Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

1ON3

Transcarboxylase 12S crystal structure: hexamer assembly and substrate binding to a multienzyme core (with methylmalonyl-coenzyme a and methylmalonic acid bound)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003989	molecular_function	acetyl-CoA carboxylase activity
A	0004658	molecular_function	propionyl-CoA carboxylase activity
A	0006633	biological_process	fatty acid biosynthetic process
A	0009317	cellular_component	acetyl-CoA carboxylase complex
A	0016740	molecular_function	transferase activity
A	0016874	molecular_function	ligase activity
A	0047154	molecular_function	methylmalonyl-CoA carboxytransferase activity
B	0003989	molecular_function	acetyl-CoA carboxylase activity
B	0004658	molecular_function	propionyl-CoA carboxylase activity
B	0006633	biological_process	fatty acid biosynthetic process
B	0009317	cellular_component	acetyl-CoA carboxylase complex
B	0016740	molecular_function	transferase activity
B	0016874	molecular_function	ligase activity
B	0047154	molecular_function	methylmalonyl-CoA carboxytransferase activity
C	0003989	molecular_function	acetyl-CoA carboxylase activity
C	0004658	molecular_function	propionyl-CoA carboxylase activity
C	0006633	biological_process	fatty acid biosynthetic process
C	0009317	cellular_component	acetyl-CoA carboxylase complex
C	0016740	molecular_function	transferase activity
C	0016874	molecular_function	ligase activity
C	0047154	molecular_function	methylmalonyl-CoA carboxytransferase activity
D	0003989	molecular_function	acetyl-CoA carboxylase activity
D	0004658	molecular_function	propionyl-CoA carboxylase activity
D	0006633	biological_process	fatty acid biosynthetic process
D	0009317	cellular_component	acetyl-CoA carboxylase complex
D	0016740	molecular_function	transferase activity
D	0016874	molecular_function	ligase activity
D	0047154	molecular_function	methylmalonyl-CoA carboxytransferase activity
E	0003989	molecular_function	acetyl-CoA carboxylase activity
E	0004658	molecular_function	propionyl-CoA carboxylase activity
E	0006633	biological_process	fatty acid biosynthetic process
E	0009317	cellular_component	acetyl-CoA carboxylase complex
E	0016740	molecular_function	transferase activity
E	0016874	molecular_function	ligase activity
E	0047154	molecular_function	methylmalonyl-CoA carboxytransferase activity
F	0003989	molecular_function	acetyl-CoA carboxylase activity
F	0004658	molecular_function	propionyl-CoA carboxylase activity
F	0006633	biological_process	fatty acid biosynthetic process
F	0009317	cellular_component	acetyl-CoA carboxylase complex
F	0016740	molecular_function	transferase activity
F	0016874	molecular_function	ligase activity
F	0047154	molecular_function	methylmalonyl-CoA carboxytransferase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CD A 7001

Chain	Residue
A	HIS388
A	HOH7239
A	HOH7241
D	HIS388
D	HOH5213
D	HOH5227

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CD B 7002

Chain	Residue
E	HOH5189
E	HOH5233
E	HOH5284
B	HIS388
B	HOH7255
E	HIS388

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CD C 7003

Chain	Residue
C	HIS388
C	HOH7255
C	HOH7258
F	HIS388
F	HOH6234
F	HOH6235

site_id	AC4
Number of Residues	25
Details	BINDING SITE FOR RESIDUE MCA A 4001

Chain	Residue
A	ARG35
A	PHE105
A	MET108
A	GLY109
A	SER111
A	GLY141
A	ALA143
A	ARG144
A	ILE145
A	GLN146
A	GLY181
A	GLY182
A	DXX5001
A	HOH7037
A	HOH7174
A	HOH7179
A	HOH7182
A	HOH7326
A	HOH7358
A	HOH7437
A	HOH7442
A	HOH7524
D	GLY413
D	GLY414
D	VAL439

site_id	AC5
Number of Residues	29
Details	BINDING SITE FOR RESIDUE MCA B 4002

Chain	Residue
B	ARG35
B	PHE105
B	MET108
B	GLY109
B	SER111
B	GLY141
B	GLY142
B	ALA143
B	ARG144
B	ILE145
B	GLN146
B	GLY181
B	GLY182
B	DXX5002
B	HOH7014
B	HOH7040
B	HOH7064
B	HOH7243
B	HOH7248
B	HOH7346
B	HOH7383
B	HOH7423
B	HOH7425
B	HOH7442
B	HOH7520
B	HOH7524
E	GLY413
E	GLY414
E	VAL439

site_id	AC6
Number of Residues	29
Details	BINDING SITE FOR RESIDUE MCA C 4003

Chain	Residue
F	VAL448
F	ARG451
C	ARG35
C	PHE105
C	MET108
C	GLY109
C	SER111
C	GLY141
C	ALA143
C	ARG144
C	ILE145
C	GLN146
C	GLY181
C	GLY182
C	DXX5003
C	HOH7036
C	HOH7067
C	HOH7091
C	HOH7203
C	HOH7227
C	HOH7236
C	HOH7312
C	HOH7313
C	HOH7383
C	HOH7445
C	HOH7556
F	GLY413
F	GLY414
F	VAL439

