1OIZ
The Molecular Basis of Vitamin E Retention: Structure of Human Alpha-Tocopherol Transfer Protein
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005515 | molecular_function | protein binding |
| A | 0005546 | molecular_function | phosphatidylinositol-4,5-bisphosphate binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005770 | cellular_component | late endosome |
| A | 0005829 | cellular_component | cytosol |
| A | 0006629 | biological_process | lipid metabolic process |
| A | 0008289 | molecular_function | lipid binding |
| A | 0008431 | molecular_function | vitamin E binding |
| A | 0009636 | biological_process | response to toxic substance |
| A | 0042360 | biological_process | vitamin E metabolic process |
| A | 0043325 | molecular_function | phosphatidylinositol-3,4-bisphosphate binding |
| A | 0051180 | biological_process | vitamin transport |
| A | 0090212 | biological_process | negative regulation of establishment of blood-brain barrier |
| A | 0120009 | biological_process | intermembrane lipid transfer |
| A | 0120013 | molecular_function | lipid transfer activity |
| A | 1902936 | molecular_function | phosphatidylinositol bisphosphate binding |
| B | 0005515 | molecular_function | protein binding |
| B | 0005546 | molecular_function | phosphatidylinositol-4,5-bisphosphate binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005770 | cellular_component | late endosome |
| B | 0005829 | cellular_component | cytosol |
| B | 0006629 | biological_process | lipid metabolic process |
| B | 0008289 | molecular_function | lipid binding |
| B | 0008431 | molecular_function | vitamin E binding |
| B | 0009636 | biological_process | response to toxic substance |
| B | 0042360 | biological_process | vitamin E metabolic process |
| B | 0043325 | molecular_function | phosphatidylinositol-3,4-bisphosphate binding |
| B | 0051180 | biological_process | vitamin transport |
| B | 0090212 | biological_process | negative regulation of establishment of blood-brain barrier |
| B | 0120009 | biological_process | intermembrane lipid transfer |
| B | 0120013 | molecular_function | lipid transfer activity |
| B | 1902936 | molecular_function | phosphatidylinositol bisphosphate binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE TRT A1274 |
| Chain | Residue |
| A | TRP163 |
| A | HOH2146 |
| B | PHE213 |
| A | PHE165 |
| A | ALA168 |
| A | ILE202 |
| A | PHE203 |
| A | VAL206 |
| A | ILE222 |
| A | MET224 |
| A | TRT1276 |
| site_id | AC2 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE TRT A1275 |
| Chain | Residue |
| A | LEU115 |
| A | TYR117 |
| A | SER136 |
| A | SER140 |
| A | ILE143 |
| A | ILE154 |
| A | VAL182 |
| A | LEU189 |
| A | VAL191 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE TRT A1276 |
| Chain | Residue |
| A | TRP163 |
| A | ALA168 |
| A | ILE171 |
| A | TRT1274 |
| B | VAL206 |
| B | MET209 |
| B | TRT1276 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE TRT B1275 |
| Chain | Residue |
| B | PHE165 |
| B | ILE202 |
| B | VAL206 |
| B | ILE222 |
| B | MET224 |
| B | TRT1276 |
| site_id | AC5 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE TRT B1276 |
| Chain | Residue |
| A | MET209 |
| A | ILE210 |
| A | TRT1276 |
| B | ILE179 |
| B | TRT1275 |
| B | TRT1277 |
| B | HOH2148 |
| site_id | AC6 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE TRT B1277 |
| Chain | Residue |
| B | TYR100 |
| B | LEU115 |
| B | TYR117 |
| B | ILE119 |
| B | VAL132 |
| B | PHE133 |
| B | SER136 |
| B | SER140 |
| B | ILE154 |
| B | ALA156 |
| B | PHE158 |
| B | ILE171 |
| B | ILE179 |
| B | LEU183 |
| B | LEU189 |
| B | VAL191 |
| B | TRT1276 |
| B | HOH2091 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 330 |
| Details | Domain: {"description":"CRAL-TRIO","evidences":[{"source":"PROSITE-ProRule","id":"PRU00056","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 18 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"Q8BWP5","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
