1ORQ

X-ray structure of a voltage-dependent potassium channel in complex with an Fab

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005576	cellular_component	extracellular region
A	0005886	cellular_component	plasma membrane
A	0030183	biological_process	B cell differentiation
C	0005216	molecular_function	monoatomic ion channel activity
C	0006811	biological_process	monoatomic ion transport
C	0016020	cellular_component	membrane
C	0055085	biological_process	transmembrane transport

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	BINDING SITE FOR RESIDUE K C 1

Chain	Residue
C	K2
C	K2
C	K2
C	K2
C	TYR199
C	TYR199
C	TYR199
C	TYR199

---

site_id	AC2
Number of Residues	16
Details	BINDING SITE FOR RESIDUE K C 2

Chain	Residue
C	K1
C	K1
C	K1
C	K3
C	K3
C	K3
C	K3
C	VAL197
C	VAL197
C	VAL197
C	VAL197
C	GLY198
C	GLY198
C	GLY198
C	GLY198
C	K1

---

site_id	AC3
Number of Residues	16
Details	BINDING SITE FOR RESIDUE K C 3

Chain	Residue
C	K2
C	K2
C	K2
C	K2
C	K4
C	K4
C	K4
C	K4
C	THR196
C	THR196
C	THR196
C	THR196
C	VAL197
C	VAL197
C	VAL197
C	VAL197

---

site_id	AC4
Number of Residues	8
Details	BINDING SITE FOR RESIDUE K C 4

Chain	Residue
C	K3
C	K3
C	K3
C	K3
C	THR196
C	THR196
C	THR196
C	THR196

---

site_id	AC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CD C 7

Chain	Residue
C	SER182
C	ASP185

---

site_id	AC6
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CD C 8

Chain	Residue
C	CYS46

---

site_id	AC7
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CD C 9

Chain	Residue
C	PRO95
C	ARG133

---

site_id	AC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CD A 216

Chain	Residue
A	ARG62
A	ARG62
A	GLU82
A	GLU82

---

site_id	AC9
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CD A 217

Chain	Residue
A	ASP168

---

site_id	BC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CD B 220

Chain	Residue
A	ASP152
A	HIS190
B	ASP178

---

site_id	BC2
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CD A 218

Chain	Residue
A	GLU17

---

Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCEATH

Chain	Residue	Details
A	TYR193-HIS199

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	24
Details	TRANSMEM: Helical; Name=Segment S1

Chain	Residue	Details
C	LEU26-LEU50

---

site_id	SWS_FT_FI2
Number of Residues	27
Details	TOPO_DOM: Extracellular => ECO:0000255

Chain	Residue	Details
C	SER51-TYR54
C	GLU93-PRO95
C	GLU172-SER182
C	THR196-ILE208

---

site_id	SWS_FT_FI3
Number of Residues	24
Details	TRANSMEM: Helical; Name=Segment S2

Chain	Residue	Details
C	LEU55-LYS79

---

site_id	SWS_FT_FI4
Number of Residues	18
Details	TOPO_DOM: Cytoplasmic

Chain	Residue	Details
C	SER80-PRO83
C	LEU113-LEU115
C	ARG133-ASP146

---

site_id	SWS_FT_FI5
Number of Residues	8
Details	INTRAMEM: Helical; Name=Segment S3A

Chain	Residue	Details
C	ALA84-TYR92

---

site_id	SWS_FT_FI6
Number of Residues	16
Details	TRANSMEM: Helical; Voltage-sensor; Name=Segment S3B

Chain	Residue	Details
C	ALA96-GLY112

---

site_id	SWS_FT_FI7
Number of Residues	16
Details	TRANSMEM: Helical; Voltage-sensor; Name=Segment S4

Chain	Residue	Details
C	PHE116-SER132

---

site_id	SWS_FT_FI8
Number of Residues	24
Details	TRANSMEM: Helical; Name=Segment S5

Chain	Residue	Details
C	LYS147-VAL171

---

site_id	SWS_FT_FI9
Number of Residues	12
Details	INTRAMEM: Pore-forming => ECO:0000255

Chain	Residue	Details
C	VAL183-THR195

---

site_id	SWS_FT_FI10
Number of Residues	31
Details	TRANSMEM: Helical; Name=Segment S6

Chain	Residue	Details
C	GLY209-VAL240

---