1ORO

A FLEXIBLE LOOP AT THE DIMER INTERFACE IS A PART OF THE ACTIVE SITE OF THE ADJACENT MONOMER OF ESCHERICHIA COLI OROTATE PHOSPHORIBOSYLTRANSFERASE

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000287	molecular_function	magnesium ion binding
A	0004588	molecular_function	orotate phosphoribosyltransferase activity
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
A	0006221	biological_process	pyrimidine nucleotide biosynthetic process
A	0016757	molecular_function	glycosyltransferase activity
A	0042803	molecular_function	protein homodimerization activity
A	0044205	biological_process	'de novo' UMP biosynthetic process
A	0046132	biological_process	pyrimidine ribonucleoside biosynthetic process
A	0055086	biological_process	nucleobase-containing small molecule metabolic process
A	0072528	biological_process	pyrimidine-containing compound biosynthetic process
B	0000287	molecular_function	magnesium ion binding
B	0004588	molecular_function	orotate phosphoribosyltransferase activity
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
B	0006221	biological_process	pyrimidine nucleotide biosynthetic process
B	0016757	molecular_function	glycosyltransferase activity
B	0042803	molecular_function	protein homodimerization activity
B	0044205	biological_process	'de novo' UMP biosynthetic process
B	0046132	biological_process	pyrimidine ribonucleoside biosynthetic process
B	0055086	biological_process	nucleobase-containing small molecule metabolic process
B	0072528	biological_process	pyrimidine-containing compound biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 B 301

Chain	Residue
A	ARG99
A	LYS103
B	ALA71
B	TYR72
B	LYS73
B	LYS100
B	HOH516

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site_id	AC2
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 A 302

Chain	Residue
A	LYS73
A	LYS100
A	HOH502
A	HOH503
A	HOH514
B	ARG99
A	ALA71
A	TYR72

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Functional Information from PROSITE/UniProt

site_id	PS00103
Number of Residues	13
Details	PUR_PYR_PR_TRANSFER Purine/pyrimidine phosphoribosyl transferases signature. VMLVDDVITAGtA

Chain	Residue	Details
A	VAL120-ALA132

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	BINDING: in other chain => ECO:0000255|HAMAP-Rule:MF_01208

Chain	Residue	Details
A	SER27
A	ASP125
B	SER27
B	ASP125

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site_id	SWS_FT_FI2
Number of Residues	8
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_01208

Chain	Residue	Details
A	PHE35
A	GLY106
A	ALA129
A	GLN157
B	PHE35
B	GLY106
B	ALA129
B	GLN157

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site_id	SWS_FT_FI3
Number of Residues	4
Details	BINDING: in other chain => ECO:0000255|HAMAP-Rule:MF_01208, ECO:0000305|PubMed:8620002

Chain	Residue	Details
A	LYS73
A	GLU101
B	LYS73
B	GLU101

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site_id	SWS_FT_FI4
Number of Residues	4
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_01208, ECO:0000305|PubMed:8620002

Chain	Residue	Details
A	LYS100
A	ASP104
B	LYS100
B	ASP104

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Catalytic Information from CSA

site_id	MCSA1
Number of Residues	2
Details	M-CSA 873

Chain	Residue	Details
A	ASP104	electrostatic stabiliser, proton acceptor, proton donor
A	GLY106	electrostatic stabiliser

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site_id	MCSA2
Number of Residues	2
Details	M-CSA 873

Chain	Residue	Details
B	ASP104	electrostatic stabiliser, proton acceptor, proton donor
B	GLY106	electrostatic stabiliser

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