1O6Y
Catalytic domain of PknB kinase from Mycobacterium tuberculosis
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG A 1280 |
| Chain | Residue |
| A | ASN143 |
| A | ASP156 |
| A | ACP1279 |
| A | HOH2079 |
| A | HOH2080 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG A 1281 |
| Chain | Residue |
| A | HOH2081 |
| A | HOH2082 |
| A | LYS40 |
| A | ACP1279 |
| A | HOH2054 |
| A | HOH2055 |
| site_id | AC3 |
| Number of Residues | 24 |
| Details | BINDING SITE FOR RESIDUE ACP A 1279 |
| Chain | Residue |
| A | GLY18 |
| A | GLY20 |
| A | GLY21 |
| A | MET22 |
| A | SER23 |
| A | ALA38 |
| A | LYS40 |
| A | VAL72 |
| A | GLU93 |
| A | VAL95 |
| A | THR99 |
| A | ALA142 |
| A | ASN143 |
| A | ASP156 |
| A | MG1280 |
| A | MG1281 |
| A | HOH2054 |
| A | HOH2055 |
| A | HOH2079 |
| A | HOH2080 |
| A | HOH2081 |
| A | HOH2082 |
| A | HOH2083 |
| A | HOH2084 |
Functional Information from PROSITE/UniProt
| site_id | PS00107 |
| Number of Residues | 24 |
| Details | PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGFGGMSEVHlArdlrlhrd..........VAVK |
| Chain | Residue | Details |
| A | LEU17-LYS40 |
| site_id | PS00108 |
| Number of Residues | 13 |
| Details | PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IiHrDVKpaNIMI |
| Chain | Residue | Details |
| A | ILE134-ILE146 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Proton acceptor"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 14 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"12548283","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12551895","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Binding site: {} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1ir3 |
| Chain | Residue | Details |
| A | ALA142 | |
| A | ASP138 |
| site_id | CSA2 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1ir3 |
| Chain | Residue | Details |
| A | ASP138 | |
| A | LYS140 |
| site_id | CSA3 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1ir3 |
| Chain | Residue | Details |
| A | ASP138 | |
| A | ASN143 | |
| A | LYS140 |
