1OCE
ACETYLCHOLINESTERASE (E.C. 3.1.1.7) COMPLEXED WITH MF268
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001507 | biological_process | acetylcholine catabolic process in synaptic cleft |
| A | 0003990 | molecular_function | acetylcholinesterase activity |
| A | 0004104 | molecular_function | cholinesterase activity |
| A | 0005615 | cellular_component | extracellular space |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006581 | biological_process | acetylcholine catabolic process |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0019695 | biological_process | choline metabolic process |
| A | 0043083 | cellular_component | synaptic cleft |
| A | 0045202 | cellular_component | synapse |
| A | 0052689 | molecular_function | carboxylic ester hydrolase activity |
| A | 0098552 | cellular_component | side of membrane |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE MF2 A 700 |
| Chain | Residue |
| A | PHE330 |
| A | PHE331 |
| A | TYR334 |
| A | HIS440 |
| A | TYR70 |
| A | GLY118 |
| A | GLY119 |
| A | TYR121 |
| A | SER200 |
| A | ALA201 |
| site_id | ACT |
| Number of Residues | 3 |
| Details | ACTIVE-SITE CATALYTIC TRIAD. |
| Chain | Residue |
| A | SER200 |
| A | HIS440 |
| A | GLU327 |
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Acyl-ester intermediate"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Charge relay system"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"10368299","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16763558","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"10368299","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16763558","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"1678899","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"10368299","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1qe3 |
| Chain | Residue | Details |
| A | SER200 | |
| A | HIS440 | |
| A | GLU327 |
