1OAA
MOUSE SEPIAPTERIN REDUCTASE COMPLEXED WITH NADP AND OXALOACETATE
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004757 | molecular_function | sepiapterin reductase (NADP+) activity |
| A | 0005654 | cellular_component | nucleoplasm |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0005829 | cellular_component | cytosol |
| A | 0006558 | biological_process | L-phenylalanine metabolic process |
| A | 0006729 | biological_process | tetrahydrobiopterin biosynthetic process |
| A | 0006809 | biological_process | nitric oxide biosynthetic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0019889 | biological_process | pteridine metabolic process |
| A | 0040014 | biological_process | regulation of multicellular organism growth |
| A | 0042415 | biological_process | norepinephrine metabolic process |
| A | 0042417 | biological_process | dopamine metabolic process |
| A | 0042428 | biological_process | serotonin metabolic process |
| A | 0042803 | molecular_function | protein homodimerization activity |
| A | 0046146 | biological_process | tetrahydrobiopterin metabolic process |
| A | 0048667 | biological_process | cell morphogenesis involved in neuron differentiation |
| A | 0050882 | biological_process | voluntary musculoskeletal movement |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE SO4 A 801 |
| Chain | Residue |
| A | LYS215 |
| A | LYS215 |
| A | PRO217 |
| A | ARG220 |
| A | ARG220 |
| A | HOH862 |
| A | HOH862 |
| A | HOH1251 |
| site_id | AC2 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE SO4 A 802 |
| Chain | Residue |
| A | ASP70 |
| A | THR73 |
| A | GLY76 |
| A | ARG79 |
| A | HOH1070 |
| A | HOH1207 |
| A | HOH1213 |
| A | ALA69 |
| site_id | AC3 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE OAA A 1 |
| Chain | Residue |
| A | LEU105 |
| A | SER158 |
| A | TYR171 |
| A | MET206 |
| A | GLN207 |
| A | ALA210 |
| A | NAP800 |
| A | HOH844 |
| A | HOH973 |
| A | HOH1154 |
| site_id | AC4 |
| Number of Residues | 36 |
| Details | BINDING SITE FOR RESIDUE NAP A 800 |
| Chain | Residue |
| A | OAA1 |
| A | GLY15 |
| A | SER17 |
| A | ARG18 |
| A | GLY19 |
| A | PHE20 |
| A | ALA42 |
| A | ARG43 |
| A | SER44 |
| A | ALA69 |
| A | ASP70 |
| A | LEU71 |
| A | ASN101 |
| A | ALA102 |
| A | ALA103 |
| A | LEU127 |
| A | ILE156 |
| A | SER157 |
| A | TYR171 |
| A | LYS175 |
| A | PRO199 |
| A | GLY200 |
| A | LEU202 |
| A | ASN204 |
| A | ASP205 |
| A | MET206 |
| A | GLN207 |
| A | HOH814 |
| A | HOH815 |
| A | HOH826 |
| A | HOH869 |
| A | HOH883 |
| A | HOH891 |
| A | HOH913 |
| A | HOH1006 |
| A | HOH1019 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 19 |
| Details | Binding site: {} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 3 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P18297","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P35270","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1ybv |
| Chain | Residue | Details |
| A | LYS175 | |
| A | SER158 | |
| A | TYR171 | |
| A | ASN128 |
| site_id | CSA2 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1ybv |
| Chain | Residue | Details |
| A | LYS175 | |
| A | TRP168 |
| site_id | CSA3 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1ybv |
| Chain | Residue | Details |
| A | LYS175 | |
| A | TYR171 |
