1OJ7
STRUCTURAL GENOMICS, UNKNOWN FUNCTION CRYSTAL STRUCTURE OF E. COLI K-12 YQHD
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000302 | biological_process | response to reactive oxygen species |
| A | 0005829 | cellular_component | cytosol |
| A | 0008106 | molecular_function | alcohol dehydrogenase (NADP+) activity |
| A | 0008270 | molecular_function | zinc ion binding |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| A | 0018455 | molecular_function | alcohol dehydrogenase [NAD(P)+] activity |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0046872 | molecular_function | metal ion binding |
| A | 1990002 | molecular_function | methylglyoxal reductase (NADPH) (acetol producing) activity |
| A | 1990362 | molecular_function | butanol dehydrogenase (NAD+) activity |
| B | 0000302 | biological_process | response to reactive oxygen species |
| B | 0005829 | cellular_component | cytosol |
| B | 0008106 | molecular_function | alcohol dehydrogenase (NADP+) activity |
| B | 0008270 | molecular_function | zinc ion binding |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| B | 0018455 | molecular_function | alcohol dehydrogenase [NAD(P)+] activity |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0046872 | molecular_function | metal ion binding |
| B | 1990002 | molecular_function | methylglyoxal reductase (NADPH) (acetol producing) activity |
| B | 1990362 | molecular_function | butanol dehydrogenase (NAD+) activity |
| C | 0000302 | biological_process | response to reactive oxygen species |
| C | 0005829 | cellular_component | cytosol |
| C | 0008106 | molecular_function | alcohol dehydrogenase (NADP+) activity |
| C | 0008270 | molecular_function | zinc ion binding |
| C | 0016491 | molecular_function | oxidoreductase activity |
| C | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| C | 0018455 | molecular_function | alcohol dehydrogenase [NAD(P)+] activity |
| C | 0042802 | molecular_function | identical protein binding |
| C | 0046872 | molecular_function | metal ion binding |
| C | 1990002 | molecular_function | methylglyoxal reductase (NADPH) (acetol producing) activity |
| C | 1990362 | molecular_function | butanol dehydrogenase (NAD+) activity |
| D | 0000302 | biological_process | response to reactive oxygen species |
| D | 0005829 | cellular_component | cytosol |
| D | 0008106 | molecular_function | alcohol dehydrogenase (NADP+) activity |
| D | 0008270 | molecular_function | zinc ion binding |
| D | 0016491 | molecular_function | oxidoreductase activity |
| D | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| D | 0018455 | molecular_function | alcohol dehydrogenase [NAD(P)+] activity |
| D | 0042802 | molecular_function | identical protein binding |
| D | 0046872 | molecular_function | metal ion binding |
| D | 1990002 | molecular_function | methylglyoxal reductase (NADPH) (acetol producing) activity |
| D | 1990362 | molecular_function | butanol dehydrogenase (NAD+) activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ZN B1389 |
| Chain | Residue |
| B | ASP194 |
| B | HIS198 |
| B | HIS267 |
| B | HIS281 |
| B | NZQ1388 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ZN C1388 |
| Chain | Residue |
| C | BO31390 |
| C | ASP194 |
| C | HIS198 |
| C | HIS267 |
| C | HIS281 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CL C1389 |
| Chain | Residue |
| C | GLY38 |
| C | GLY39 |
| C | SER40 |
| C | HOH2031 |
| C | HOH2064 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE ZN D1389 |
| Chain | Residue |
| D | ASP194 |
| D | HIS198 |
| D | HIS267 |
| D | HIS281 |
| D | LEU285 |
| D | NZQ1388 |
| site_id | AC5 |
| Number of Residues | 44 |
| Details | BINDING SITE FOR RESIDUE NZQ A1388 |
| Chain | Residue |
| A | GLY38 |
| A | GLY39 |
| A | SER40 |
| A | PRO67 |
| A | ASN68 |
| A | GLY94 |
| A | GLY95 |
| A | SER96 |
| A | ASP99 |
| A | THR138 |
| A | LEU139 |
| A | ALA141 |
| A | THR142 |
| A | SER144 |
| A | ASN147 |
| A | GLY149 |
| A | VAL151 |
| A | LYS160 |
| A | TYR179 |
| A | THR182 |
| A | LEU183 |
| A | GLN187 |
| A | ASP194 |
| A | HIS198 |
| A | HIS267 |
| A | HIS271 |
