1OEZ

Zn His46Arg mutant of Human Cu, Zn Superoxide Dismutase

Functional Information from GO Data

Chain	GOid	namespace	contents
W	0000303	biological_process	response to superoxide
W	0001541	biological_process	ovarian follicle development
W	0001819	biological_process	positive regulation of cytokine production
W	0001890	biological_process	placenta development
W	0001895	biological_process	retina homeostasis
W	0001975	biological_process	response to amphetamine
W	0002262	biological_process	myeloid cell homeostasis
W	0004784	molecular_function	superoxide dismutase activity
W	0005507	molecular_function	copper ion binding
W	0005515	molecular_function	protein binding
W	0005576	cellular_component	extracellular region
W	0005615	cellular_component	extracellular space
W	0005634	cellular_component	nucleus
W	0005654	cellular_component	nucleoplasm
W	0005737	cellular_component	cytoplasm
W	0005739	cellular_component	mitochondrion
W	0005758	cellular_component	mitochondrial intermembrane space
W	0005759	cellular_component	mitochondrial matrix
W	0005764	cellular_component	lysosome
W	0005777	cellular_component	peroxisome
W	0005829	cellular_component	cytosol
W	0005886	cellular_component	plasma membrane
W	0006749	biological_process	glutathione metabolic process
W	0006801	biological_process	superoxide metabolic process
W	0006879	biological_process	intracellular iron ion homeostasis
W	0006979	biological_process	response to oxidative stress
W	0007283	biological_process	spermatogenesis
W	0007566	biological_process	embryo implantation
W	0007605	biological_process	sensory perception of sound
W	0007626	biological_process	locomotory behavior
W	0008089	biological_process	anterograde axonal transport
W	0008090	biological_process	retrograde axonal transport
W	0008217	biological_process	regulation of blood pressure
W	0008270	molecular_function	zinc ion binding
W	0009408	biological_process	response to heat
W	0019226	biological_process	transmission of nerve impulse
W	0019430	biological_process	removal of superoxide radicals
W	0019899	molecular_function	enzyme binding
W	0030141	cellular_component	secretory granule
W	0030346	molecular_function	protein phosphatase 2B binding
W	0031045	cellular_component	dense core granule
W	0031267	molecular_function	small GTPase binding
W	0031410	cellular_component	cytoplasmic vesicle
W	0031667	biological_process	response to nutrient levels
W	0032287	biological_process	peripheral nervous system myelin maintenance
W	0032839	cellular_component	dendrite cytoplasm
W	0032930	biological_process	positive regulation of superoxide anion generation
W	0032991	cellular_component	protein-containing complex
W	0033081	biological_process	regulation of T cell differentiation in thymus
W	0034465	biological_process	response to carbon monoxide
W	0034599	biological_process	cellular response to oxidative stress
W	0035865	biological_process	cellular response to potassium ion
W	0040014	biological_process	regulation of multicellular organism growth
W	0042542	biological_process	response to hydrogen peroxide
W	0042802	molecular_function	identical protein binding
W	0042803	molecular_function	protein homodimerization activity
W	0043025	cellular_component	neuronal cell body
W	0043065	biological_process	positive regulation of apoptotic process
W	0043066	biological_process	negative regulation of apoptotic process
W	0043087	biological_process	regulation of GTPase activity
W	0043410	biological_process	positive regulation of MAPK cascade
W	0043524	biological_process	negative regulation of neuron apoptotic process
W	0045471	biological_process	response to ethanol
W	0046620	biological_process	regulation of organ growth
W	0046688	biological_process	response to copper ion
W	0046716	biological_process	muscle cell cellular homeostasis
W	0046872	molecular_function	metal ion binding
W	0048538	biological_process	thymus development
W	0048678	biological_process	response to axon injury
W	0050665	biological_process	hydrogen peroxide biosynthetic process
W	0050728	biological_process	negative regulation of inflammatory response
W	0050766	biological_process	positive regulation of phagocytosis
W	0051087	molecular_function	protein-folding chaperone binding
W	0051881	biological_process	regulation of mitochondrial membrane potential
W	0060047	biological_process	heart contraction
W	0060052	biological_process	neurofilament cytoskeleton organization
W	0060087	biological_process	relaxation of vascular associated smooth muscle
W	0060088	biological_process	auditory receptor cell stereocilium organization
W	0070062	cellular_component	extracellular exosome
W	0071276	biological_process	cellular response to cadmium ion
W	0071318	biological_process	cellular response to ATP
W	0072593	biological_process	reactive oxygen species metabolic process
W	0097332	biological_process	response to antipsychotic drug
