1O94
Ternary complex between trimethylamine dehydrogenase and electron transferring flavoprotein
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0009056 | biological_process | catabolic process |
| A | 0010181 | molecular_function | FMN binding |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0050470 | molecular_function | trimethylamine dehydrogenase activity |
| A | 0051539 | molecular_function | 4 iron, 4 sulfur cluster binding |
| B | 0009056 | biological_process | catabolic process |
| B | 0010181 | molecular_function | FMN binding |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0050470 | molecular_function | trimethylamine dehydrogenase activity |
| B | 0051539 | molecular_function | 4 iron, 4 sulfur cluster binding |
| C | 0000166 | molecular_function | nucleotide binding |
| C | 0009055 | molecular_function | electron transfer activity |
| D | 0009055 | molecular_function | electron transfer activity |
| D | 0033539 | biological_process | fatty acid beta-oxidation using acyl-CoA dehydrogenase |
| D | 0050660 | molecular_function | flavin adenine dinucleotide binding |
| E | 0000166 | molecular_function | nucleotide binding |
| E | 0009055 | molecular_function | electron transfer activity |
| F | 0009055 | molecular_function | electron transfer activity |
| F | 0033539 | biological_process | fatty acid beta-oxidation using acyl-CoA dehydrogenase |
| F | 0050660 | molecular_function | flavin adenine dinucleotide binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 22 |
| Details | BINDING SITE FOR RESIDUE FMN A 1730 |
| Chain | Residue |
| A | VAL27 |
| A | ARG222 |
| A | TRP264 |
| A | ASP267 |
| A | VAL297 |
| A | ARG299 |
| A | CYS320 |
| A | ALA321 |
| A | ARG322 |
| A | PRO323 |
| A | ILE352 |
| A | PRO28 |
| A | HOH2712 |
| A | HOH2714 |
| A | HOH2715 |
| A | HIS29 |
| A | CYS30 |
| A | GLU59 |
| A | TYR60 |
| A | GLU103 |
| A | TYR169 |
| A | HIS172 |
| site_id | AC2 |
| Number of Residues | 21 |
| Details | BINDING SITE FOR RESIDUE ADP A 1731 |
| Chain | Residue |
| A | VAL395 |
| A | GLY396 |
| A | GLY398 |
| A | PRO399 |
| A | SER400 |
| A | ASP419 |
| A | THR420 |
| A | GLY426 |
| A | HIS427 |
| A | PRO469 |
| A | MET470 |
| A | ALA486 |
| A | THR487 |
| A | GLY488 |
| A | GLY673 |
| A | ASP674 |
| A | HOH2402 |
| A | HOH2488 |
| A | HOH2716 |
| A | HOH2717 |
| A | HOH2718 |
| site_id | AC3 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE SF4 A 1732 |
| Chain | Residue |
| A | ARG322 |
| A | ILE325 |
| A | CYS345 |
| A | ILE346 |
| A | GLY347 |
| A | CYS348 |
| A | ASN349 |
| A | CYS351 |
| A | CYS364 |
| A | THR365 |
| site_id | AC4 |
| Number of Residues | 23 |
| Details | BINDING SITE FOR RESIDUE FMN B 1730 |
| Chain | Residue |
| B | VAL27 |
| B | PRO28 |
| B | HIS29 |
| B | CYS30 |
| B | GLU59 |
| B | TYR60 |
| B | GLU103 |
| B | TYR169 |
| B | HIS172 |
| B | ARG222 |
| B | TRP264 |
| B | ASP267 |
| B | ALA268 |
| B | VAL297 |
| B | ARG299 |
| B | CYS320 |
| B | ALA321 |
| B | ARG322 |
| B | PRO323 |
| B | ILE352 |
| B | HOH2388 |
| B | HOH2823 |
| B | HOH2824 |
| site_id | AC5 |
| Number of Residues | 22 |
| Details | BINDING SITE FOR RESIDUE ADP B 1731 |
| Chain | Residue |
| B | VAL395 |
| B | GLY396 |
| B | GLY398 |
| B | PRO399 |
| B | SER400 |
| B | ASP419 |
| B | THR420 |
| B | GLY426 |
| B | HIS427 |
| B | PRO469 |
| B | MET470 |
| B | ALA486 |
| B | THR487 |
| B | GLY488 |
| B | GLY673 |
| B | ASP674 |
| B | HOH2825 |
| B | HOH2826 |
| B | HOH2827 |
| B | HOH2828 |
| B | HOH2829 |
| B | HOH2830 |
| site_id | AC6 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE SF4 B 1732 |
| Chain | Residue |
| B | ILE325 |
| B | CYS345 |
| B | CYS348 |
| B | ASN349 |
| B | CYS351 |
