1OG0
CRYSTAL STRUCTURE OF THE MUTANT G226S OF THE TYROSINE-REGULATED 3-DEOXY-D-ARABINO-HEPTULOSONATE-7-PHOSPHATE SYNTHASE FROM SACCHAROMYCES CEREVISIAE COMPLEXED WITH PHENYLALANINE AND MANGANESE
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003849 | molecular_function | 3-deoxy-7-phosphoheptulonate synthase activity |
| A | 0005634 | cellular_component | nucleus |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0009058 | biological_process | biosynthetic process |
| A | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
| A | 0009423 | biological_process | chorismate biosynthetic process |
| A | 0043085 | biological_process | positive regulation of catalytic activity |
| A | 0046417 | biological_process | chorismate metabolic process |
| B | 0003849 | molecular_function | 3-deoxy-7-phosphoheptulonate synthase activity |
| B | 0005634 | cellular_component | nucleus |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0009058 | biological_process | biosynthetic process |
| B | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
| B | 0009423 | biological_process | chorismate biosynthetic process |
| B | 0043085 | biological_process | positive regulation of catalytic activity |
| B | 0046417 | biological_process | chorismate metabolic process |
| C | 0003849 | molecular_function | 3-deoxy-7-phosphoheptulonate synthase activity |
| C | 0005634 | cellular_component | nucleus |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005829 | cellular_component | cytosol |
| C | 0009058 | biological_process | biosynthetic process |
| C | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
| C | 0009423 | biological_process | chorismate biosynthetic process |
| C | 0043085 | biological_process | positive regulation of catalytic activity |
| C | 0046417 | biological_process | chorismate metabolic process |
| D | 0003849 | molecular_function | 3-deoxy-7-phosphoheptulonate synthase activity |
| D | 0005634 | cellular_component | nucleus |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005829 | cellular_component | cytosol |
| D | 0009058 | biological_process | biosynthetic process |
| D | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
| D | 0009423 | biological_process | chorismate biosynthetic process |
| D | 0043085 | biological_process | positive regulation of catalytic activity |
| D | 0046417 | biological_process | chorismate metabolic process |
| E | 0003849 | molecular_function | 3-deoxy-7-phosphoheptulonate synthase activity |
| E | 0005634 | cellular_component | nucleus |
| E | 0005737 | cellular_component | cytoplasm |
| E | 0005829 | cellular_component | cytosol |
| E | 0009058 | biological_process | biosynthetic process |
| E | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
| E | 0009423 | biological_process | chorismate biosynthetic process |
| E | 0043085 | biological_process | positive regulation of catalytic activity |
| E | 0046417 | biological_process | chorismate metabolic process |
| F | 0003849 | molecular_function | 3-deoxy-7-phosphoheptulonate synthase activity |
| F | 0005634 | cellular_component | nucleus |
| F | 0005737 | cellular_component | cytoplasm |
| F | 0005829 | cellular_component | cytosol |
| F | 0009058 | biological_process | biosynthetic process |
| F | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
| F | 0009423 | biological_process | chorismate biosynthetic process |
| F | 0043085 | biological_process | positive regulation of catalytic activity |
| F | 0046417 | biological_process | chorismate metabolic process |
| G | 0003849 | molecular_function | 3-deoxy-7-phosphoheptulonate synthase activity |
| G | 0005634 | cellular_component | nucleus |
| G | 0005737 | cellular_component | cytoplasm |
| G | 0005829 | cellular_component | cytosol |
| G | 0009058 | biological_process | biosynthetic process |
| G | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
| G | 0009423 | biological_process | chorismate biosynthetic process |
| G | 0043085 | biological_process | positive regulation of catalytic activity |
| G | 0046417 | biological_process | chorismate metabolic process |
| H | 0003849 | molecular_function | 3-deoxy-7-phosphoheptulonate synthase activity |
| H | 0005634 | cellular_component | nucleus |
| H | 0005737 | cellular_component | cytoplasm |
| H | 0005829 | cellular_component | cytosol |
