1ONI

Crystal structure of a human p14.5, a translational inhibitor reveals different mode of ligand binding near the invariant residues of the Yjgf/UK114 protein family

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003723	molecular_function	RNA binding
A	0003729	molecular_function	mRNA binding
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005759	cellular_component	mitochondrial matrix
A	0005777	cellular_component	peroxisome
A	0005829	cellular_component	cytosol
A	0006402	biological_process	mRNA catabolic process
A	0006629	biological_process	lipid metabolic process
A	0010608	biological_process	post-transcriptional regulation of gene expression
A	0010629	biological_process	negative regulation of gene expression
A	0016787	molecular_function	hydrolase activity
A	0016892	molecular_function	RNA endonuclease activity producing 3'-phosphomonoesters, hydrolytic mechanism
A	0017148	biological_process	negative regulation of translation
A	0019239	molecular_function	deaminase activity
A	0019518	biological_process	L-threonine catabolic process to glycine
A	0061157	biological_process	mRNA destabilization
A	0070062	cellular_component	extracellular exosome
A	0080090	biological_process	regulation of primary metabolic process
A	0120241	molecular_function	2-iminobutanoate/2-iminopropanoate deaminase
A	0120242	molecular_function	2-iminobutanoate deaminase activity
A	0120243	molecular_function	2-iminopropanoate deaminase activity
B	0003723	molecular_function	RNA binding
B	0003729	molecular_function	mRNA binding
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0005739	cellular_component	mitochondrion
B	0005759	cellular_component	mitochondrial matrix
B	0005777	cellular_component	peroxisome
B	0005829	cellular_component	cytosol
B	0006402	biological_process	mRNA catabolic process
B	0006629	biological_process	lipid metabolic process
B	0010608	biological_process	post-transcriptional regulation of gene expression
B	0010629	biological_process	negative regulation of gene expression
B	0016787	molecular_function	hydrolase activity
B	0016892	molecular_function	RNA endonuclease activity producing 3'-phosphomonoesters, hydrolytic mechanism
B	0017148	biological_process	negative regulation of translation
B	0019239	molecular_function	deaminase activity
B	0019518	biological_process	L-threonine catabolic process to glycine
B	0061157	biological_process	mRNA destabilization
B	0070062	cellular_component	extracellular exosome
B	0080090	biological_process	regulation of primary metabolic process
B	0120241	molecular_function	2-iminobutanoate/2-iminopropanoate deaminase
B	0120242	molecular_function	2-iminobutanoate deaminase activity
B	0120243	molecular_function	2-iminopropanoate deaminase activity
C	0003723	molecular_function	RNA binding
C	0003729	molecular_function	mRNA binding
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0005739	cellular_component	mitochondrion
C	0005759	cellular_component	mitochondrial matrix
C	0005777	cellular_component	peroxisome
C	0005829	cellular_component	cytosol
C	0006402	biological_process	mRNA catabolic process
C	0006629	biological_process	lipid metabolic process
C	0010608	biological_process	post-transcriptional regulation of gene expression
C	0010629	biological_process	negative regulation of gene expression
C	0016787	molecular_function	hydrolase activity
C	0016892	molecular_function	RNA endonuclease activity producing 3'-phosphomonoesters, hydrolytic mechanism
C	0017148	biological_process	negative regulation of translation
C	0019239	molecular_function	deaminase activity
C	0019518	biological_process	L-threonine catabolic process to glycine
C	0061157	biological_process	mRNA destabilization
C	0070062	cellular_component	extracellular exosome
C	0080090	biological_process	regulation of primary metabolic process
C	0120241	molecular_function	2-iminobutanoate/2-iminopropanoate deaminase
C	0120242	molecular_function	2-iminobutanoate deaminase activity
C	0120243	molecular_function	2-iminopropanoate deaminase activity
D	0003723	molecular_function	RNA binding
D	0003729	molecular_function	mRNA binding
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005737	cellular_component	cytoplasm
D	0005739	cellular_component	mitochondrion
D	0005759	cellular_component	mitochondrial matrix
D	0005777	cellular_component	peroxisome
D	0005829	cellular_component	cytosol
D	0006402	biological_process	mRNA catabolic process
D	0006629	biological_process	lipid metabolic process
D	0010608	biological_process	post-transcriptional regulation of gene expression
D	0010629	biological_process	negative regulation of gene expression
D	0016787	molecular_function	hydrolase activity
D	0016892	molecular_function	RNA endonuclease activity producing 3'-phosphomonoesters, hydrolytic mechanism
D	0017148	biological_process	negative regulation of translation
D	0019239	molecular_function	deaminase activity
D	0019518	biological_process	L-threonine catabolic process to glycine
D	0061157	biological_process	mRNA destabilization
D	0070062	cellular_component	extracellular exosome
D	0080090	biological_process	regulation of primary metabolic process
D	0120241	molecular_function	2-iminobutanoate/2-iminopropanoate deaminase
D	0120242	molecular_function	2-iminobutanoate deaminase activity
D	0120243	molecular_function	2-iminopropanoate deaminase activity
E	0003723	molecular_function	RNA binding
E	0003729	molecular_function	mRNA binding
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005737	cellular_component	cytoplasm
E	0005739	cellular_component	mitochondrion
E	0005759	cellular_component	mitochondrial matrix
E	0005777	cellular_component	peroxisome
E	0005829	cellular_component	cytosol
E	0006402	biological_process	mRNA catabolic process
E	0006629	biological_process	lipid metabolic process
E	0010608	biological_process	post-transcriptional regulation of gene expression
E	0010629	biological_process	negative regulation of gene expression
E	0016787	molecular_function	hydrolase activity
