1OKK

HOMO-HETERODIMERIC COMPLEX OF THE SRP GTPASES

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003924	molecular_function	GTPase activity
A	0005525	molecular_function	GTP binding
A	0006614	biological_process	SRP-dependent cotranslational protein targeting to membrane
A	0048500	cellular_component	signal recognition particle
D	0000166	molecular_function	nucleotide binding
D	0003924	molecular_function	GTPase activity
D	0005047	molecular_function	signal recognition particle binding
D	0005515	molecular_function	protein binding
D	0005525	molecular_function	GTP binding
D	0005737	cellular_component	cytoplasm
D	0005886	cellular_component	plasma membrane
D	0006605	biological_process	protein targeting
D	0006612	biological_process	protein targeting to membrane
D	0006614	biological_process	SRP-dependent cotranslational protein targeting to membrane
D	0016020	cellular_component	membrane
D	0016787	molecular_function	hydrolase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	9
Details	BINDING SITE FOR RESIDUE SO4 A1298

Chain	Residue
A	ARG21
A	HOH2344
A	HOH2345
A	HOH2346
A	HOH2347
D	VAL160
D	ILE161
D	GLN162
D	HOH2102

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A1299

Chain	Residue
A	ARG32
A	ARG35
A	ARG49
A	HOH2349

---

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 A1300

Chain	Residue
A	ALA140
A	ALA141
A	ARG142
A	GLU143
A	HOH2202

---

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 A1301

Chain	Residue
A	LYS28
A	ARG286
A	ARG290
A	HOH2350
A	HOH2351
A	HOH2352

---

site_id	AC5
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 A1302

Chain	Residue
A	SER67
A	LEU68
A	THR69
A	HOH2353
A	HOH2354
D	LYS132
D	ARG183
D	TYR185

---

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A1303

Chain	Residue
A	SER164
A	SER167
A	ARG170
A	HOH2355

---

site_id	AC7
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 A1304

Chain	Residue
A	ARG128
A	ARG181

---

site_id	AC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A1305

Chain	Residue
A	ARG169
A	ARG170
A	HOH2356

---

site_id	AC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A1306

Chain	Residue
A	ARG231
A	HOH2357
D	LYS207
D	ARG211

---

site_id	BC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A1307

Chain	Residue
A	ARG142
A	MET160
A	ASP161

---

site_id	BC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 D1308

Chain	Residue
D	ARG124
D	ARG155
D	PRO286
D	HOH2209

---

site_id	BC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG A1002

Chain	Residue
A	THR112
A	GCP1001
A	HOH2196
A	HOH2207
A	HOH2249

---

site_id	BC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG D1002

Chain	Residue
D	THR116
D	GCP1001
D	HOH2082
D	HOH2123
D	HOH2207

---

site_id	BC5
Number of Residues	31
Details	BINDING SITE FOR RESIDUE GCP A1001

Chain	Residue
A	GLN107
A	GLY108
A	SER109
A	GLY110
A	LYS111
A	THR112
A	THR113
A	LYS117
A	ASP135
A	ARG138
A	GLN144
A	GLY190
A	LYS246
A	ASP248
A	GLY271
A	VAL272
A	SER273
A	GLU274
A	MG1002
A	HOH2181
A	HOH2182
A	HOH2196
A	HOH2197
A	HOH2207
A	HOH2249
A	HOH2342
D	ASN111
D	ARG142
D	LEU196
D	GCP1001
D	HOH2065

---

site_id	BC6
Number of Residues	7
Details	BINDING SITE FOR RESIDUE BZP A1296

Chain	Residue
A	ARG290
A	ALA270
A	GLU280
A	PRO281
A	PHE282
A	TYR283
A	ARG286

---

site_id	BC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE BZP A1297

Chain	Residue
A	LYS96
A	ASP97
A	ARG98
A	LYS206
A	HOH2175

---

site_id	BC8
Number of Residues	27
Details	BINDING SITE FOR RESIDUE GCP D1001

Chain	Residue
A	GLN107
A	ARG138
A	GCP1001
D	ASN111
D	GLY112
D	VAL113
D	GLY114
D	LYS115
D	THR116
D	THR117
D	LYS121
D	ARG142
D	GLN148
D	GLY194
D	LYS256
D	ASP258
D	GLY281
D	VAL282
D	GLY283
D	GLU284
D	MG1002
D	HOH2067
D	HOH2082
D	HOH2085
D	HOH2123
D	HOH2207
D	HOH2208

---

site_id	BC9
Number of Residues	7
Details	BINDING SITE FOR RESIDUE EDO D1309

Chain	Residue
A	LEU106
A	GLN193
D	VAL231
D	GLY259
D	THR260
D	ALA261
D	HOH2172

---

site_id	CC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO D1310

Chain	Residue
A	ARG127
D	LYS215
D	EDO1311

---

site_id	CC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO D1311

Chain	Residue
D	TYR174
D	LYS215
D	EDO1310

---

site_id	CC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO D1312

Chain	Residue
D	GLU151
D	TRP152
D	ARG155
D	HOH2210
D	HOH2211

---

Functional Information from PROSITE/UniProt

site_id	PS00300
Number of Residues	14
Details	SRP54 SRP54-type proteins GTP-binding domain signature. PIkFVGVGEgPddL

Chain	Residue	Details
D	PRO276-LEU289
A	PRO266-LEU279

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	14
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00306","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	14
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00920","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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