| B | CYS364 |
| B | THR365 |
| B | ARG322 |
| site_id | AC7 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR RESIDUE AMP C 1236 |
| Chain | Residue |
| C | ALA6 |
| C | VAL7 |
| C | LYS8 |
| C | ASN36 |
| C | ASP39 |
| C | VAL62 |
| C | SER63 |
| C | VAL64 |
| C | ALA118 |
| C | GLY119 |
| C | GLN121 |
| C | SER122 |
| C | TYR127 |
| C | ALA128 |
| C | SER129 |
| C | THR130 |
| C | HOH2113 |
| C | HOH2114 |
| C | HOH2177 |
| C | HOH2178 |
| site_id | AC8 |
| Number of Residues | 21 |
| Details | BINDING SITE FOR RESIDUE AMP E 1237 |
| Chain | Residue |
| E | ALA6 |
| E | VAL7 |
| E | LYS8 |
| E | ASN36 |
| E | ASP39 |
| E | VAL62 |
| E | SER63 |
| E | VAL64 |
| E | VAL100 |
| E | ALA118 |
| E | GLY119 |
| E | GLN121 |
| E | SER122 |
| E | TYR127 |
| E | ALA128 |
| E | SER129 |
| E | THR130 |
| E | HOH2117 |
| E | HOH2126 |
| E | HOH2197 |
| E | HOH2198 |
Functional Information from PROSITE/UniProt
| site_id | PS00696 |
| Number of Residues | 27 |
| Details | ETF_ALPHA Electron transfer flavoprotein alpha-subunit signature. LYVAmGISGsIQHmaGmkhvptIiAVN |
| Chain | Residue | Details |
| D | LEU262-ASN288 |
| site_id | PS01065 |
| Number of Residues | 22 |
| Details | ETF_BETA Electron transfer flavoprotein beta-subunit signature. IrRelEGGmlQeVeincPaVLT |
| Chain | Residue | Details |
| C | ILE160-THR181 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: Proton donor => ECO:0000250 |
| Chain | Residue | Details |
| A | LEU175 | |
| F | ILE268 | |
| F | THR289 | |
| F | ILE307 | |
| B | LEU175 | |
| D | VAL250 | |
| D | ILE268 | |
| D | THR289 | |
| D | ILE307 | |
| F | GLY211 | |
| F | ARG236 | |
| F | VAL250 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 16 |
| Details | BINDING: |
| Chain | Residue | Details |
| A | LEU104 | |
| B | PHE223 | |
| B | ALA268 | |
| B | PRO323 | |
| B | ILE346 | |
| B | ASN349 | |
| B | ILE352 | |
| B | THR365 | |
| A | PHE223 | |
| A | ALA268 | |
| A | PRO323 | |
| A | ILE346 | |
| A | ASN349 | |
| A | ILE352 | |
| A | THR365 | |
| B | LEU104 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000250 |
| Chain | Residue | Details |
| A | GLY170 | |
| A | VAL392 | |
| B | GLY170 | |
| B | VAL392 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | MOD_RES: S-6-FMN cysteine |
| Chain | Residue | Details |
| A | ILE31 | |
| B | ILE31 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1ps9 |
| Chain | Residue | Details |
| A | TYR174 | |
| A | ASP260 |
| site_id | CSA2 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1ps9 |
| Chain | Residue | Details |
| B | TYR174 | |
| B | ASP260 |
| site_id | CSA3 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1ps9 |
| Chain | Residue | Details |
| A | HIS172 | |
| A | TYR169 | |
| A | ASP267 |
| site_id | CSA4 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1ps9 |
| Chain | Residue | Details |
| B | HIS172 | |
| B | TYR169 | |
| B | ASP267 |
| site_id | MCSA1 |
| Number of Residues | 4 |
| Details | M-CSA 114 |
| Chain | Residue | Details |
| A | ILE31 | activator, alter redox potential, covalently attached |
| A | GLY170 | activator, alter redox potential, electrostatic stabiliser, hydrogen bond donor |
| A | SER173 | activator, electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor |
| A | ALA268 | electrostatic stabiliser |
| site_id | MCSA2 |
| Number of Residues | 4 |
| Details | M-CSA 114 |
| Chain | Residue | Details |
| B | ILE31 | activator, alter redox potential, covalently attached |
| B | GLY170 | activator, alter redox potential, electrostatic stabiliser, hydrogen bond donor |
| B | SER173 | activator, electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor |
| B | ALA268 | electrostatic stabiliser |
