1OJ6

Human brain neuroglobin three-dimensional structure

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001666	biological_process	response to hypoxia
A	0005092	molecular_function	GDP-dissociation inhibitor activity
A	0005344	molecular_function	oxygen carrier activity
A	0005515	molecular_function	protein binding
A	0005759	cellular_component	mitochondrial matrix
A	0005829	cellular_component	cytosol
A	0015671	biological_process	oxygen transport
A	0016491	molecular_function	oxidoreductase activity
A	0019825	molecular_function	oxygen binding
A	0020037	molecular_function	heme binding
A	0046872	molecular_function	metal ion binding
A	0071456	biological_process	cellular response to hypoxia
A	0098809	molecular_function	nitrite reductase activity
B	0001666	biological_process	response to hypoxia
B	0005092	molecular_function	GDP-dissociation inhibitor activity
B	0005344	molecular_function	oxygen carrier activity
B	0005515	molecular_function	protein binding
B	0005759	cellular_component	mitochondrial matrix
B	0005829	cellular_component	cytosol
B	0015671	biological_process	oxygen transport
B	0016491	molecular_function	oxidoreductase activity
B	0019825	molecular_function	oxygen binding
B	0020037	molecular_function	heme binding
B	0046872	molecular_function	metal ion binding
B	0071456	biological_process	cellular response to hypoxia
B	0098809	molecular_function	nitrite reductase activity
C	0001666	biological_process	response to hypoxia
C	0005092	molecular_function	GDP-dissociation inhibitor activity
C	0005344	molecular_function	oxygen carrier activity
C	0005515	molecular_function	protein binding
C	0005759	cellular_component	mitochondrial matrix
C	0005829	cellular_component	cytosol
C	0015671	biological_process	oxygen transport
C	0016491	molecular_function	oxidoreductase activity
C	0019825	molecular_function	oxygen binding
C	0020037	molecular_function	heme binding
C	0046872	molecular_function	metal ion binding
C	0071456	biological_process	cellular response to hypoxia
C	0098809	molecular_function	nitrite reductase activity
D	0001666	biological_process	response to hypoxia
D	0005092	molecular_function	GDP-dissociation inhibitor activity
D	0005344	molecular_function	oxygen carrier activity
D	0005515	molecular_function	protein binding
D	0005759	cellular_component	mitochondrial matrix
D	0005829	cellular_component	cytosol
D	0015671	biological_process	oxygen transport
D	0016491	molecular_function	oxidoreductase activity
D	0019825	molecular_function	oxygen binding
D	0020037	molecular_function	heme binding
D	0046872	molecular_function	metal ion binding
D	0071456	biological_process	cellular response to hypoxia
D	0098809	molecular_function	nitrite reductase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 B1153

Chain	Residue
B	SER51
B	HOH2041

---

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 B1154

Chain	Residue
A	LEU70
A	ALA74
B	TYR88
B	HOH2028
B	HOH2042

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 B1155

Chain	Residue
B	SER104
B	HOH2031
B	MET1
B	LEU103

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 B1156

Chain	Residue
B	SER19
B	PRO20
B	LEU21
B	GLU22

---

site_id	AC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 C1153

Chain	Residue
C	TYR88
C	HEM1152
C	HOH2020

---

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 C1154

Chain	Residue
C	SER19
C	PRO20
C	LEU21
C	GLU22

---

site_id	AC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 C1155

Chain	Residue
C	LYS102
C	LEU103
C	SER104

---

site_id	AC8
Number of Residues	10
Details	BINDING SITE FOR RESIDUE HEM A1150

Chain	Residue
A	HIS64
A	LYS67
A	VAL68
A	VAL71
A	LEU92
A	HIS96
A	PHE106
A	VAL109
A	HOH2038
B	ASP73

---

site_id	AC9
Number of Residues	16
Details	BINDING SITE FOR RESIDUE HEM B1152

Chain	Residue
A	THR77
A	ASN78
B	LEU41
B	PHE42
B	TYR44
B	HIS64
B	LYS67
B	VAL68
B	VAL71
B	TYR88
B	LEU92
B	LYS95
B	HIS96
B	VAL109
B	HOH2039
B	HOH2040

---

site_id	BC1
Number of Residues	14
Details	BINDING SITE FOR RESIDUE HEM C1152

Chain	Residue
C	LEU38
C	LEU41
C	PHE42
C	TYR44
C	HIS64
C	LYS67
C	VAL68
C	LEU92
C	LYS95
C	HIS96
C	PHE106
C	VAL109
C	SO41153
C	HOH2032

---

site_id	BC2
Number of Residues	10
Details	BINDING SITE FOR RESIDUE HEM D1151

Chain	Residue
D	PHE42
D	HIS64
D	LYS67
D	VAL68
D	VAL71
D	TYR88
D	LEU92
D	HIS96
D	VAL109
D	HOH2031

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Binding site: {"description":"distal binding residue; reversible","evidences":[{"source":"PROSITE-ProRule","id":"PRU00238","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"12962627","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24699645","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1OJ6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4MPM","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	Binding site: {"description":"proximal binding residue","evidences":[{"source":"PubMed","id":"12962627","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24699645","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1OJ6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4MPM","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	296
Details	Domain: {"description":"Globin","evidences":[{"source":"PROSITE-ProRule","id":"PRU00238","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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