1ON3
Transcarboxylase 12S crystal structure: hexamer assembly and substrate binding to a multienzyme core (with methylmalonyl-coenzyme a and methylmalonic acid bound)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003989 | molecular_function | acetyl-CoA carboxylase activity |
| A | 0006633 | biological_process | fatty acid biosynthetic process |
| A | 0009317 | cellular_component | acetyl-CoA carboxylase complex |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016874 | molecular_function | ligase activity |
| A | 0047154 | molecular_function | methylmalonyl-CoA carboxytransferase activity |
| B | 0003989 | molecular_function | acetyl-CoA carboxylase activity |
| B | 0006633 | biological_process | fatty acid biosynthetic process |
| B | 0009317 | cellular_component | acetyl-CoA carboxylase complex |
| B | 0016740 | molecular_function | transferase activity |
| B | 0016874 | molecular_function | ligase activity |
| B | 0047154 | molecular_function | methylmalonyl-CoA carboxytransferase activity |
| C | 0003989 | molecular_function | acetyl-CoA carboxylase activity |
| C | 0006633 | biological_process | fatty acid biosynthetic process |
| C | 0009317 | cellular_component | acetyl-CoA carboxylase complex |
| C | 0016740 | molecular_function | transferase activity |
| C | 0016874 | molecular_function | ligase activity |
| C | 0047154 | molecular_function | methylmalonyl-CoA carboxytransferase activity |
| D | 0003989 | molecular_function | acetyl-CoA carboxylase activity |
| D | 0006633 | biological_process | fatty acid biosynthetic process |
| D | 0009317 | cellular_component | acetyl-CoA carboxylase complex |
| D | 0016740 | molecular_function | transferase activity |
| D | 0016874 | molecular_function | ligase activity |
| D | 0047154 | molecular_function | methylmalonyl-CoA carboxytransferase activity |
| E | 0003989 | molecular_function | acetyl-CoA carboxylase activity |
| E | 0006633 | biological_process | fatty acid biosynthetic process |
| E | 0009317 | cellular_component | acetyl-CoA carboxylase complex |
| E | 0016740 | molecular_function | transferase activity |
| E | 0016874 | molecular_function | ligase activity |
| E | 0047154 | molecular_function | methylmalonyl-CoA carboxytransferase activity |
| F | 0003989 | molecular_function | acetyl-CoA carboxylase activity |
| F | 0006633 | biological_process | fatty acid biosynthetic process |
| F | 0009317 | cellular_component | acetyl-CoA carboxylase complex |
| F | 0016740 | molecular_function | transferase activity |
| F | 0016874 | molecular_function | ligase activity |
| F | 0047154 | molecular_function | methylmalonyl-CoA carboxytransferase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CD A 7001 |
| Chain | Residue |
| A | HIS388 |
| A | HOH7239 |
| A | HOH7241 |
| D | HIS388 |
| D | HOH5213 |
| D | HOH5227 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CD B 7002 |
| Chain | Residue |
| E | HOH5189 |
| E | HOH5233 |
| E | HOH5284 |
| B | HIS388 |
| B | HOH7255 |
| E | HIS388 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CD C 7003 |
