1OAO
NiZn[Fe4S4] and NiNi[Fe4S4] clusters in closed and open alpha subunits of acetyl-CoA synthase/carbon monoxide dehydrogenase
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0004601 | molecular_function | peroxidase activity |
| A | 0006091 | biological_process | generation of precursor metabolites and energy |
| A | 0015977 | biological_process | carbon fixation |
| A | 0016151 | molecular_function | nickel cation binding |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0042542 | biological_process | response to hydrogen peroxide |
| A | 0043885 | molecular_function | anaerobic carbon-monoxide dehydrogenase activity |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0050418 | molecular_function | hydroxylamine reductase activity |
| A | 0051539 | molecular_function | 4 iron, 4 sulfur cluster binding |
| A | 0098869 | biological_process | cellular oxidant detoxification |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0004601 | molecular_function | peroxidase activity |
| B | 0006091 | biological_process | generation of precursor metabolites and energy |
| B | 0015977 | biological_process | carbon fixation |
| B | 0016151 | molecular_function | nickel cation binding |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0042542 | biological_process | response to hydrogen peroxide |
| B | 0043885 | molecular_function | anaerobic carbon-monoxide dehydrogenase activity |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0050418 | molecular_function | hydroxylamine reductase activity |
| B | 0051539 | molecular_function | 4 iron, 4 sulfur cluster binding |
| B | 0098869 | biological_process | cellular oxidant detoxification |
| C | 0003824 | molecular_function | catalytic activity |
| C | 0006084 | biological_process | acetyl-CoA metabolic process |
| C | 0015977 | biological_process | carbon fixation |
| C | 0016491 | molecular_function | oxidoreductase activity |
| C | 0016740 | molecular_function | transferase activity |
| C | 0043884 | molecular_function | CO-methylating acetyl-CoA synthase activity |
| C | 0043885 | molecular_function | anaerobic carbon-monoxide dehydrogenase activity |
| C | 0046872 | molecular_function | metal ion binding |
| C | 0051539 | molecular_function | 4 iron, 4 sulfur cluster binding |
| D | 0003824 | molecular_function | catalytic activity |
| D | 0006084 | biological_process | acetyl-CoA metabolic process |
| D | 0015977 | biological_process | carbon fixation |
| D | 0016491 | molecular_function | oxidoreductase activity |
| D | 0016740 | molecular_function | transferase activity |
| D | 0043884 | molecular_function | CO-methylating acetyl-CoA synthase activity |
| D | 0043885 | molecular_function | anaerobic carbon-monoxide dehydrogenase activity |
| D | 0046872 | molecular_function | metal ion binding |
| D | 0051539 | molecular_function | 4 iron, 4 sulfur cluster binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 A1679 |
| Chain | Residue |
| A | PRO273 |
| A | LYS412 |
| A | PRO417 |
| A | VAL418 |
| A | HOH2322 |
| site_id | AC2 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE SO4 A1680 |
| Chain | Residue |
| A | LEU615 |
| A | HOH2323 |
| D | HIS27 |
| D | HOH2016 |
| A | ALA94 |
| A | TRP95 |
| A | SER613 |
| A | ASP614 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A1681 |
| Chain | Residue |
| A | PRO17 |
| A | ARG18 |
| A | VAL19 |
| A | HOH2027 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A1682 |
| Chain | Residue |
| A | ARG148 |
| A | GLU153 |
| A | VAL154 |
| A | GLU155 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 A1683 |
| Chain | Residue |
| A | ASN415 |
| A | HOH2324 |
| C | THR2 |
| C | ASP3 |
| C | HOH2001 |
| site_id | AC6 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 A1684 |
| Chain | Residue |
| A | LYS195 |
| A | ARG199 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 A1685 |
| Chain | Residue |
| A | THR399 |
| A | ARG402 |
| A | HOH2214 |
| A | HOH2325 |
| A | HOH2326 |
| site_id | AC8 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE SO4 A1686 |
| Chain | Residue |
| A | ARG402 |
| site_id | AC9 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 A1688 |
| Chain | Residue |
| A | LYS144 |
| A | ARG148 |
| site_id | BC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A1689 |
| Chain | Residue |
| A | ARG176 |
| A | GLU180 |
| A | HOH2123 |
| A | HOH2132 |
| site_id | BC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 A1690 |
| Chain | Residue |
| A | HIS119 |
| A | HIS122 |
| A | GLN389 |
| A | THR390 |
| A | HOH2330 |
| A | HOH2331 |