W	1902177	biological_process	positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
W	1904115	cellular_component	axon cytoplasm
X	0000303	biological_process	response to superoxide
X	0001541	biological_process	ovarian follicle development
X	0001819	biological_process	positive regulation of cytokine production
X	0001890	biological_process	placenta development
X	0001895	biological_process	retina homeostasis
X	0001975	biological_process	response to amphetamine
X	0002262	biological_process	myeloid cell homeostasis
X	0004784	molecular_function	superoxide dismutase activity
X	0005507	molecular_function	copper ion binding
X	0005515	molecular_function	protein binding
X	0005576	cellular_component	extracellular region
X	0005615	cellular_component	extracellular space
X	0005634	cellular_component	nucleus
X	0005654	cellular_component	nucleoplasm
X	0005737	cellular_component	cytoplasm
X	0005739	cellular_component	mitochondrion
X	0005758	cellular_component	mitochondrial intermembrane space
X	0005759	cellular_component	mitochondrial matrix
X	0005764	cellular_component	lysosome
X	0005777	cellular_component	peroxisome
X	0005829	cellular_component	cytosol
X	0005886	cellular_component	plasma membrane
X	0006749	biological_process	glutathione metabolic process
X	0006801	biological_process	superoxide metabolic process
X	0006879	biological_process	intracellular iron ion homeostasis
X	0006979	biological_process	response to oxidative stress
X	0007283	biological_process	spermatogenesis
X	0007566	biological_process	embryo implantation
X	0007605	biological_process	sensory perception of sound
X	0007626	biological_process	locomotory behavior
X	0008089	biological_process	anterograde axonal transport
X	0008090	biological_process	retrograde axonal transport
X	0008217	biological_process	regulation of blood pressure
X	0008270	molecular_function	zinc ion binding
X	0009408	biological_process	response to heat
X	0019226	biological_process	transmission of nerve impulse
X	0019430	biological_process	removal of superoxide radicals
X	0019899	molecular_function	enzyme binding
X	0030141	cellular_component	secretory granule
X	0030346	molecular_function	protein phosphatase 2B binding
X	0031045	cellular_component	dense core granule
X	0031267	molecular_function	small GTPase binding
X	0031410	cellular_component	cytoplasmic vesicle
X	0031667	biological_process	response to nutrient levels
X	0032287	biological_process	peripheral nervous system myelin maintenance
X	0032839	cellular_component	dendrite cytoplasm
X	0032930	biological_process	positive regulation of superoxide anion generation
X	0032991	cellular_component	protein-containing complex
X	0033081	biological_process	regulation of T cell differentiation in thymus
X	0034465	biological_process	response to carbon monoxide
X	0034599	biological_process	cellular response to oxidative stress
X	0035865	biological_process	cellular response to potassium ion
X	0040014	biological_process	regulation of multicellular organism growth
X	0042542	biological_process	response to hydrogen peroxide
X	0042802	molecular_function	identical protein binding
X	0042803	molecular_function	protein homodimerization activity
X	0043025	cellular_component	neuronal cell body
X	0043065	biological_process	positive regulation of apoptotic process
X	0043066	biological_process	negative regulation of apoptotic process
X	0043087	biological_process	regulation of GTPase activity
X	0043410	biological_process	positive regulation of MAPK cascade
X	0043524	biological_process	negative regulation of neuron apoptotic process
X	0045471	biological_process	response to ethanol
X	0046620	biological_process	regulation of organ growth
X	0046688	biological_process	response to copper ion
X	0046716	biological_process	muscle cell cellular homeostasis
X	0046872	molecular_function	metal ion binding
X	0048538	biological_process	thymus development
X	0048678	biological_process	response to axon injury
X	0050665	biological_process	hydrogen peroxide biosynthetic process
X	0050728	biological_process	negative regulation of inflammatory response
X	0050766	biological_process	positive regulation of phagocytosis
X	0051087	molecular_function	protein-folding chaperone binding
X	0051881	biological_process	regulation of mitochondrial membrane potential
X	0060047	biological_process	heart contraction
X	0060052	biological_process	neurofilament cytoskeleton organization
X	0060087	biological_process	relaxation of vascular associated smooth muscle
X	0060088	biological_process	auditory receptor cell stereocilium organization
X	0070062	cellular_component	extracellular exosome
X	0071276	biological_process	cellular response to cadmium ion
X	0071318	biological_process	cellular response to ATP
X	0072593	biological_process	reactive oxygen species metabolic process
X	0097332	biological_process	response to antipsychotic drug
X	1902177	biological_process	positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
