1OJ4
Ternary complex of 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0005524 | molecular_function | ATP binding |
| A | 0008299 | biological_process | isoprenoid biosynthetic process |
| A | 0016114 | biological_process | terpenoid biosynthetic process |
| A | 0016301 | molecular_function | kinase activity |
| A | 0016740 | molecular_function | transferase activity |
| A | 0019288 | biological_process | isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway |
| A | 0050515 | molecular_function | 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase activity |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0005524 | molecular_function | ATP binding |
| B | 0008299 | biological_process | isoprenoid biosynthetic process |
| B | 0016114 | biological_process | terpenoid biosynthetic process |
| B | 0016301 | molecular_function | kinase activity |
| B | 0016740 | molecular_function | transferase activity |
| B | 0019288 | biological_process | isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway |
| B | 0050515 | molecular_function | 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL A1286 |
| Chain | Residue |
| A | ARG147 |
| A | HOH2095 |
| A | HOH2096 |
| site_id | AC2 |
| Number of Residues | 21 |
| Details | BINDING SITE FOR RESIDUE CDM A1284 |
| Chain | Residue |
| A | ALA140 |
| A | ASP141 |
| A | VAL156 |
| A | THR181 |
| A | PHE185 |
| A | ANP1285 |
| A | HOH2093 |
| A | HOH2101 |
| A | HOH2184 |
| A | HOH2185 |
| A | HOH2186 |
| A | HOH2187 |
| A | HOH2188 |
| A | HOH2189 |
| A | HOH2190 |
| A | LYS10 |
| A | ASN12 |
| A | GLY24 |
| A | TYR25 |
| A | HIS26 |
| A | GLY139 |
| site_id | AC3 |
| Number of Residues | 21 |
| Details | BINDING SITE FOR RESIDUE ANP A1285 |
| Chain | Residue |
| A | LYS10 |
| A | VAL60 |
| A | ASN65 |
| A | LEU66 |
| A | LYS96 |
| A | MSE100 |
| A | GLY101 |
| A | GLY102 |
| A | GLY103 |
| A | LEU104 |
| A | GLY105 |
| A | GLY106 |
| A | GLY107 |
| A | SER108 |
| A | ASN110 |
| A | CDM1284 |
| A | HOH2068 |
| A | HOH2184 |
| A | HOH2188 |
| A | HOH2190 |
| A | HOH2192 |
| site_id | AC4 |
| Number of Residues | 21 |
| Details | BINDING SITE FOR RESIDUE CDM B1284 |
| Chain | Residue |
| B | LYS10 |
| B | ASN12 |
| B | GLY24 |
| B | TYR25 |
| B | HIS26 |
| B | LEU28 |
| B | PHE32 |
| B | SER108 |
| B | ALA140 |
| B | ASP141 |
| B | VAL156 |
| B | THR181 |
| B | PHE185 |
| B | THR240 |
| B | ANP1285 |
| B | HOH2104 |
| B | HOH2186 |
| B | HOH2187 |
| B | HOH2188 |
| B | HOH2189 |
| B | HOH2190 |
| site_id | AC5 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE ANP B1285 |
| Chain | Residue |
| B | ASP64 |
| B | ASN65 |
| B | LEU66 |
| B | LYS96 |
| B | PRO99 |
| B | MSE100 |
| B | GLY101 |
| B | GLY103 |
| B | LEU104 |
| B | GLY105 |
| B | GLY106 |
| B | GLY107 |
| B | SER108 |
| B | ASN110 |
| B | CDM1284 |
| B | HOH2189 |
| B | HOH2190 |
| B | HOH2191 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | Active site: {"evidences":[{"evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | a catalytic site defined by CSA, PubMed 12878729, 12771135 |
| Chain | Residue | Details |
| A | LYS10 | |
| A | ASP141 |
| site_id | CSA2 |
| Number of Residues | 2 |
| Details | a catalytic site defined by CSA, PubMed 12878729, 12771135 |
| Chain | Residue | Details |
| B | LYS10 | |
| B | ASP141 |
| site_id | MCSA1 |
| Number of Residues | 2 |
| Details | M-CSA 654 |
| Chain | Residue | Details |
| A | PHE14 | electrostatic stabiliser, hydrogen bond donor |
| A | THR161 | activator, proton acceptor, proton donor |
| site_id | MCSA2 |
| Number of Residues | 2 |
| Details | M-CSA 654 |
| Chain | Residue | Details |
| B | PHE14 | electrostatic stabiliser, hydrogen bond donor |
| B | THR161 | activator, proton acceptor, proton donor |
