1OVK

T4 Lysozyme Cavity Mutant L99A/M102Q Bound with N-Allyl-Aniline

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003796	molecular_function	lysozyme activity
A	0003824	molecular_function	catalytic activity
A	0008152	biological_process	metabolic process
A	0009253	biological_process	peptidoglycan catabolic process
A	0016787	molecular_function	hydrolase activity
A	0016798	molecular_function	hydrolase activity, acting on glycosyl bonds
A	0016998	biological_process	cell wall macromolecule catabolic process
A	0030430	cellular_component	host cell cytoplasm
A	0031640	biological_process	killing of cells of another organism
A	0042742	biological_process	defense response to bacterium
A	0044659	biological_process	viral release from host cell by cytolysis

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL A 173

Chain	Residue
A	ASN144
A	ARG145
A	HOH291

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site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CL A 178

Chain	Residue
A	ALA49
A	GLN69
A	SER136
A	ARG137
A	ASN140
A	HOH282

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site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE BME A 168

Chain	Residue
A	ASP72
A	VAL75
A	ARG76
A	LEU79
A	TYR88
A	BME170

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site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE BME A 169

Chain	Residue
A	GLY30
A	PHE104
A	HOH256
A	HOH274

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site_id	AC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE BME A 170

Chain	Residue
A	ASP72
A	BME168
A	HOH199

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site_id	AC6
Number of Residues	9
Details	BINDING SITE FOR RESIDUE NYL A 405

Chain	Residue
A	TYR88
A	ALA99
A	GLN102
A	VAL103
A	VAL111
A	SER117
A	LEU118
A	LEU121
A	PHE153

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Proton donor/acceptor => ECO:0000255|HAMAP-Rule:MF_04110, ECO:0000269|PubMed:3382407, ECO:0000269|PubMed:7831309, ECO:0000269|PubMed:8266098

Chain	Residue	Details
A	GLU11

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site_id	SWS_FT_FI2
Number of Residues	1
Details	ACT_SITE: Proton donor/acceptor => ECO:0000255|HAMAP-Rule:MF_04110, ECO:0000269|PubMed:1892846, ECO:0000269|PubMed:3382407, ECO:0000269|PubMed:7831309, ECO:0000269|PubMed:8266098

Chain	Residue	Details
A	ASP20

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site_id	SWS_FT_FI3
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269|PubMed:8266098

Chain	Residue	Details
A	LEU32
A	PHE104

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	BINDING: BINDING => ECO:0000303|PubMed:7831309

Chain	Residue	Details
A	SER117
A	ASN132

---

Catalytic Information from CSA

site_id	MCSA1
Number of Residues	2
Details	M-CSA 921

Chain	Residue	Details
A	GLU11	proton shuttle (general acid/base)
A	ASP20	covalent catalysis

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