Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004857 | molecular_function | enzyme inhibitor activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0008047 | molecular_function | enzyme activator activity |
| A | 0009401 | biological_process | phosphoenolpyruvate-dependent sugar phosphotransferase system |
| A | 0016775 | molecular_function | phosphotransferase activity, nitrogenous group as acceptor |
| A | 0018106 | biological_process | peptidyl-histidine phosphorylation |
| A | 0030234 | molecular_function | enzyme regulator activity |
| A | 0043609 | biological_process | regulation of carbon utilization |
| A | 0045152 | molecular_function | antisigma factor binding |
| A | 0045819 | biological_process | positive regulation of glycogen catabolic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 A 156 |
| Chain | Residue |
| A | HOH108 |
| A | HIS15 |
| A | THR16 |
| A | ARG17 |
| A | LYS40 |
| A | SER41 |
| A | HOH107 |
| site_id | ACT |
| Number of Residues | 2 |
| Details | THE ACTIVE CENTER IS COMPOSED PRIMARILY OF TWO RESIDUES WHICH ARE CRITICAL IN PHOSPHOTRANSFER, HIS 15 AND ARG 17. |
| site_id | AS6 |
| Number of Residues | 1 |
| Details | IN GRAM-POSITIVE HPR HPRS PHOSPHOTRANSFER ABILITY CAN BE INHIBITED THROUGH PHOSPHORYLATION OF SER 46. WHILE SER 46 IS PRESENT IN GRAM-NEGATIVE HPRS THIS TYPE OF REGULATION IS NOT OF PHYSIOLOGICAL IMPORTANCE AS THE BACTERIA LACKS THE NECESSARY KINASE. IT IS POSSIBLE HOWEVER TO MIMIC THE REGULATORY PHOSPHORYLATION THROUGH THE MUTANT SER46ASP. |
Functional Information from PROSITE/UniProt
| site_id | PS00369 |
| Number of Residues | 8 |
| Details | PTS_HPR_HIS PTS HPR domain histidine phosphorylation site signature. GLHTRPAA |
| Chain | Residue | Details |
| A | GLY13-ALA20 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 84 |
| Details | Domain: {"description":"HPr","evidences":[{"source":"PROSITE-ProRule","id":"PRU00681","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Pros-phosphohistidine intermediate","evidences":[{"source":"PROSITE-ProRule","id":"PRU00681","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"2261470","evidenceCode":"ECO:0000269"}]} |