E	0016892	molecular_function	RNA endonuclease activity producing 3'-phosphomonoesters, hydrolytic mechanism
E	0017148	biological_process	negative regulation of translation
E	0019239	molecular_function	deaminase activity
E	0019518	biological_process	L-threonine catabolic process to glycine
E	0061157	biological_process	mRNA destabilization
E	0070062	cellular_component	extracellular exosome
E	0080090	biological_process	regulation of primary metabolic process
E	0120241	molecular_function	2-iminobutanoate/2-iminopropanoate deaminase
E	0120242	molecular_function	2-iminobutanoate deaminase activity
E	0120243	molecular_function	2-iminopropanoate deaminase activity
F	0003723	molecular_function	RNA binding
F	0003729	molecular_function	mRNA binding
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005737	cellular_component	cytoplasm
F	0005739	cellular_component	mitochondrion
F	0005759	cellular_component	mitochondrial matrix
F	0005777	cellular_component	peroxisome
F	0005829	cellular_component	cytosol
F	0006402	biological_process	mRNA catabolic process
F	0006629	biological_process	lipid metabolic process
F	0010608	biological_process	post-transcriptional regulation of gene expression
F	0010629	biological_process	negative regulation of gene expression
F	0016787	molecular_function	hydrolase activity
F	0016892	molecular_function	RNA endonuclease activity producing 3'-phosphomonoesters, hydrolytic mechanism
F	0017148	biological_process	negative regulation of translation
F	0019239	molecular_function	deaminase activity
F	0019518	biological_process	L-threonine catabolic process to glycine
F	0061157	biological_process	mRNA destabilization
F	0070062	cellular_component	extracellular exosome
F	0080090	biological_process	regulation of primary metabolic process
F	0120241	molecular_function	2-iminobutanoate/2-iminopropanoate deaminase
F	0120242	molecular_function	2-iminobutanoate deaminase activity
F	0120243	molecular_function	2-iminopropanoate deaminase activity
G	0003723	molecular_function	RNA binding
G	0003729	molecular_function	mRNA binding
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0005737	cellular_component	cytoplasm
G	0005739	cellular_component	mitochondrion
G	0005759	cellular_component	mitochondrial matrix
G	0005777	cellular_component	peroxisome
G	0005829	cellular_component	cytosol
G	0006402	biological_process	mRNA catabolic process
G	0006629	biological_process	lipid metabolic process
G	0010608	biological_process	post-transcriptional regulation of gene expression
G	0010629	biological_process	negative regulation of gene expression
G	0016787	molecular_function	hydrolase activity
G	0016892	molecular_function	RNA endonuclease activity producing 3'-phosphomonoesters, hydrolytic mechanism
G	0017148	biological_process	negative regulation of translation
G	0019239	molecular_function	deaminase activity
G	0019518	biological_process	L-threonine catabolic process to glycine
G	0061157	biological_process	mRNA destabilization
G	0070062	cellular_component	extracellular exosome
G	0080090	biological_process	regulation of primary metabolic process
G	0120241	molecular_function	2-iminobutanoate/2-iminopropanoate deaminase
G	0120242	molecular_function	2-iminobutanoate deaminase activity
G	0120243	molecular_function	2-iminopropanoate deaminase activity
H	0003723	molecular_function	RNA binding
H	0003729	molecular_function	mRNA binding
H	0005515	molecular_function	protein binding
H	0005634	cellular_component	nucleus
H	0005737	cellular_component	cytoplasm
H	0005739	cellular_component	mitochondrion
H	0005759	cellular_component	mitochondrial matrix
H	0005777	cellular_component	peroxisome
H	0005829	cellular_component	cytosol
H	0006402	biological_process	mRNA catabolic process
H	0006629	biological_process	lipid metabolic process
H	0010608	biological_process	post-transcriptional regulation of gene expression
H	0010629	biological_process	negative regulation of gene expression
H	0016787	molecular_function	hydrolase activity
H	0016892	molecular_function	RNA endonuclease activity producing 3'-phosphomonoesters, hydrolytic mechanism
H	0017148	biological_process	negative regulation of translation
H	0019239	molecular_function	deaminase activity
H	0019518	biological_process	L-threonine catabolic process to glycine
H	0061157	biological_process	mRNA destabilization
H	0070062	cellular_component	extracellular exosome
H	0080090	biological_process	regulation of primary metabolic process
H	0120241	molecular_function	2-iminobutanoate/2-iminopropanoate deaminase
H	0120242	molecular_function	2-iminobutanoate deaminase activity
H	0120243	molecular_function	2-iminopropanoate deaminase activity
I	0003723	molecular_function	RNA binding
I	0003729	molecular_function	mRNA binding
I	0005515	molecular_function	protein binding
I	0005634	cellular_component	nucleus
I	0005737	cellular_component	cytoplasm
I	0005739	cellular_component	mitochondrion
I	0005759	cellular_component	mitochondrial matrix
I	0005777	cellular_component	peroxisome
I	0005829	cellular_component	cytosol
I	0006402	biological_process	mRNA catabolic process
I	0006629	biological_process	lipid metabolic process
I	0010608	biological_process	post-transcriptional regulation of gene expression
I	0010629	biological_process	negative regulation of gene expression
I	0016787	molecular_function	hydrolase activity
I	0016892	molecular_function	RNA endonuclease activity producing 3'-phosphomonoesters, hydrolytic mechanism
I	0017148	biological_process	negative regulation of translation
I	0019239	molecular_function	deaminase activity
I	0019518	biological_process	L-threonine catabolic process to glycine
I	0061157	biological_process	mRNA destabilization
I	0070062	cellular_component	extracellular exosome
I	0080090	biological_process	regulation of primary metabolic process
I	0120241	molecular_function	2-iminobutanoate/2-iminopropanoate deaminase
I	0120242	molecular_function	2-iminobutanoate deaminase activity
I	0120243	molecular_function	2-iminopropanoate deaminase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	BINDING SITE FOR RESIDUE BEZ A 501