X	1904115	cellular_component	axon cytoplasm
Y	0000303	biological_process	response to superoxide
Y	0001541	biological_process	ovarian follicle development
Y	0001819	biological_process	positive regulation of cytokine production
Y	0001890	biological_process	placenta development
Y	0001895	biological_process	retina homeostasis
Y	0001975	biological_process	response to amphetamine
Y	0002262	biological_process	myeloid cell homeostasis
Y	0004784	molecular_function	superoxide dismutase activity
Y	0005507	molecular_function	copper ion binding
Y	0005515	molecular_function	protein binding
Y	0005576	cellular_component	extracellular region
Y	0005615	cellular_component	extracellular space
Y	0005634	cellular_component	nucleus
Y	0005654	cellular_component	nucleoplasm
Y	0005737	cellular_component	cytoplasm
Y	0005739	cellular_component	mitochondrion
Y	0005758	cellular_component	mitochondrial intermembrane space
Y	0005759	cellular_component	mitochondrial matrix
Y	0005764	cellular_component	lysosome
Y	0005777	cellular_component	peroxisome
Y	0005829	cellular_component	cytosol
Y	0005886	cellular_component	plasma membrane
Y	0006749	biological_process	glutathione metabolic process
Y	0006801	biological_process	superoxide metabolic process
Y	0006879	biological_process	intracellular iron ion homeostasis
Y	0006979	biological_process	response to oxidative stress
Y	0007283	biological_process	spermatogenesis
Y	0007566	biological_process	embryo implantation
Y	0007605	biological_process	sensory perception of sound
Y	0007626	biological_process	locomotory behavior
Y	0008089	biological_process	anterograde axonal transport
Y	0008090	biological_process	retrograde axonal transport
Y	0008217	biological_process	regulation of blood pressure
Y	0008270	molecular_function	zinc ion binding
Y	0009408	biological_process	response to heat
Y	0019226	biological_process	transmission of nerve impulse
Y	0019430	biological_process	removal of superoxide radicals
Y	0019899	molecular_function	enzyme binding
Y	0030141	cellular_component	secretory granule
Y	0030346	molecular_function	protein phosphatase 2B binding
Y	0031045	cellular_component	dense core granule
Y	0031267	molecular_function	small GTPase binding
Y	0031410	cellular_component	cytoplasmic vesicle
Y	0031667	biological_process	response to nutrient levels
Y	0032287	biological_process	peripheral nervous system myelin maintenance
Y	0032839	cellular_component	dendrite cytoplasm
Y	0032930	biological_process	positive regulation of superoxide anion generation
Y	0032991	cellular_component	protein-containing complex
Y	0033081	biological_process	regulation of T cell differentiation in thymus
Y	0034465	biological_process	response to carbon monoxide
Y	0034599	biological_process	cellular response to oxidative stress
Y	0035865	biological_process	cellular response to potassium ion
Y	0040014	biological_process	regulation of multicellular organism growth
Y	0042542	biological_process	response to hydrogen peroxide
Y	0042802	molecular_function	identical protein binding
Y	0042803	molecular_function	protein homodimerization activity
Y	0043025	cellular_component	neuronal cell body
Y	0043065	biological_process	positive regulation of apoptotic process
Y	0043066	biological_process	negative regulation of apoptotic process
Y	0043087	biological_process	regulation of GTPase activity
Y	0043410	biological_process	positive regulation of MAPK cascade
Y	0043524	biological_process	negative regulation of neuron apoptotic process
Y	0045471	biological_process	response to ethanol
Y	0046620	biological_process	regulation of organ growth
Y	0046688	biological_process	response to copper ion
Y	0046716	biological_process	muscle cell cellular homeostasis
Y	0046872	molecular_function	metal ion binding
Y	0048538	biological_process	thymus development
Y	0048678	biological_process	response to axon injury
Y	0050665	biological_process	hydrogen peroxide biosynthetic process
Y	0050728	biological_process	negative regulation of inflammatory response
Y	0050766	biological_process	positive regulation of phagocytosis
Y	0051087	molecular_function	protein-folding chaperone binding
Y	0051881	biological_process	regulation of mitochondrial membrane potential
Y	0060047	biological_process	heart contraction
Y	0060052	biological_process	neurofilament cytoskeleton organization
Y	0060087	biological_process	relaxation of vascular associated smooth muscle
Y	0060088	biological_process	auditory receptor cell stereocilium organization
Y	0070062	cellular_component	extracellular exosome
Y	0071276	biological_process	cellular response to cadmium ion
Y	0071318	biological_process	cellular response to ATP
Y	0072593	biological_process	reactive oxygen species metabolic process
Y	0097332	biological_process	response to antipsychotic drug
Y	1902177	biological_process	positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
