1OBA

Multimodular Pneumococcal Cell Wall Endolysin from phage Cp-1 complexed with choline

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003796	molecular_function	lysozyme activity
A	0005515	molecular_function	protein binding
A	0009253	biological_process	peptidoglycan catabolic process
A	0016798	molecular_function	hydrolase activity, acting on glycosyl bonds
A	0016998	biological_process	cell wall macromolecule catabolic process
A	0031640	biological_process	killing of cells of another organism
A	0042742	biological_process	defense response to bacterium
A	0044659	biological_process	viral release from host cell by cytolysis

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CHT A1340

Chain	Residue
A	TRP223
A	TRP230
A	TYR252
A	SER277

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site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CHT A1341

Chain	Residue
A	TRP202
A	TRP209
A	TYR231
A	ASN257
A	HOH2257

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Functional Information from PROSITE/UniProt

site_id	PS00953
Number of Residues	34
Details	GLYCOSYL_HYDROL_F25_1 Glycosyl hydrolases family 25 active site signature. DVsshNGyditgileqm.....GttntIIKiSESttYlN

Chain	Residue	Details
A	ASP10-ASN43

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	ACT_SITE: ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU01252

Chain	Residue	Details
A	ASP10
A	ASP92
A	GLU94

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	4
Details	a catalytic site defined by CSA, PubMed 14527392

Chain	Residue	Details
A	ASP10
A	ASP182
A	ASP92
A	GLU94

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site_id	MCSA1
Number of Residues	4
Details	M-CSA 774

Chain	Residue	Details
A	ASP10	activator, electrostatic stabiliser, increase nucleophilicity, proton acceptor, proton donor
A	ASP92	proton donor
A	GLU94	activator, increase nucleophilicity, promote heterolysis, proton acceptor, proton donor
A	ASP182	proton acceptor

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