1OF8
double complex of the tyrosine sensitive DAHP Synthase from S. cerevisiae with Co2+, PEP and the E4P analogoue G3P
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003849 | molecular_function | 3-deoxy-7-phosphoheptulonate synthase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0008652 | biological_process | amino acid biosynthetic process |
| A | 0009058 | biological_process | biosynthetic process |
| A | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
| A | 0009423 | biological_process | chorismate biosynthetic process |
| A | 0016740 | molecular_function | transferase activity |
| A | 0043085 | biological_process | positive regulation of catalytic activity |
| B | 0003849 | molecular_function | 3-deoxy-7-phosphoheptulonate synthase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005634 | cellular_component | nucleus |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0008652 | biological_process | amino acid biosynthetic process |
| B | 0009058 | biological_process | biosynthetic process |
| B | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
| B | 0009423 | biological_process | chorismate biosynthetic process |
| B | 0016740 | molecular_function | transferase activity |
| B | 0043085 | biological_process | positive regulation of catalytic activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CO A 1369 |
| Chain | Residue |
| A | CYS76 |
| A | HIS282 |
| A | GLU316 |
| A | ASP342 |
| A | PEP1370 |
| A | HOH2383 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CO B 1372 |
| Chain | Residue |
| B | ASP342 |
| B | PEP1373 |
| B | HOH2393 |
| B | CYS76 |
| B | HIS282 |
| B | GLU316 |
| site_id | AC3 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE PEP A 1370 |
| Chain | Residue |
| A | ARG107 |
| A | TYR109 |
| A | LYS112 |
| A | GLU158 |
| A | GLY178 |
| A | ALA179 |
| A | ARG180 |
| A | LYS201 |
| A | ARG249 |
| A | HIS282 |
| A | CO1369 |
| A | G3P1371 |
| A | HOH2191 |
| A | HOH2383 |
| A | HOH2384 |
| A | HOH2385 |
| A | HOH2386 |
| site_id | AC4 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE G3P A 1371 |
| Chain | Residue |
| A | LYS112 |
| A | PRO113 |
| A | ARG114 |
| A | THR115 |
| A | ASP342 |
| A | PEP1370 |
| A | HOH2133 |
| A | HOH2366 |
| A | HOH2386 |
| A | HOH2387 |
| A | HOH2388 |
| A | HOH2389 |
| site_id | AC5 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE PEP B 1373 |
| Chain | Residue |
| B | ARG107 |
| B | TYR109 |
| B | LYS112 |
| B | GLY178 |
| B | ALA179 |
| B | ARG180 |
| B | LYS201 |
| B | ARG249 |
| B | HIS282 |
| B | CO1372 |
| B | G3P1374 |
| B | HOH2203 |
| B | HOH2393 |
| B | HOH2394 |
| B | HOH2395 |
| B | HOH2396 |
| site_id | AC6 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE G3P B 1374 |
| Chain | Residue |
| B | LYS112 |
| B | PRO113 |
| B | ARG114 |
| B | THR115 |
| B | ASP342 |
| B | PEP1373 |
| B | HOH2373 |
| B | HOH2394 |
| B | HOH2397 |
| B | HOH2398 |
| B | HOH2399 |
| B | HOH2400 |
| B | HOH2401 |
| site_id | AC7 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GOL A 1372 |
| Chain | Residue |
| A | GLN185 |
| A | GLU189 |
| A | PHE224 |
| B | GLU111 |
| B | ASP161 |
| B | HOH2124 |
| B | HOH2127 |
| B | HOH2207 |
| site_id | AC8 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GOL B 1371 |
| Chain | Residue |
| A | GLU111 |
| A | ASP161 |
| A | HOH2119 |
| A | HOH2195 |
| A | HOH2196 |
| B | GLN185 |
| B | GLU189 |
| B | PHE224 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1q3n |
| Chain | Residue | Details |
| A | HIS282 |
| site_id | CSA2 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1q3n |
| Chain | Residue | Details |
| B | HIS282 |