Y	1904115	cellular_component	axon cytoplasm
Z	0000303	biological_process	response to superoxide
Z	0001541	biological_process	ovarian follicle development
Z	0001819	biological_process	positive regulation of cytokine production
Z	0001890	biological_process	placenta development
Z	0001895	biological_process	retina homeostasis
Z	0001975	biological_process	response to amphetamine
Z	0002262	biological_process	myeloid cell homeostasis
Z	0004784	molecular_function	superoxide dismutase activity
Z	0005507	molecular_function	copper ion binding
Z	0005515	molecular_function	protein binding
Z	0005576	cellular_component	extracellular region
Z	0005615	cellular_component	extracellular space
Z	0005634	cellular_component	nucleus
Z	0005654	cellular_component	nucleoplasm
Z	0005737	cellular_component	cytoplasm
Z	0005739	cellular_component	mitochondrion
Z	0005758	cellular_component	mitochondrial intermembrane space
Z	0005759	cellular_component	mitochondrial matrix
Z	0005764	cellular_component	lysosome
Z	0005777	cellular_component	peroxisome
Z	0005829	cellular_component	cytosol
Z	0005886	cellular_component	plasma membrane
Z	0006749	biological_process	glutathione metabolic process
Z	0006801	biological_process	superoxide metabolic process
Z	0006879	biological_process	intracellular iron ion homeostasis
Z	0006979	biological_process	response to oxidative stress
Z	0007283	biological_process	spermatogenesis
Z	0007566	biological_process	embryo implantation
Z	0007605	biological_process	sensory perception of sound
Z	0007626	biological_process	locomotory behavior
Z	0008089	biological_process	anterograde axonal transport
Z	0008090	biological_process	retrograde axonal transport
Z	0008217	biological_process	regulation of blood pressure
Z	0008270	molecular_function	zinc ion binding
Z	0009408	biological_process	response to heat
Z	0019226	biological_process	transmission of nerve impulse
Z	0019430	biological_process	removal of superoxide radicals
Z	0019899	molecular_function	enzyme binding
Z	0030141	cellular_component	secretory granule
Z	0030346	molecular_function	protein phosphatase 2B binding
Z	0031045	cellular_component	dense core granule
Z	0031267	molecular_function	small GTPase binding
Z	0031410	cellular_component	cytoplasmic vesicle
Z	0031667	biological_process	response to nutrient levels
Z	0032287	biological_process	peripheral nervous system myelin maintenance
Z	0032839	cellular_component	dendrite cytoplasm
Z	0032930	biological_process	positive regulation of superoxide anion generation
Z	0032991	cellular_component	protein-containing complex
Z	0033081	biological_process	regulation of T cell differentiation in thymus
Z	0034465	biological_process	response to carbon monoxide
Z	0034599	biological_process	cellular response to oxidative stress
Z	0035865	biological_process	cellular response to potassium ion
Z	0040014	biological_process	regulation of multicellular organism growth
Z	0042542	biological_process	response to hydrogen peroxide
Z	0042802	molecular_function	identical protein binding
Z	0042803	molecular_function	protein homodimerization activity
Z	0043025	cellular_component	neuronal cell body
Z	0043065	biological_process	positive regulation of apoptotic process
Z	0043066	biological_process	negative regulation of apoptotic process
Z	0043087	biological_process	regulation of GTPase activity
Z	0043410	biological_process	positive regulation of MAPK cascade
Z	0043524	biological_process	negative regulation of neuron apoptotic process
Z	0045471	biological_process	response to ethanol
Z	0046620	biological_process	regulation of organ growth
Z	0046688	biological_process	response to copper ion
Z	0046716	biological_process	muscle cell cellular homeostasis
Z	0046872	molecular_function	metal ion binding
Z	0048538	biological_process	thymus development
Z	0048678	biological_process	response to axon injury
Z	0050665	biological_process	hydrogen peroxide biosynthetic process
Z	0050728	biological_process	negative regulation of inflammatory response
Z	0050766	biological_process	positive regulation of phagocytosis
Z	0051087	molecular_function	protein-folding chaperone binding
Z	0051881	biological_process	regulation of mitochondrial membrane potential
Z	0060047	biological_process	heart contraction
Z	0060052	biological_process	neurofilament cytoskeleton organization
Z	0060087	biological_process	relaxation of vascular associated smooth muscle
Z	0060088	biological_process	auditory receptor cell stereocilium organization
Z	0070062	cellular_component	extracellular exosome
Z	0071276	biological_process	cellular response to cadmium ion
Z	0071318	biological_process	cellular response to ATP
Z	0072593	biological_process	reactive oxygen species metabolic process
Z	0097332	biological_process	response to antipsychotic drug
Z	1902177	biological_process	positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
Z	1904115	cellular_component	axon cytoplasm

