1OC5

D405N mutant of the CELLOBIOHYDROLASE CEL6A FROM HUMICOLA INSOLENS in complex with methyl-cellobiosyl-4-deoxy-4-thio-beta-D-cellobioside

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004553	molecular_function	hydrolase activity, hydrolyzing O-glycosyl compounds
A	0005975	biological_process	carbohydrate metabolic process
A	0030245	biological_process	cellulose catabolic process

Functional Information from PROSITE/UniProt

site_id	PS00655
Number of Residues	17
Details	GLYCOSYL_HYDROL_F6_1 Glycosyl hydrolases family 6 signature 1. VvYdlPdRDCAaaASnG

Chain	Residue	Details
A	VAL172-GLY188

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site_id	PS00656
Number of Residues	10
Details	GLYCOSYL_HYDROL_F6_2 Glycosyl hydrolases family 6 signature 2. ILVIEPDSLA

Chain	Residue	Details
A	ILE220-ALA229

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Proton donor => ECO:0000255|PROSITE-ProRule:PRU10057, ECO:0000269|PubMed:10413461, ECO:0000269|PubMed:12842048

Chain	Residue	Details
A	ASP226

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site_id	SWS_FT_FI2
Number of Residues	1
Details	ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU10056, ECO:0000269|PubMed:10413461, ECO:0000269|PubMed:12454501, ECO:0000269|PubMed:12842048

Chain	Residue	Details
A	ASN405

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site_id	SWS_FT_FI3
Number of Residues	8
Details	BINDING: BINDING => ECO:0000269|PubMed:10413461, ECO:0000269|PubMed:12454501, ECO:0000269|PubMed:12842048

Chain	Residue	Details
A	TRP137
A	ASP139
A	HIS271
A	TRP274
A	ASN310
A	TRP371
A	LYS399
A	GLU403

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site_id	SWS_FT_FI4
Number of Residues	1
Details	CARBOHYD: O-linked (Man...) threonine => ECO:0000269|PubMed:9882628

Chain	Residue	Details
A	THR118

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site_id	SWS_FT_FI5
Number of Residues	1
Details	CARBOHYD: O-linked (Man...) serine => ECO:0000269|PubMed:9882628

Chain	Residue	Details
A	SER127

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site_id	SWS_FT_FI6
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:10413461, ECO:0000269|PubMed:12454501, ECO:0000269|PubMed:12842048, ECO:0000269|PubMed:9882628

Chain	Residue	Details
A	ASN141

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	4
Details	Annotated By Reference To The Literature 1qk2

Chain	Residue	Details
A	ARG179
A	ASP226
A	ASP180
A	TYR174

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site_id	CSA2
Number of Residues	2
Details	Annotated By Reference To The Literature 1qk2

Chain	Residue	Details
A	ASP226
A	ASN405

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