1OR8
Structure of the Predominant protein arginine methyltransferase PRMT1
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005515 | molecular_function | protein binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005654 | cellular_component | nucleoplasm |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005765 | cellular_component | lysosomal membrane |
| A | 0005829 | cellular_component | cytosol |
| A | 0006338 | biological_process | chromatin remodeling |
| A | 0006355 | biological_process | regulation of DNA-templated transcription |
| A | 0006479 | biological_process | protein methylation |
| A | 0008170 | molecular_function | N-methyltransferase activity |
| A | 0008276 | molecular_function | protein methyltransferase activity |
| A | 0008327 | molecular_function | methyl-CpG binding |
| A | 0008380 | biological_process | RNA splicing |
| A | 0008757 | molecular_function | S-adenosylmethionine-dependent methyltransferase activity |
| A | 0016274 | molecular_function | protein-arginine N-methyltransferase activity |
| A | 0018195 | biological_process | peptidyl-arginine modification |
| A | 0018216 | biological_process | peptidyl-arginine methylation |
| A | 0019919 | biological_process | peptidyl-arginine methylation, to asymmetrical-dimethyl arginine |
| A | 0030519 | molecular_function | snoRNP binding |
| A | 0032991 | cellular_component | protein-containing complex |
| A | 0034709 | cellular_component | methylosome |
| A | 0035241 | molecular_function | protein-arginine omega-N monomethyltransferase activity |
| A | 0035242 | molecular_function | protein-arginine omega-N asymmetric methyltransferase activity |
| A | 0035247 | biological_process | peptidyl-arginine omega-N-methylation |
| A | 0042054 | molecular_function | histone methyltransferase activity |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0044020 | molecular_function | histone H4R3 methyltransferase activity |
| A | 0045648 | biological_process | positive regulation of erythrocyte differentiation |
| A | 0045652 | biological_process | regulation of megakaryocyte differentiation |
| A | 0045653 | biological_process | negative regulation of megakaryocyte differentiation |
| A | 0046329 | biological_process | negative regulation of JNK cascade |
| A | 0046500 | biological_process | S-adenosylmethionine metabolic process |
| A | 0046985 | biological_process | positive regulation of hemoglobin biosynthetic process |
| A | 0048738 | biological_process | cardiac muscle tissue development |
| A | 0061431 | biological_process | cellular response to methionine |
| A | 0097421 | biological_process | liver regeneration |
| A | 0106080 | molecular_function | GATOR1 complex binding |
| A | 1900745 | biological_process | positive regulation of p38MAPK cascade |
| A | 1904047 | molecular_function | S-adenosyl-L-methionine binding |
| A | 1904263 | biological_process | positive regulation of TORC1 signaling |
| A | 1905168 | biological_process | positive regulation of double-strand break repair via homologous recombination |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 21 |
| Details | BINDING SITE FOR RESIDUE SAH A 354 |
| Chain | Residue |
| A | HIS45 |
| A | GLY126 |
| A | LYS127 |
| A | VAL128 |
| A | GLU129 |
| A | GLU144 |
| A | MET155 |
| A | HOH355 |
| A | HOH371 |
| A | HOH372 |
| B | ARG9 |
| A | ARG54 |
| C | ARG15 |
| D | ARG3 |
| A | GLY78 |
| A | SER79 |
| A | GLY80 |
| A | ILE83 |
| A | LEU84 |
| A | GLU100 |
| A | CYS101 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE UNL A 582 |
| Chain | Residue |
| A | ASP187 |
| A | TYR190 |
| A | VAL221 |
| A | VAL222 |
| A | ASP223 |
| A | GLN226 |
| A | TYR300 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL A 698 |
| Chain | Residue |
| A | LYS50 |
| A | TRP197 |
| A | ASN200 |
| A | VAL201 |
| A | TYR202 |
| A | HOH573 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL A 699 |
| Chain | Residue |
| A | GLU311 |
| A | GLU312 |
| A | ASP334 |
| A | LYS338 |
| A | HOH403 |
| A | HOH451 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"evidences":[{"source":"PubMed","id":"12737817","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 5 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"12737817","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"Q9JIF0","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"Q9JIF0","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q99873","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"UniProtKB","id":"Q9JIF0","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | a catalytic site defined by CSA, PubMed 12737817 |
| Chain | Residue | Details |
| A | GLU144 | |
| A | GLU153 |
| site_id | MCSA1 |
| Number of Residues | 4 |
| Details | M-CSA 872 |
| Chain | Residue | Details |
| A | ASP51 | proton shuttle (general acid/base) |
| A | GLU144 | electrostatic stabiliser |
| A | GLU153 | electrostatic stabiliser |
| A | HIS293 | proton shuttle (general acid/base) |