site_id	AC7
Number of Residues	30
Details	BINDING SITE FOR RESIDUE MCA D 4004

Chain	Residue
A	GLY413
A	GLY414
A	VAL439
A	MET440
A	LYS452
D	ARG35
D	PHE105
D	MET108
D	GLY109
D	SER111
D	GLY141
D	GLY142
D	ALA143
D	ARG144
D	ILE145
D	GLN146
D	PRO178
D	GLY181
D	GLY182
D	HOH5078
D	HOH5080
D	HOH5166
D	HOH5195
D	HOH5228
D	HOH5252
D	HOH5335
D	HOH5354
D	HOH5423
D	HOH5481
D	HOH5507

site_id	AC8
Number of Residues	26
Details	BINDING SITE FOR RESIDUE MCA E 4005

Chain	Residue
B	GLY413
B	GLY414
B	VAL439
B	ARG451
E	ARG35
E	PHE105
E	MET108
E	GLY109
E	SER111
E	GLY141
E	ALA143
E	ARG144
E	ILE145
E	GLN146
E	GLY181
E	GLY182
E	DXX5005
E	HOH5020
E	HOH5053
E	HOH5055
E	HOH5094
E	HOH5113
E	HOH5193
E	HOH5484
E	HOH5514
E	HOH5541

site_id	AC9
Number of Residues	28
Details	BINDING SITE FOR RESIDUE MCA F 4006

Chain	Residue
C	GLY413
C	GLY414
C	VAL439
C	ARG451
C	HOH7347
C	HOH7497
F	ARG35
F	PHE105
F	MET108
F	GLY109
F	SER111
F	GLY141
F	ALA143
F	ARG144
F	ILE145
F	GLN146
F	GLY181
F	GLY182
F	HOH6038
F	HOH6082
F	HOH6094
F	HOH6115
F	HOH6181
F	HOH6247
F	HOH6405
F	HOH6409
F	HOH6424
F	HOH6442

site_id	BC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE DXX A 5001

Chain	Residue
A	GLY205
A	VAL208
A	MCA4001
A	HOH7421
D	MET440
D	HOH5504

site_id	BC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DXX B 5002

Chain	Residue
B	GLY205
B	VAL208
B	MCA4002
B	HOH7360

site_id	BC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DXX C 5003

Chain	Residue
C	GLY205
C	VAL208
C	MCA4003
C	HOH7333
F	HOH6469

site_id	BC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DXX D 5004

Chain	Residue
D	GLY205
D	VAL208
D	HOH5252
D	HOH5285
D	HOH5300

site_id	BC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE DXX E 5005

Chain	Residue
E	ILE203
E	GLY205
E	VAL208
E	MCA4005
E	HOH5055
E	HOH5488

site_id	BC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DXX F 5006

Chain	Residue
C	MET440
F	THR204
F	GLY205
F	VAL208
F	HOH6523

site_id	BC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MPD A 6001

Chain	Residue
A	LYS251
A	ASN268
A	TRP303
A	ASP305
A	HOH7122
A	HOH7254

site_id	BC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MPD B 6002

Chain	Residue
B	LYS251
B	ASN268
B	ASP305
B	HOH7293
B	HOH7294
B	HOH7411

site_id	BC9
Number of Residues	7
Details	BINDING SITE FOR RESIDUE MPD F 6006

Chain	Residue
F	LYS251
F	ASN268
F	TRP303
F	ASP305
F	HOH6246
F	HOH6268
F	HOH6461

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1530
Details	Domain: {"description":"CoA carboxyltransferase N-terminal","evidences":[{"source":"PROSITE-ProRule","id":"PRU01136","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	928
Details	Domain: {"description":"CoA carboxyltransferase C-terminal","evidences":[{"source":"PROSITE-ProRule","id":"PRU01137","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	1972
Details	Region: {"description":"Carboxyltransferase","evidences":[{"source":"PROSITE-ProRule","id":"PRU01138","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

Catalytic Information from CSA

site_id	CSA1
Number of Residues	4
Details	Annotated By Reference To The Literature 1xny

Chain	Residue	Details
A	SER415
A	GLY414
D	GLY181
D	GLY182

site_id	CSA2
Number of Residues	4
Details	Annotated By Reference To The Literature 1xny

Chain	Residue	Details
E	GLY181
E	GLY182
B	SER415
B	GLY414

site_id	CSA3
Number of Residues	4
Details	Annotated By Reference To The Literature 1xny

Chain	Residue	Details
F	GLY181
F	GLY182
C	SER415
C	GLY414

site_id	CSA4
Number of Residues	4
Details	Annotated By Reference To The Literature 1xny

Chain	Residue	Details
A	GLY181
A	GLY182
D	SER415
D	GLY414

site_id	CSA5
Number of Residues	4
Details	Annotated By Reference To The Literature 1xny

Chain	Residue	Details
E	SER415
E	GLY414
B	GLY181
B	GLY182

site_id	CSA6
Number of Residues	4
Details	Annotated By Reference To The Literature 1xny

Chain	Residue	Details
F	SER415
F	GLY414
C	GLY181
C	GLY182

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)