Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004362 | molecular_function | glutathione-disulfide reductase (NADPH) activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0005829 | cellular_component | cytosol |
| A | 0006749 | biological_process | glutathione metabolic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016668 | molecular_function | oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor |
| A | 0034599 | biological_process | cellular response to oxidative stress |
| A | 0045454 | biological_process | cell redox homeostasis |
| A | 0050660 | molecular_function | flavin adenine dinucleotide binding |
| A | 0098869 | biological_process | cellular oxidant detoxification |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 30 |
| Details | BINDING SITE FOR RESIDUE FAD A 500 |
| Chain | Residue |
| A | GLY8 |
| A | VAL42 |
| A | GLY43 |
| A | CYS44 |
| A | LYS47 |
| A | GLY108 |
| A | THR109 |
| A | ALA110 |
| A | ALA147 |
| A | VAL148 |
| A | GLY149 |
| A | GLY9 |
| A | SER166 |
| A | TYR185 |
| A | ARG272 |
| A | ASP275 |
| A | GLY310 |
| A | ASP311 |
| A | GLN351 |
| A | LEU352 |
| A | THR353 |
| A | PRO354 |
| A | GLY10 |
| A | HIS484 |
| A | SER11 |
| A | GLY12 |
| A | GLU31 |
| A | LYS32 |
| A | THR38 |
| A | CYS39 |
Functional Information from PROSITE/UniProt
| site_id | PS00076 |
| Number of Residues | 11 |
| Details | PYRIDINE_REDOX_1 Pyridine nucleotide-disulphide oxidoreductases class-I active site. GGtCVnvGCVP |
| Chain | Residue | Details |
| A | GLY36-PRO46 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"UniProtKB","id":"P00390","evidenceCode":"ECO:0000250"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 10 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"P00390","evidenceCode":"ECO:0000250"}]} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 9 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"12729762","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1ONF","evidenceCode":"ECO:0007744"}]} |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1get |
| Chain | Residue | Details |
| A | GLU489 | |
| A | HIS484 | |
| site_id | CSA2 |
| Number of Residues | 5 |
| Details | Annotated By Reference To The Literature 1get |
| Chain | Residue | Details |
| A | CYS44 | |
| A | LYS47 | |
| A | TYR185 | |
| A | GLU189 | |
| A | CYS39 | |