| A | HIS281 |
| A | HOH2069 |
| A | HOH2134 |
| A | HOH2170 |
| A | HOH2352 |
| A | HOH2353 |
| A | HOH2354 |
| A | HOH2355 |
| A | HOH2356 |
| A | HOH2357 |
| A | HOH2358 |
| A | HOH2359 |
| A | HOH2360 |
| A | HOH2361 |
| A | HOH2362 |
| A | HOH2363 |
| A | HOH2364 |
| A | HOH2365 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE BO3 A1389 |
| Chain | Residue |
| A | ARG186 |
| A | ASN190 |
| A | ASP280 |
| A | GLN283 |
| A | GLY338 |
| A | VAL339 |
| site_id | AC7 |
| Number of Residues | 46 |
| Details | BINDING SITE FOR RESIDUE NZQ B1388 |
| Chain | Residue |
| B | HIS281 |
| B | ZN1389 |
| B | HOH2083 |
| B | HOH2161 |
| B | HOH2171 |
| B | HOH2210 |
| B | HOH2417 |
| B | HOH2418 |
| B | HOH2419 |
| B | HOH2420 |
| B | HOH2421 |
| B | HOH2422 |
| B | HOH2423 |
| B | HOH2424 |
| B | HOH2425 |
| B | HOH2426 |
| B | HOH2427 |
| B | HOH2428 |
| B | GLY38 |
| B | GLY39 |
| B | SER40 |
| B | PRO67 |
| B | ASN68 |
| B | GLY94 |
| B | GLY95 |
| B | SER96 |
| B | ASP99 |
| B | THR138 |
| B | LEU139 |
| B | ALA141 |
| B | THR142 |
| B | SER144 |
| B | ASN147 |
| B | GLY149 |
| B | VAL151 |
| B | LYS160 |
| B | TYR179 |
| B | THR182 |
| B | LEU183 |
| B | PRO184 |
| B | GLN187 |
| B | ASP194 |
| B | HIS198 |
| B | LEU252 |
| B | HIS267 |
| B | HIS271 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE BO3 C1390 |
| Chain | Residue |
| C | ASP194 |
| C | HIS198 |
| C | HIS267 |
| C | HIS281 |
| C | ZN1388 |
| site_id | AC9 |
| Number of Residues | 43 |
| Details | BINDING SITE FOR RESIDUE NZQ D1388 |
| Chain | Residue |
| D | GLY38 |
| D | GLY39 |
| D | SER40 |
| D | PRO67 |
| D | ASN68 |
| D | GLY94 |
| D | GLY95 |
| D | SER96 |
| D | ASP99 |
| D | THR138 |
| D | LEU139 |
| D | ALA141 |
| D | THR142 |
| D | SER144 |
| D | ASN147 |
| D | GLY149 |
| D | VAL151 |
| D | LYS160 |
| D | TYR179 |
| D | THR182 |
| D | LEU183 |
| D | GLN187 |
| D | ASP194 |
| D | HIS198 |
| D | HIS267 |
| D | HIS271 |
| D | HIS281 |
| D | ZN1389 |
| D | HOH2090 |
| D | HOH2282 |
| D | HOH2283 |
| D | HOH2284 |
| D | HOH2285 |
| D | HOH2286 |
| D | HOH2287 |
| D | HOH2288 |
| D | HOH2289 |
| D | HOH2290 |
| D | HOH2292 |
| D | HOH2293 |
| D | HOH2294 |
| D | HOH2295 |
| D | HOH2296 |
Functional Information from PROSITE/UniProt
| site_id | PS00060 |
| Number of Residues | 21 |
| Details | ADH_IRON_2 Iron-containing alcohol dehydrogenases signature 2. WaTHmlGHeLTAmhgLdHAqT |
| Chain | Residue | Details |
| A | TRP264-THR284 |
| site_id | PS00913 |
| Number of Residues | 29 |
| Details | ADH_IRON_1 Iron-containing alcohol dehydrogenases signature 1. AVlDpvytytlPprqvAnGvvDAFvhtvE |
| Chain | Residue | Details |
| A | ALA173-GLU201 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 24 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:15327949 |
| Chain | Residue | Details |
| A | GLY38 | |
| B | ASN147 | |
| B | LYS160 | |
| B | TYR179 | |
| C | GLY38 | |
| C | GLY93 | |
| C | THR138 | |
| C | ASN147 | |
| C | LYS160 | |
| C | TYR179 | |
| D | GLY38 | |
| A | GLY93 | |
| D | GLY93 | |
| D | THR138 | |
| D | ASN147 | |
| D | LYS160 | |
| D | TYR179 | |
| A | THR138 | |
| A | ASN147 | |
| A | LYS160 | |
| A | TYR179 | |
| B | GLY38 | |
| B | GLY93 | |
| B | THR138 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 16 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:15327949, ECO:0007744|PDB:1OJ7 |
| Chain | Residue | Details |
| A | ASP194 | |
| C | HIS198 | |
| C | HIS267 | |
| C | HIS281 | |
| D | ASP194 | |
| D | HIS198 | |
| D | HIS267 | |
| D | HIS281 | |
| A | HIS198 | |
| A | HIS267 | |
| A | HIS281 | |
| B | ASP194 | |
| B | HIS198 | |
| B | HIS267 | |
| B | HIS281 | |
| C | ASP194 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1dqs |
| Chain | Residue | Details |
| A | HIS271 |
| site_id | CSA2 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1dqs |
| Chain | Residue | Details |
| B | HIS271 |
| site_id | CSA3 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1dqs |
| Chain | Residue | Details |
| C | HIS271 |
| site_id | CSA4 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1dqs |
| Chain | Residue | Details |
| D | HIS271 |
