1O66

Crystal structure of 3-methyl-2-oxobutanoate hydroxymethyltransferase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000287	molecular_function	magnesium ion binding
A	0003824	molecular_function	catalytic activity
A	0003864	molecular_function	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
A	0005737	cellular_component	cytoplasm
A	0015940	biological_process	pantothenate biosynthetic process
A	0016740	molecular_function	transferase activity
A	0046872	molecular_function	metal ion binding
B	0000287	molecular_function	magnesium ion binding
B	0003824	molecular_function	catalytic activity
B	0003864	molecular_function	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
B	0005737	cellular_component	cytoplasm
B	0015940	biological_process	pantothenate biosynthetic process
B	0016740	molecular_function	transferase activity
B	0046872	molecular_function	metal ion binding
C	0000287	molecular_function	magnesium ion binding
C	0003824	molecular_function	catalytic activity
C	0003864	molecular_function	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
C	0005737	cellular_component	cytoplasm
C	0015940	biological_process	pantothenate biosynthetic process
C	0016740	molecular_function	transferase activity
C	0046872	molecular_function	metal ion binding
D	0000287	molecular_function	magnesium ion binding
D	0003824	molecular_function	catalytic activity
D	0003864	molecular_function	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
D	0005737	cellular_component	cytoplasm
D	0015940	biological_process	pantothenate biosynthetic process
D	0016740	molecular_function	transferase activity
D	0046872	molecular_function	metal ion binding
E	0000287	molecular_function	magnesium ion binding
E	0003824	molecular_function	catalytic activity
E	0003864	molecular_function	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
E	0005737	cellular_component	cytoplasm
E	0015940	biological_process	pantothenate biosynthetic process
E	0016740	molecular_function	transferase activity
E	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL A 274

Chain	Residue
A	ARG61
A	ASP62
B	ARG61
B	ASP62
B	GOL274

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site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL C 274

Chain	Residue
D	GOL274
C	ARG61
C	ASP62
D	ARG61
D	ASP62

---

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL B 274

Chain	Residue
A	ARG61
A	ASP62
A	GOL274
B	ARG61
B	ASP62

---

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL D 274

Chain	Residue
C	ARG61
C	ASP62
C	GOL274
D	ARG61
D	ASP62

---

site_id	AC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL E 274

Chain	Residue
E	ARG61
E	ARG61
E	ASP62
E	ASP62
E	TYR65

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	5
Details	ACT_SITE: Proton acceptor => ECO:0000255|HAMAP-Rule:MF_00156

Chain	Residue	Details
A	GLU179
B	GLU179
C	GLU179
D	GLU179
E	GLU179

---

site_id	SWS_FT_FI2
Number of Residues	15
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00156

Chain	Residue	Details
A	ASP43
A	ASP82
A	GLU113
B	ASP43
B	ASP82
B	GLU113
C	ASP43
C	ASP82
C	GLU113
D	ASP43
D	ASP82
D	GLU113
E	ASP43
E	ASP82
E	GLU113

---

site_id	SWS_FT_FI3
Number of Residues	5
Details	BINDING:

Chain	Residue	Details
A	LYS111
B	LYS111
C	LYS111
D	LYS111
E	LYS111

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