1O71
Crystal structure of the water-soluble state of the pore-forming cytolysin Sticholysin II complexed with glycerol
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005576 | cellular_component | extracellular region |
| A | 0006811 | biological_process | monoatomic ion transport |
| A | 0006812 | biological_process | monoatomic cation transport |
| A | 0015267 | molecular_function | channel activity |
| A | 0016020 | cellular_component | membrane |
| A | 0031640 | biological_process | killing of cells of another organism |
| A | 0035821 | biological_process | modulation of process of another organism |
| A | 0042151 | cellular_component | nematocyst |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0044218 | cellular_component | other organism cell membrane |
| A | 0046930 | cellular_component | pore complex |
| A | 0046931 | biological_process | pore complex assembly |
| A | 0051715 | biological_process | cytolysis in another organism |
| A | 0055085 | biological_process | transmembrane transport |
| A | 0090729 | molecular_function | toxin activity |
| B | 0005576 | cellular_component | extracellular region |
| B | 0006811 | biological_process | monoatomic ion transport |
| B | 0006812 | biological_process | monoatomic cation transport |
| B | 0015267 | molecular_function | channel activity |
| B | 0016020 | cellular_component | membrane |
| B | 0031640 | biological_process | killing of cells of another organism |
| B | 0035821 | biological_process | modulation of process of another organism |
| B | 0042151 | cellular_component | nematocyst |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0044218 | cellular_component | other organism cell membrane |
| B | 0046930 | cellular_component | pore complex |
| B | 0046931 | biological_process | pore complex assembly |
| B | 0051715 | biological_process | cytolysis in another organism |
| B | 0055085 | biological_process | transmembrane transport |
| B | 0090729 | molecular_function | toxin activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE GOL A1176 |
| Chain | Residue |
| A | TYR111 |
| A | TYR136 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE GOL A1177 |
| Chain | Residue |
| A | ARG29 |
| A | HOH2011 |
| A | HOH2072 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL A1178 |
| Chain | Residue |
| A | PHE106 |
| A | ASP107 |
| A | SER52 |
| A | THR82 |
| A | GLY83 |
| A | PRO105 |
| site_id | AC4 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE GOL B1176 |
| Chain | Residue |
| B | TYR111 |
| B | TYR136 |
| site_id | AC5 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL B1177 |
| Chain | Residue |
| B | SER28 |
| B | ARG29 |
| B | PHE106 |
| B | HOH2067 |
| B | HOH2068 |
| B | HOH2069 |
| B | HOH2070 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL B1178 |
| Chain | Residue |
| B | SER52 |
| B | ALA81 |
| B | THR82 |
| B | GLY83 |
| B | PRO105 |
| B | PHE106 |
| B | ASP107 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 14 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:14604522 |
| Chain | Residue | Details |
| A | SER52 | |
| B | SER103 | |
| B | PRO105 | |
| B | TYR131 | |
| B | TYR135 | |
| B | TYR136 | |
| A | VAL85 | |
| A | SER103 | |
| A | PRO105 | |
| A | TYR131 | |
| A | TYR135 | |
| A | TYR136 | |
| B | SER52 | |
| B | VAL85 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | SITE: Important in the initial contact with the lipid membrane => ECO:0000250|UniProtKB:P61914 |
| Chain | Residue | Details |
| A | TRP110 | |
| A | TYR111 | |
| B | TRP110 | |
| B | TYR111 |