| H | 0009058 | biological_process | biosynthetic process |
| H | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
| H | 0009423 | biological_process | chorismate biosynthetic process |
| H | 0043085 | biological_process | positive regulation of catalytic activity |
| H | 0046417 | biological_process | chorismate metabolic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MN A 400 |
| Chain | Residue |
| A | CYS76 |
| A | HIS282 |
| A | GLU316 |
| A | ASP342 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MN B 400 |
| Chain | Residue |
| B | CYS76 |
| B | HIS282 |
| B | GLU316 |
| B | ASP342 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MN C 400 |
| Chain | Residue |
| C | HIS282 |
| C | GLU316 |
| C | ASP342 |
| C | HOH2014 |
| C | CYS76 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MN D 400 |
| Chain | Residue |
| D | CYS76 |
| D | HIS282 |
| D | GLU316 |
| D | ASP342 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MN E 400 |
| Chain | Residue |
| E | CYS76 |
| E | HIS282 |
| E | GLU316 |
| E | ASP342 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MN F 400 |
| Chain | Residue |
| F | CYS76 |
| F | HIS282 |
| F | GLU316 |
| F | ASP342 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MN G 400 |
| Chain | Residue |
| G | CYS76 |
| G | ARG107 |
| G | HIS282 |
| G | GLU316 |
| G | ASP342 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MN H 400 |
| Chain | Residue |
| H | CYS76 |
| H | HIS282 |
| H | GLU316 |
| H | ASP342 |
| site_id | AC9 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE PHE A 1012 |
| Chain | Residue |
| A | THR162 |
| A | GLN166 |
| A | ALA169 |
| A | GLY193 |
| A | LEU194 |
| A | SER195 |
| A | SER226 |
| A | LYS229 |
| B | GLU21 |
| B | ASP22 |
| B | TYR28 |
| site_id | BC1 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE PHE C 1012 |
| Chain | Residue |
| C | GLN166 |
| C | ALA169 |
| C | GLY193 |
| C | LEU194 |
| C | SER195 |
| D | GLU21 |
| D | ASP22 |
| D | ILE25 |
| D | TYR28 |
| site_id | BC2 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE PHE D 1012 |
| Chain | Residue |
| C | GLU21 |
| C | ASP22 |
| C | ILE25 |
| C | TYR28 |
| D | THR162 |
| D | PRO165 |
| D | GLN166 |
| D | ALA169 |
| D | GLY193 |
| D | LEU194 |
| D | SER195 |
| site_id | BC3 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE PHE E 1012 |
| Chain | Residue |
| E | GLU21 |
| E | ASP22 |
| E | ILE25 |
| F | THR162 |
| F | PRO165 |
| F | GLN166 |
| F | ALA169 |
| F | GLY193 |
| F | LEU194 |
| F | SER195 |
| site_id | BC4 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE PHE F 1012 |
| Chain | Residue |
| E | THR162 |
| E | GLN166 |
| E | ALA169 |
| E | LEU190 |
| E | GLY193 |
| E | LEU194 |
| E | SER195 |
| E | HOH2004 |
| F | GLU21 |
| F | ASP22 |
| F | TYR28 |
| site_id | BC5 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE PHE G 1012 |
| Chain | Residue |
| G | THR162 |
| G | GLN166 |
| G | ALA169 |
| G | LEU190 |
| G | GLY193 |
| G | SER195 |
| H | ASP22 |
| H | TYR28 |
| site_id | BC6 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE PHE H 1012 |
| Chain | Residue |
| H | GLN166 |
| H | ALA169 |
| H | GLY193 |
| H | LEU194 |
| H | SER195 |
| G | GLU21 |
| G | ASP22 |
| G | TYR28 |
| H | THR162 |
| H | PRO165 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 54 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU01406","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1q3n |
| Chain | Residue | Details |
| A | HIS282 |
| site_id | CSA2 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1q3n |
| Chain | Residue | Details |
| B | HIS282 |
| site_id | CSA3 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1q3n |
| Chain | Residue | Details |
| C | HIS282 |
| site_id | CSA4 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1q3n |
| Chain | Residue | Details |
| D | HIS282 |
| site_id | CSA5 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1q3n |
| Chain | Residue | Details |
| E | HIS282 |
| site_id | CSA6 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1q3n |
| Chain | Residue | Details |
| F | HIS282 |
| site_id | CSA7 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1q3n |
| Chain | Residue | Details |
| G | HIS282 |
| site_id | CSA8 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1q3n |
| Chain | Residue | Details |
| H | HIS282 |
