004737 | molecular_function | pyruvate decarboxylase activity |
B | 0005829 | cellular_component | cytosol |
B | 0009851 | biological_process | auxin biosynthetic process |
B | 0016831 | molecular_function | carboxy-lyase activity |
B | 0019752 | biological_process | carboxylic acid metabolic process |
B | 0030976 | molecular_function | thiamine pyrophosphate binding |
B | 0046872 | molecular_function | metal ion binding |
B | 0047434 | molecular_function | indolepyruvate decarboxylase activity |
C | 0000287 | molecular_function | magnesium ion binding |
C | 0000949 | biological_process | aromatic amino acid family catabolic process to alcohol via Ehrlich pathway |
C | 0003824 | molecular_function | catalytic activity |
C | 0004737 | molecular_function | pyruvate decarboxylase activity |
C | 0005829 | cellular_component | cytosol |
C | 0009851 | biological_process | auxin biosynthetic process |
C | 0016831 | molecular_function | carboxy-lyase activity |
C | 0019752 | biological_process | carboxylic acid metabolic process |
C | 0030976 | molecular_function | thiamine pyrophosphate binding |
C | 0046872 | molecular_function | metal ion binding |
C | 0047434 | molecular_function | indolepyruvate decarboxylase activity |
D | 0000287 | molecular_function | magnesium ion binding |
D | 0000949 | biological_process | aromatic amino acid family catabolic process to alcohol via Ehrlich pathway |
D | 0003824 | molecular_function | catalytic activity |
D | 0004737 | molecular_function | pyruvate decarboxylase activity |
D | 0005829 | cellular_component | cytosol |
D | 0009851 | biological_process | auxin biosynthetic process |
D | 0016831 | molecular_function | carboxy-lyase activity |
D | 0019752 | biological_process | carboxylic acid metabolic process |
D | 0030976 | molecular_function | thiamine pyrophosphate binding |
D | 0046872 | molecular_function | metal ion binding |
D | 0047434 | molecular_function | indolepyruvate decarboxylase activity |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE MG A 601 |
Chain | Residue |
A | ASP435 |
A | LEU460 |
A | ASN462 |
A | GLY464 |
A | TPP600 |
A | HOH647 |
site_id | AC2 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE MG B 601 |
Chain | Residue |
B | GLY464 |
B | TPP600 |
B | HOH660 |
B | ASP435 |
B | LEU460 |
B | ASN462 |
site_id | AC3 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE MG C 601 |
Chain | Residue |
C | ASP435 |
C | LEU460 |
C | ASN462 |
C | GLY464 |
C | TPP600 |
site_id | AC4 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE MG D 601 |
Chain | Residue |
D | ASP435 |
D | LEU460 |
D | ASN462 |
D | GLY464 |
D | TPP600 |
site_id | AC5 |
Number of Residues | 24 |
Details | BINDING SITE FOR RESIDUE TPP A 600 |
Chain | Residue |
A | GLY384 |
A | THR385 |
A | GLY408 |
A | SER409 |
A | ILE410 |
A | GLY434 |
A | ASP435 |
A | GLY436 |
A | ALA437 |
A | ASN462 |
A | GLY464 |
A | TYR465 |
A | THR466 |
A | VAL467 |
A | MG601 |
A | HOH608 |
A | HOH647 |
A | HOH659 |
B | VAL26 |
B | PRO27 |
B | GLY28 |
B | GLU52 |
B | VAL77 |
B | HIS116 |
site_id | AC6 |