| site_id | BC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE FE2 A1700 |
| Chain | Residue |
| A | HIS283 |
| A | CYS317 |
| A | CYS550 |
| A | LYS587 |
| A | XCC1677 |
| site_id | BC4 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE SO4 B1679 |
| Chain | Residue |
| B | ALA94 |
| B | TRP95 |
| B | GLY612 |
| B | SER613 |
| B | ASP614 |
| B | LEU615 |
| B | HOH2340 |
| B | HOH2341 |
| B | HOH2342 |
| C | HIS27 |
| site_id | BC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 B1680 |
| Chain | Residue |
| B | ARG25 |
| B | ASP26 |
| B | LYS41 |
| B | HOH2343 |
| site_id | BC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 B1681 |
| Chain | Residue |
| B | PRO17 |
| B | ARG18 |
| B | VAL19 |
| B | HOH2029 |
| B | HOH2344 |
| site_id | BC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 B1682 |
| Chain | Residue |
| B | THR399 |
| B | ARG402 |
| B | HOH2346 |
| B | HOH2347 |
| D | HOH2241 |
| site_id | BC8 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 B1683 |
| Chain | Residue |
| B | LYS195 |
| B | ARG199 |
| B | HOH2348 |
| site_id | BC9 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE SO4 B1684 |
| Chain | Residue |
| B | ARG402 |
| site_id | CC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 B1685 |
| Chain | Residue |
| B | HIS119 |
| B | HIS122 |
| B | GLN389 |
| B | THR390 |
| B | HOH2349 |
| B | HOH2350 |
| B | HOH2351 |
| site_id | CC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 B1686 |
| Chain | Residue |
| B | LYS144 |
| B | ARG148 |
| B | HOH2352 |
| site_id | CC3 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE SO4 B1687 |
| Chain | Residue |
| B | ARG450 |
| site_id | CC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 B1688 |
| Chain | Residue |
| B | LYS44 |
| B | VAL45 |
| B | ILE46 |
| B | HOH2354 |
| B | HOH2355 |
| site_id | CC5 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE BCT B1691 |
| Chain | Residue |
| B | ASP522 |
| B | LYS525 |
| B | HOH2357 |
| B | ARG148 |
| B | GLU153 |
| B | VAL154 |
| B | GLU155 |
| site_id | CC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE FE2 B1700 |
| Chain | Residue |
| B | HIS283 |
| B | CYS317 |
| B | CYS550 |
| B | XCC1677 |
| site_id | CC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ZN C1731 |
| Chain | Residue |
| C | CYS509 |
| C | CYS595 |
| C | CYS597 |
| C | NI1732 |
| C | SX1733 |
| site_id | CC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE NI C1732 |
| Chain | Residue |
| C | CYS595 |
| C | GLY596 |
| C | CYS597 |
| C | ZN1731 |
| site_id | CC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 C1734 |
| Chain | Residue |
| C | ASP617 |
| C | HIS618 |
| C | ALA619 |
| C | GLY620 |
| C | HOH2336 |
| site_id | DC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 C1735 |
| Chain | Residue |
| C | ARG143 |
| C | ARG616 |
| C | ASP617 |
| C | ARG649 |
| site_id | DC2 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 C1736 |
| Chain | Residue |
| C | TYR572 |
| C | ARG577 |
| site_id | DC3 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE SO4 C1738 |
| Chain | Residue |
| C | ARG85 |
| C | LYS86 |
| C | GLN89 |
| C | ARG237 |
| C | HOH2065 |
| C | HOH2094 |
| C | HOH2337 |
| C | HOH2338 |
| site_id | DC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 C1740 |
| Chain | Residue |
| C | GLU17 |
| C | ASN95 |
| C | PHE96 |
| C | GLU97 |
| C | GOL1741 |
| C | HOH2341 |
| site_id | DC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 C1742 |
| Chain | Residue |
| B | GLY300 |
| C | ARG334 |
| C | LYS335 |
| C | ARG429 |
| site_id | DC6 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE NI D1731 |
| Chain | Residue |
| D | CYS509 |
| D | PHE512 |
| D | CYS595 |
| D | CYS597 |
| D | SF41730 |
| D | NI1732 |
| D | ACT1733 |
| site_id | DC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE NI D1732 |
| Chain | Residue |
| D | CYS595 |
| D | GLY596 |
| D | CYS597 |
| D | NI1731 |
| site_id | DC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ACT D1733 |
| Chain | Residue |
| D | CYS509 |
| D | CYS528 |
| D | CYS597 |
| D | SF41730 |
| D | NI1731 |
| site_id | DC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 D1734 |
| Chain | Residue |
| D | ASP617 |
| D | HIS618 |
| D | ALA619 |
| D | GLY620 |
| site_id | EC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 D1735 |
| Chain | Residue |
| D | ARG85 |
| D | LYS86 |
| D | GLN89 |
| D | ARG237 |
| D | HOH2037 |
| D | HOH2065 |
| D | HOH2239 |
| site_id | EC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 D1737 |
| Chain | Residue |
| D | THR615 |
| D | ASP617 |
| D | ARG649 |
| D | SER673 |
| D | LEU674 |
| D | HOH2242 |
