1OJA

HUMAN MONOAMINE OXIDASE B IN COMPLEX WITH ISATIN

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005515	molecular_function	protein binding
A	0005739	cellular_component	mitochondrion
A	0005740	cellular_component	mitochondrial envelope
A	0005741	cellular_component	mitochondrial outer membrane
A	0008131	molecular_function	primary methylamine oxidase activity
A	0009055	molecular_function	electron transfer activity
A	0016491	molecular_function	oxidoreductase activity
A	0019607	biological_process	phenylethylamine catabolic process
A	0021762	biological_process	substantia nigra development
A	0042420	biological_process	dopamine catabolic process
A	0042428	biological_process	serotonin metabolic process
A	0050665	biological_process	hydrogen peroxide biosynthetic process
A	0097621	molecular_function	monoamine oxidase activity
B	0005515	molecular_function	protein binding
B	0005739	cellular_component	mitochondrion
B	0005740	cellular_component	mitochondrial envelope
B	0005741	cellular_component	mitochondrial outer membrane
B	0008131	molecular_function	primary methylamine oxidase activity
B	0009055	molecular_function	electron transfer activity
B	0016491	molecular_function	oxidoreductase activity
B	0019607	biological_process	phenylethylamine catabolic process
B	0021762	biological_process	substantia nigra development
B	0042420	biological_process	dopamine catabolic process
B	0042428	biological_process	serotonin metabolic process
B	0050665	biological_process	hydrogen peroxide biosynthetic process
B	0097621	molecular_function	monoamine oxidase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	38
Details	BINDING SITE FOR RESIDUE FAD A 600

Chain	Residue
A	GLY11
A	GLY41
A	ARG42
A	THR43
A	GLY58
A	SER59
A	TYR60
A	PRO234
A	VAL235
A	ALA263
A	ILE264
A	GLY13
A	TRP388
A	TYR393
A	CYS397
A	TYR398
A	GLY425
A	THR426
A	GLY434
A	TYR435
A	MET436
A	ALA439
A	ILE14
A	ISN601
A	HOH2016
A	HOH2187
A	HOH2312
A	HOH2313
A	HOH2314
A	HOH2315
A	HOH2316
A	HOH2317
A	SER15
A	LEU33
A	GLU34
A	ALA35
A	ARG36
A	GLY40

---

site_id	AC2
Number of Residues	10
Details	BINDING SITE FOR RESIDUE ISN A 601

Chain	Residue
A	TYR60
A	LEU171
A	GLN206
A	TYR326
A	LEU328
A	PHE343
A	TYR435
A	FAD600
A	HOH2187
A	HOH2318

---

site_id	AC3
Number of Residues	41
Details	BINDING SITE FOR RESIDUE FAD B 600

Chain	Residue
B	VAL10
B	GLY11
B	GLY13
B	ILE14
B	SER15
B	LEU33
B	GLU34
B	ALA35
B	ARG36
B	GLY40
B	GLY41
B	ARG42
B	THR43
B	GLY58
B	SER59
B	TYR60
B	ARG233
B	PRO234
B	VAL235
B	ALA263
B	ILE264
B	TRP388
B	TYR393
B	CYS397
B	TYR398
B	GLY425
B	THR426
B	GLY434
B	TYR435
B	MET436
B	ALA439
B	ISN601
B	HOH2032
B	HOH2212
B	HOH2336
B	HOH2337
B	HOH2338
B	HOH2339
B	HOH2340
B	HOH2341
B	HOH2342

---

site_id	AC4
Number of Residues	9
Details	BINDING SITE FOR RESIDUE ISN B 601

Chain	Residue
B	TYR60
B	GLN206
B	TYR326
B	LEU328
B	PHE343
B	TYR435
B	FAD600
B	HOH2212
B	HOH2342

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	Site: {"description":"Important for catalytic activity"}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"Q8BW75","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Modified residue: {"description":"S-8alpha-FAD cysteine","evidences":[{"source":"PubMed","id":"11753429","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12913124","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15027868","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15710600","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16366596","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1GOS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1OJ9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1OJA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1OJC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1OJD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1S2Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1S2Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1S3B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1S3E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2BK3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2BK4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2BK5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2BYB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2C64","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2C65","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2C66","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2C67","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2C70","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2C72","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2C73","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2C75","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2C76","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2V5Z","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2V60","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2V61","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2VRL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2VRM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2VZ2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2XFN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2XFO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2XFP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2XFQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3PO7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ZYX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4A79","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4A7A","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4CRT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5MRL","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	1
Details	Annotated By Reference To The Literature 1b5q

Chain	Residue	Details
A	GLY62

---

site_id	CSA2
Number of Residues	1
Details	Annotated By Reference To The Literature 1b5q

Chain	Residue	Details
B	GLY62

---