Number of Residues | 24 |
Details | BINDING SITE FOR RESIDUE TPP B 600 |
Chain | Residue |
A | VAL26 |
A | PRO27 |
A | GLY28 |
A | GLU52 |
A | VAL77 |
A | HIS116 |
B | GLY384 |
B | THR385 |
B | GLY408 |
B | SER409 |
B | ILE410 |
B | GLY434 |
B | ASP435 |
B | GLY436 |
B | ALA437 |
B | ASN462 |
B | GLY464 |
B | TYR465 |
B | THR466 |
B | VAL467 |
B | MG601 |
B | HOH607 |
B | HOH616 |
B | HOH660 |
site_id | AC7 |
Number of Residues | 22 |
Details | BINDING SITE FOR RESIDUE TPP C 600 |
Chain | Residue |
C | GLY384 |
C | THR385 |
C | GLY408 |
C | SER409 |
C | ILE410 |
C | GLY434 |
C | ASP435 |
C | GLY436 |
C | ALA437 |
C | ASN462 |
C | GLY464 |
C | TYR465 |
C | THR466 |
C | VAL467 |
C | MG601 |
C | HOH617 |
C | HOH641 |
D | VAL26 |
D | PRO27 |
D | GLU52 |
D | VAL77 |
D | HIS116 |
site_id | AC8 |
Number of Residues | 22 |
Details | BINDING SITE FOR RESIDUE TPP D 600 |
Chain | Residue |
D | THR385 |
D | GLY408 |
D | SER409 |
D | ILE410 |
D | GLY434 |
D | ASP435 |
D | GLY436 |
D | ALA437 |
D | ASN462 |
D | GLY464 |
D | TYR465 |
D | THR466 |
D | VAL467 |
D | MG601 |
D | HOH658 |
C | VAL26 |
C | PRO27 |
C | GLY28 |
C | GLU52 |
C | VAL77 |
C | HIS116 |
D | GLY384 |
Functional Information from PROSITE/UniProt
site_id | PS00187 |
Number of Residues | 20 |
Details | TPP_ENZYMES Thiamine pyrophosphate enzymes signature. FGaqtacPnrrvIvLtGDGA |
Chain | Residue | Details |
A | PHE418-ALA437 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 12 |
Details | BINDING: BINDING => ECO:0000269|PubMed:12752451 |
Chain | Residue | Details |
A | GLU52 | |
D | GLU52 | |
D | ASP435 | |
D | ASN462 | |
A | ASP435 | |
A | ASN462 | |
B | GLU52 | |
B | ASP435 | |
B | ASN462 | |
C | GLU52 | |
C | ASP435 | |
C | ASN462 |
Catalytic Information from CSA
site_id | CSA1 |
Number of Residues | 1 |
Details | Annotated By Reference To The Literature 1dtw |
Chain | Residue | Details |
A | PRO536 |
site_id | CSA2 |
Number of Residues | 1 |
Details | Annotated By Reference To The Literature 1dtw |
Chain | Residue | Details |
B | PRO536 |
site_id | CSA3 |
Number of Residues | 1 |
Details | Annotated By Reference To The Literature 1dtw |
Chain | Residue | Details |
C | PRO536 |
site_id | CSA4 |
Number of Residues | 1 |
Details | Annotated By Reference To The Literature 1dtw |
Chain | Residue | Details |
D | PRO536 |
site_id | CSA5 |
Number of Residues | 4 |
Details | Annotated By Reference To The Literature 1dtw |
Chain | Residue | Details |
A | HIS116 | |
A | GLU468 | |
A | HIS115 | |
A | ASP29 |
site_id | CSA6 |
Number of Residues | 4 |
Details | Annotated By Reference To The Literature 1dtw |
Chain | Residue | Details |
B | HIS116 | |
B | GLU468 | |
B | HIS115 | |
B | ASP29 |
site_id | CSA7 |
Number of Residues | 4 |
Details | Annotated By Reference To The Literature 1dtw |
Chain | Residue | Details |
C | HIS116 | |
C | GLU468 | |
C | HIS115 | |
C | ASP29 |
site_id | CSA8 |
Number of Residues | 4 |
Details | Annotated By Reference To The Literature 1dtw |
Chain | Residue | Details |
D | HIS116 | |
D | GLU468 | |
D | HIS115 | |
D | ASP29 |