| Chain | Residue |
| C | HIS388 |
| C | HOH7255 |
| C | HOH7258 |
| F | HIS388 |
| F | HOH6234 |
| F | HOH6235 |
| site_id | AC4 |
| Number of Residues | 25 |
| Details | BINDING SITE FOR RESIDUE MCA A 4001 |
| Chain | Residue |
| A | ARG35 |
| A | PHE105 |
| A | MET108 |
| A | GLY109 |
| A | SER111 |
| A | GLY141 |
| A | ALA143 |
| A | ARG144 |
| A | ILE145 |
| A | GLN146 |
| A | GLY181 |
| A | GLY182 |
| A | DXX5001 |
| A | HOH7037 |
| A | HOH7174 |
| A | HOH7179 |
| A | HOH7182 |
| A | HOH7326 |
| A | HOH7358 |
| A | HOH7437 |
| A | HOH7442 |
| A | HOH7524 |
| D | GLY413 |
| D | GLY414 |
| D | VAL439 |
| site_id | AC5 |
| Number of Residues | 29 |
| Details | BINDING SITE FOR RESIDUE MCA B 4002 |
| Chain | Residue |
| B | ARG35 |
| B | PHE105 |
| B | MET108 |
| B | GLY109 |
| B | SER111 |
| B | GLY141 |
| B | GLY142 |
| B | ALA143 |
| B | ARG144 |
| B | ILE145 |
| B | GLN146 |
| B | GLY181 |
| B | GLY182 |
| B | DXX5002 |
| B | HOH7014 |
| B | HOH7040 |
| B | HOH7064 |
| B | HOH7243 |
| B | HOH7248 |
| B | HOH7346 |
| B | HOH7383 |
| B | HOH7423 |
| B | HOH7425 |
| B | HOH7442 |
| B | HOH7520 |
| B | HOH7524 |
| E | GLY413 |
| E | GLY414 |
| E | VAL439 |
| site_id | AC6 |
| Number of Residues | 29 |
| Details | BINDING SITE FOR RESIDUE MCA C 4003 |
| Chain | Residue |
| F | VAL448 |
| F | ARG451 |
| C | ARG35 |
| C | PHE105 |
| C | MET108 |
| C | GLY109 |
| C | SER111 |
| C | GLY141 |
| C | ALA143 |
| C | ARG144 |
| C | ILE145 |
| C | GLN146 |
| C | GLY181 |
| C | GLY182 |
| C | DXX5003 |
| C | HOH7036 |
| C | HOH7067 |
| C | HOH7091 |
| C | HOH7203 |
| C | HOH7227 |
| C | HOH7236 |
| C | HOH7312 |
| C | HOH7313 |
| C | HOH7383 |
| C | HOH7445 |
| C | HOH7556 |
| F | GLY413 |
| F | GLY414 |
| F | VAL439 |
| site_id | AC7 |
| Number of Residues | 30 |
| Details | BINDING SITE FOR RESIDUE MCA D 4004 |
| Chain | Residue |
| A | GLY413 |
| A | GLY414 |
| A | VAL439 |
| A | MET440 |
| A | LYS452 |
| D | ARG35 |
| D | PHE105 |
| D | MET108 |
| D | GLY109 |
| D | SER111 |
| D | GLY141 |
| D | GLY142 |
| D | ALA143 |
| D | ARG144 |
| D | ILE145 |
| D | GLN146 |
| D | PRO178 |
| D | GLY181 |
| D | GLY182 |
| D | HOH5078 |
| D | HOH5080 |
| D | HOH5166 |
| D | HOH5195 |
| D | HOH5228 |
| D | HOH5252 |
| D | HOH5335 |
| D | HOH5354 |
| D | HOH5423 |
| D | HOH5481 |
| D | HOH5507 |
| site_id | AC8 |
| Number of Residues | 26 |
| Details | BINDING SITE FOR RESIDUE MCA E 4005 |
| Chain | Residue |
| B | GLY413 |
| B | GLY414 |
| B | VAL439 |
| B | ARG451 |
| E | ARG35 |
| E | PHE105 |
| E | MET108 |
| E | GLY109 |
| E | SER111 |
| E | GLY141 |
| E | ALA143 |
| E | ARG144 |
| E | ILE145 |
| E | GLN146 |
| E | GLY181 |
| E | GLY182 |
| E | DXX5005 |
| E | HOH5020 |
| E | HOH5053 |
| E | HOH5055 |
| E | HOH5094 |
| E | HOH5113 |
| E | HOH5193 |
| E | HOH5484 |
| E | HOH5514 |
| E | HOH5541 |
| site_id | AC9 |
| Number of Residues | 28 |
| Details | BINDING SITE FOR RESIDUE MCA F 4006 |
| Chain | Residue |
| C | GLY413 |
| C | GLY414 |
| C | VAL439 |
| C | ARG451 |
| C | HOH7347 |
| C | HOH7497 |