Chain	Residue
A	PHE89
A	ARG107
A	ALA109
A	BEZ502
A	HOH525
B	TYR21
B	GLY35
B	GLU122

---

site_id	AC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE BEZ A 502

Chain	Residue
A	ASN90
A	ASN93
A	ARG107
A	BEZ501
B	ILE18
B	GLY19
A	PHE89

---

site_id	AC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE BEZ B 503

Chain	Residue
B	ARG107
B	ALA109
B	BEZ504
B	HOH546
B	HOH560
C	TYR21
C	GLY35

---

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE BEZ B 504

Chain	Residue
B	ILE86
B	PHE89
B	BEZ503
B	HOH508
C	PRO116
C	LYS117

---

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE BEZ C 505

Chain	Residue
A	TYR21
A	GLY35
C	PHE89
C	ARG107

---

site_id	AC6
Number of Residues	8
Details	BINDING SITE FOR RESIDUE BEZ D 507

Chain	Residue
D	PHE89
D	ARG107
D	ALA109
D	BEZ508
F	ILE18
F	TYR21
F	GLY35
F	GLU122

---

site_id	AC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE BEZ D 508

Chain	Residue
D	PHE89
D	ASN90
D	ASN93
D	ARG107
D	BEZ507
F	GLY19

---

site_id	AC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE BEZ E 509

Chain	Residue
D	TYR21
D	GLY35
E	PHE89
E	ARG107
E	HOH525
E	HOH542

---

site_id	AC9
Number of Residues	8
Details	BINDING SITE FOR RESIDUE BEZ F 511

Chain	Residue
E	TYR21
E	GLY35
E	GLU122
F	PHE89
F	ARG107
F	ALA109
F	HOH538
F	HOH565

---

site_id	BC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE BEZ G 513

Chain	Residue
G	PHE89
G	ARG107
G	HOH522
H	GLY35

---

site_id	BC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE BEZ H 515

Chain	Residue
H	PHE89
H	ARG107
I	GLY35
I	ILE37
I	HOH545

---

site_id	BC3
Number of Residues	8
Details	BINDING SITE FOR RESIDUE BEZ I 517

Chain	Residue
G	TYR21
G	GLY35
G	GLU122
I	PHE89
I	ARG107
I	ALA109
I	BEZ518
I	HOH540

---

site_id	BC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE BEZ I 518

Chain	Residue
G	ILE18
G	GLY19
I	PHE89
I	ASN90
I	ASN93
I	ARG107
I	BEZ517

---

Functional Information from PROSITE/UniProt

site_id	PS01094
Number of Residues	19
Details	UPF0076 Uncharacterized protein family UPF0076 signature. PARAaYqvAaLpkgsr...IEI

Chain	Residue	Details
A	PRO105-ILE123

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	9
Details	Modified residue: {"description":"N-acetylserine","evidences":[{"source":"PubMed","id":"25944712","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	27
Details	Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"P52760","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	9
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	3
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---