| site_id | EC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 D1738 |
| Chain | Residue |
| D | VAL500 |
| D | ASP501 |
| D | THR502 |
| D | TRP533 |
| D | LYS537 |
| site_id | EC4 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE SF4 A1676 |
| Chain | Residue |
| A | CYS68 |
| A | CYS71 |
| A | GLY74 |
| A | CYS76 |
| A | GLY88 |
| A | CYS90 |
| A | ARG100 |
| A | MET221 |
| site_id | EC5 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE XCC A1677 |
| Chain | Residue |
| A | HIS283 |
| A | CYS316 |
| A | CYS317 |
| A | PHE334 |
| A | CYS355 |
| A | GLY469 |
| A | CYS470 |
| A | CYS500 |
| A | CYS550 |
| A | SER585 |
| A | LYS587 |
| A | FOR1678 |
| A | FE21700 |
| site_id | EC6 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE SF4 B1675 |
| Chain | Residue |
| A | CYS59 |
| A | GLY62 |
| A | CYS67 |
| A | ARG69 |
| B | CYS59 |
| B | GLY62 |
| B | CYS67 |
| B | ARG69 |
| site_id | EC7 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE SF4 B1676 |
| Chain | Residue |
| B | CYS68 |
| B | CYS71 |
| B | GLY74 |
| B | CYS76 |
| B | GLY88 |
| B | CYS90 |
| B | ARG100 |
| B | MET221 |
| site_id | EC8 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE XCC B1677 |
| Chain | Residue |
| B | HIS283 |
| B | CYS316 |
| B | CYS317 |
| B | PHE334 |
| B | CYS355 |
| B | GLY469 |
| B | CYS470 |
| B | CYS500 |
| B | CYS550 |
| B | SER585 |
| B | LYS587 |
| B | FOR1678 |
| B | FE21700 |
| site_id | EC9 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE SF4 C1730 |
| Chain | Residue |
| C | ILE146 |
| C | CYS506 |
| C | CYS509 |
| C | CYS518 |
| C | GLY526 |
| C | LEU527 |
| C | CYS528 |
| C | VAL531 |
| C | CYS597 |
| site_id | FC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SX C1733 |
| Chain | Residue |
| C | VAL149 |
| C | PHE229 |
| C | CYS595 |
| C | CYS597 |
| C | ZN1731 |
| site_id | FC2 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE SF4 D1730 |
| Chain | Residue |
| D | CYS506 |
| D | CYS509 |
| D | CYS518 |
| D | LEU527 |
| D | CYS528 |
| D | CYS595 |
| D | CYS597 |
| D | NI1731 |
| D | ACT1733 |
| site_id | FC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE FOR A1678 |
| Chain | Residue |
| A | GLY469 |
| A | CYS550 |
| A | ILE591 |
| A | XCC1677 |
| site_id | FC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE FOR B1678 |
| Chain | Residue |
| B | GLY469 |
| B | CYS550 |
| B | ALA588 |
| B | ILE591 |
| B | XCC1677 |
| site_id | FC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL A1687 |
| Chain | Residue |
| A | VAL45 |
| A | ILE46 |
| A | ALA362 |
| A | HOH2327 |
| A | HOH2328 |
| A | HOH2329 |
| site_id | FC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL B1689 |
| Chain | Residue |
| B | ASN479 |
| B | LEU482 |
| B | THR483 |
| B | LYS486 |
| B | HOH2356 |
| site_id | FC7 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE GOL B1690 |
| Chain | Residue |
| B | VAL45 |
| B | ASP50 |
| site_id | FC8 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE GOL C1737 |
| Chain | Residue |
| C | GLU554 |
| C | GLY555 |
| C | GLU556 |
| site_id | FC9 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GOL C1739 |
| Chain | Residue |
| C | ALA59 |
| C | TYR60 |
| C | TYR61 |
| C | ARG66 |
| C | GLY633 |
| C | MET634 |
| C | HOH2339 |
| C | HOH2340 |
| site_id | GC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL C1741 |
| Chain | Residue |
| C | MET1 |
| C | ASP5 |
| C | PHE8 |
| C | GLU9 |
| C | GLU97 |
| C | ARG100 |
| C | SO41740 |
| site_id | GC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL C1743 |
| Chain | Residue |
| C | VAL500 |
| C | ASP501 |
| C | THR502 |
| C | TYR504 |
| C | TRP533 |
| C | LYS537 |
| site_id | GC3 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL D1736 |
| Chain | Residue |
| B | ILE386 |
| B | THR399 |
| B | MET403 |
| D | PRO81 |
| D | ASN84 |
| D | HOH2240 |
| D | HOH2241 |
Functional Information from PROSITE/UniProt
| site_id | PS00216 |
| Number of Residues | 18 |
| Details | SUGAR_TRANSPORT_1 Sugar transport proteins signature 1. LGILVDIYGRKmqadfeG |
| Chain | Residue | Details |
| C | LEU384-GLY401 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 14 |
| Details | BINDING: |
| Chain | Residue | Details |
| C | CYS506 | |
| D | CYS518 | |
| D | CYS528 | |
| D | CYS595 | |
| D | GLY596 | |
| D | CYS597 | |
| B | CYS68 | |
| B | CYS71 | |
| B | CYS76 | |
| B | CYS90 | |
| B | HIS283 | |
| C | CYS509 | |
| B | CYS317 | |
| B | CYS355 | |
| B | CYS470 | |
| B | CYS500 | |
| B | CYS550 | |
| C | CYS518 | |
| C | CYS528 | |
| C | CYS595 | |
| C | GLY596 | |
| C | CYS597 | |
| D | CYS506 | |
| D | CYS509 |
