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1OSN

Crystal structure of Varicella zoster virus thymidine kinase in complex with BVDU-MP and ADP

Functional Information from GO Data
ChainGOidnamespacecontents
A0004797molecular_functionthymidine kinase activity
A0005524molecular_functionATP binding
A0006230biological_processTMP biosynthetic process
A0009157biological_processdeoxyribonucleoside monophosphate biosynthetic process
A0016301molecular_functionkinase activity
A0016310biological_processphosphorylation
A0071897biological_processDNA biosynthetic process
B0004797molecular_functionthymidine kinase activity
B0005524molecular_functionATP binding
B0006230biological_processTMP biosynthetic process
B0009157biological_processdeoxyribonucleoside monophosphate biosynthetic process
B0016301molecular_functionkinase activity
B0016310biological_processphosphorylation
B0071897biological_processDNA biosynthetic process
C0004797molecular_functionthymidine kinase activity
C0005524molecular_functionATP binding
C0006230biological_processTMP biosynthetic process
C0009157biological_processdeoxyribonucleoside monophosphate biosynthetic process
C0016301molecular_functionkinase activity
C0016310biological_processphosphorylation
C0071897biological_processDNA biosynthetic process
D0004797molecular_functionthymidine kinase activity
D0005524molecular_functionATP binding
D0006230biological_processTMP biosynthetic process
D0009157biological_processdeoxyribonucleoside monophosphate biosynthetic process
D0016301molecular_functionkinase activity
D0016310biological_processphosphorylation
D0071897biological_processDNA biosynthetic process
Functional Information from PDB Data
site_idAC1
Number of Residues8
DetailsBINDING SITE FOR RESIDUE ADP A 400
ChainResidue
ATYR21
AGLY22
AILE23
AGLY24
ALYS25
ATHR26
ATHR27
ABVP500

site_idAC2
Number of Residues15
DetailsBINDING SITE FOR RESIDUE BVP A 500
ChainResidue
AGLY22
AGLU48
ATRP53
AILE62
ATYR66
AGLN90
APHE93
AHIS97
AARG130
AALA134
ASER135
APHE139
AADP400
AHOH600
ATYR21

site_idAC3
Number of Residues10
DetailsBINDING SITE FOR RESIDUE ADP B 1400
ChainResidue
BTYR21
BGLY22
BILE23
BGLY24
BLYS25
BTHR26
BTHR27
BARG183
BGLN300
BBVP1500

site_idAC4
Number of Residues14
DetailsBINDING SITE FOR RESIDUE BVP B 1500
ChainResidue
BTYR21
BGLY22
BGLU48
BTRP53
BILE62
BTYR66
BGLN90
BPHE93
BHIS97
BARG130
BALA134
BSER135
BPHE139
BADP1400

site_idAC5
Number of Residues10
DetailsBINDING SITE FOR RESIDUE ADP C 2400
ChainResidue
CTYR21
CGLY22
CILE23
CGLY24
CLYS25
CTHR26
CTHR27
CARG183
CGLN300
CBVP2500

site_idAC6
Number of Residues14
DetailsBINDING SITE FOR RESIDUE BVP C 2500
ChainResidue
CTYR21
CGLY22
CGLU48
CTRP53
CILE62
CTYR66
CGLN90
CPHE93
CHIS97
CARG130
CALA134
CSER135
CPHE139
CADP2400

site_idAC7
Number of Residues10
DetailsBINDING SITE FOR RESIDUE ADP D 3400
ChainResidue
DTYR21
DGLY22
DILE23
DGLY24
DLYS25
DTHR26
DTHR27
DARG183
DGLN300
DBVP3500

site_idAC8
Number of Residues14
DetailsBINDING SITE FOR RESIDUE BVP D 3500
ChainResidue
DTYR21
DGLY22
DGLU48
DTRP53
DILE62
DTYR66
DGLN90
DPHE93
DHIS97
DARG130
DALA134
DSER135
DPHE139
DADP3400

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsACT_SITE: Proton acceptor => ECO:0000255|HAMAP-Rule:MF_04029
ChainResidueDetails
AGLU48
BGLU48
CGLU48
DGLU48

site_idSWS_FT_FI2
Number of Residues20
DetailsBINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_04029
ChainResidueDetails
AGLY19
BARG189
CGLY19
CTYR66
CGLN90
CARG183
CARG189
DGLY19
DTYR66
DGLN90
DARG183
ATYR66
DARG189
AGLN90
AARG183
AARG189
BGLY19
BTYR66
BGLN90
BARG183

Catalytic Information from CSA
site_idCSA1
Number of Residues3
DetailsAnnotated By Reference To The Literature 1kim
ChainResidueDetails
AGLY22
AGLU48
AARG130

site_idCSA2
Number of Residues3
DetailsAnnotated By Reference To The Literature 1kim
ChainResidueDetails
BGLY22
BGLU48
BARG130

site_idCSA3
Number of Residues3
DetailsAnnotated By Reference To The Literature 1kim
ChainResidueDetails
CGLY22
CGLU48
CARG130

site_idCSA4
Number of Residues3
DetailsAnnotated By Reference To The Literature 1kim
ChainResidueDetails
DGLY22
DGLU48
DARG130

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PDB entries from 2024-10-30

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