| F | ARG35 |
| F | PHE105 |
| F | MET108 |
| F | GLY109 |
| F | SER111 |
| F | GLY141 |
| F | ALA143 |
| F | ARG144 |
| F | ILE145 |
| F | GLN146 |
| F | GLY181 |
| F | GLY182 |
| F | HOH6038 |
| F | HOH6082 |
| F | HOH6094 |
| F | HOH6115 |
| F | HOH6181 |
| F | HOH6247 |
| F | HOH6405 |
| F | HOH6409 |
| F | HOH6424 |
| F | HOH6442 |
| site_id | BC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE DXX A 5001 |
| Chain | Residue |
| A | GLY205 |
| A | VAL208 |
| A | MCA4001 |
| A | HOH7421 |
| D | MET440 |
| D | HOH5504 |
| site_id | BC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE DXX B 5002 |
| Chain | Residue |
| B | GLY205 |
| B | VAL208 |
| B | MCA4002 |
| B | HOH7360 |
| site_id | BC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE DXX C 5003 |
| Chain | Residue |
| C | GLY205 |
| C | VAL208 |
| C | MCA4003 |
| C | HOH7333 |
| F | HOH6469 |
| site_id | BC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE DXX D 5004 |
| Chain | Residue |
| D | GLY205 |
| D | VAL208 |
| D | HOH5252 |
| D | HOH5285 |
| D | HOH5300 |
| site_id | BC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE DXX E 5005 |
| Chain | Residue |
| E | ILE203 |
| E | GLY205 |
| E | VAL208 |
| E | MCA4005 |
| E | HOH5055 |
| E | HOH5488 |
| site_id | BC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE DXX F 5006 |
| Chain | Residue |
| C | MET440 |
| F | THR204 |
| F | GLY205 |
| F | VAL208 |
| F | HOH6523 |
| site_id | BC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MPD A 6001 |
| Chain | Residue |
| A | LYS251 |
| A | ASN268 |
| A | TRP303 |
| A | ASP305 |
| A | HOH7122 |
| A | HOH7254 |
| site_id | BC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MPD B 6002 |
| Chain | Residue |
| B | LYS251 |
| B | ASN268 |
| B | ASP305 |
| B | HOH7293 |
| B | HOH7294 |
| B | HOH7411 |
| site_id | BC9 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE MPD F 6006 |
| Chain | Residue |
| F | LYS251 |
| F | ASN268 |
| F | TRP303 |
| F | ASP305 |
| F | HOH6246 |
| F | HOH6268 |
| F | HOH6461 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1xny |
| Chain | Residue | Details |
| A | SER415 | |
| A | GLY414 | |
| D | GLY181 | |
| D | GLY182 |
| site_id | CSA2 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1xny |
| Chain | Residue | Details |
| E | GLY181 | |
| E | GLY182 | |
| B | SER415 | |
| B | GLY414 |
| site_id | CSA3 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1xny |
| Chain | Residue | Details |
| F | GLY181 | |
| F | GLY182 | |
| C | SER415 | |
| C | GLY414 |
| site_id | CSA4 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1xny |
| Chain | Residue | Details |
| A | GLY181 | |
| A | GLY182 | |
| D | SER415 | |
| D | GLY414 |
| site_id | CSA5 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1xny |
| Chain | Residue | Details |
| E | SER415 | |
| E | GLY414 | |
| B | GLY181 | |
| B | GLY182 |
| site_id | CSA6 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1xny |
| Chain | Residue | Details |
| F | SER415 | |
| F | GLY414 | |
| C | GLY181 | |
| C | GLY182 |