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN W1154

Chain	Residue
W	HIS63
W	HIS80
W	ASP83
W	HOH2067

---

site_id	AC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 W1155

Chain	Residue
W	HIS63
W	HIS120
W	ARG143

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN X1154

Chain	Residue
X	ASP83
X	HOH2066
X	HIS63
X	HIS80

---

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 X1155

Chain	Residue
X	HIS48
X	HIS63
X	HIS120
X	ARG143
X	HOH2067

---

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN Y1154

Chain	Residue
Y	HIS63
Y	HIS80
Y	ASP83
Y	HOH2067

---

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 Y1155

Chain	Residue
Y	HIS48
Y	HIS63
Y	HIS120
Y	ARG143

---

site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN Z1154

Chain	Residue
Z	HIS63
Z	HIS80
Z	ASP83
Z	HOH2076

---

site_id	AC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 Z1155

Chain	Residue
Z	HIS63
Z	HIS120
Z	ARG143

---

Functional Information from PROSITE/UniProt

site_id	PS00332
Number of Residues	12
Details	SOD_CU_ZN_2 Copper/Zinc superoxide dismutase signature 2. GNAGsRlACgvI

Chain	Residue	Details
W	GLY138-ILE149

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PubMed","id":"12963370","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17548825","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PubMed","id":"20727846","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Modified residue: {"description":"N-acetylalanine","evidences":[{"source":"PubMed","id":"1463506","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7002610","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25944712","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	12
Details	Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"P08228","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P07632","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P08228","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	4
Details	Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"PubMed","id":"24140062","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	4
Details	Lipidation: {"description":"S-palmitoyl cysteine","evidences":[{"source":"PubMed","id":"22496122","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	8
Details	Cross-link: {"description":"1-(tryptophan-3-yl)-tryptophan (Trp-Trp) (interchain with W-33)","evidences":[{"source":"PubMed","id":"20600836","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 2jcw

Chain	Residue	Details
W	ARG143
W	HIS63

---

site_id	CSA2
Number of Residues	2
Details	Annotated By Reference To The Literature 2jcw

Chain	Residue	Details
X	ARG143
X	HIS63

---

site_id	CSA3
Number of Residues	2
Details	Annotated By Reference To The Literature 2jcw

Chain	Residue	Details
Y	ARG143
Y	HIS63

---

site_id	CSA4
Number of Residues	2
Details	Annotated By Reference To The Literature 2jcw

Chain	Residue	Details
Z	ARG143
Z	HIS63

---

site_id	CSA5
Number of Residues	1
Details	Annotated By Reference To The Literature 2jcw

Chain	Residue	Details
W	HIS63

---

site_id	CSA6
Number of Residues	1
Details	Annotated By Reference To The Literature 2jcw

Chain	Residue	Details
X	HIS63

---

site_id	CSA7
Number of Residues	1
Details	Annotated By Reference To The Literature 2jcw

Chain	Residue	Details
Y	HIS63

---

site_id	CSA8
Number of Residues	1
Details	Annotated By Reference To The Literature 2jcw

Chain	Residue	Details
Z	HIS63

---