1O5O

Crystal structure of Uracil phosphoribosyltransferase (TM0721) from Thermotoga maritima at 2.30 A resolution

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0000287	molecular_function	magnesium ion binding
A	0003824	molecular_function	catalytic activity
A	0004845	molecular_function	uracil phosphoribosyltransferase activity
A	0005525	molecular_function	GTP binding
A	0005737	cellular_component	cytoplasm
A	0006223	biological_process	uracil salvage
A	0016740	molecular_function	transferase activity
A	0016757	molecular_function	glycosyltransferase activity
A	0044206	biological_process	UMP salvage
B	0000166	molecular_function	nucleotide binding
B	0000287	molecular_function	magnesium ion binding
B	0003824	molecular_function	catalytic activity
B	0004845	molecular_function	uracil phosphoribosyltransferase activity
B	0005525	molecular_function	GTP binding
B	0005737	cellular_component	cytoplasm
B	0006223	biological_process	uracil salvage
B	0016740	molecular_function	transferase activity
B	0016757	molecular_function	glycosyltransferase activity
B	0044206	biological_process	UMP salvage
C	0000166	molecular_function	nucleotide binding
C	0000287	molecular_function	magnesium ion binding
C	0003824	molecular_function	catalytic activity
C	0004845	molecular_function	uracil phosphoribosyltransferase activity
C	0005525	molecular_function	GTP binding
C	0005737	cellular_component	cytoplasm
C	0006223	biological_process	uracil salvage
C	0016740	molecular_function	transferase activity
C	0016757	molecular_function	glycosyltransferase activity
C	0044206	biological_process	UMP salvage
D	0000166	molecular_function	nucleotide binding
D	0000287	molecular_function	magnesium ion binding
D	0003824	molecular_function	catalytic activity
D	0004845	molecular_function	uracil phosphoribosyltransferase activity
D	0005525	molecular_function	GTP binding
D	0005737	cellular_component	cytoplasm
D	0006223	biological_process	uracil salvage
D	0016740	molecular_function	transferase activity
D	0016757	molecular_function	glycosyltransferase activity
D	0044206	biological_process	UMP salvage

Functional Information from PDB Data

site_id	AC1
Number of Residues	10
Details	BINDING SITE FOR RESIDUE SO4 A 701

Chain	Residue
A	LEU78
D	TYR115
A	ARG79
A	ALA80
A	ILE102
A	U5P600
A	HOH753
A	HOH754
A	HOH756
A	HOH757

---

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 B 702

Chain	Residue
B	LEU78
B	ARG79
B	ALA80
B	U5P601
B	HOH768
C	TYR115

---

site_id	AC3
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 C 703

Chain	Residue
B	TYR115
C	LEU78
C	ARG79
C	ALA80
C	U5P602
C	HOH772
C	HOH773
C	HOH788

---

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 D 704

Chain	Residue
A	TYR115
D	ARG79
D	ALA80
D	U5P603
D	HOH794

---

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 705

Chain	Residue
A	ARG187
A	ASN189
A	ASP190
A	HOH710

---

site_id	AC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 B 706

Chain	Residue
B	ARG187
B	ASN189
B	ASP190

---

site_id	AC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 D 708

Chain	Residue
D	ARG187
D	ASN189
D	ASP190

---

site_id	AC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 A 709

Chain	Residue
A	GLY25
A	PRO26
A	ARG207
A	HOH748
A	HOH759
D	LYS70

---

site_id	AC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 D 710

Chain	Residue
A	LYS70
D	GLY25
D	PRO26
D	ARG207
D	HOH729

---

site_id	BC1
Number of Residues	19
Details	BINDING SITE FOR RESIDUE U5P A 600

Chain	Residue
A	ARG104
A	MET133
A	ALA135
A	THR136
A	GLY137
A	VAL138
A	SER139
A	GLY192
A	TYR193
A	ILE194
A	GLY199
A	ASP200
A	ALA201
A	SO4701
A	HOH712
A	HOH737
A	HOH754
A	HOH755
A	HOH756

---

site_id	BC2
Number of Residues	18
Details	BINDING SITE FOR RESIDUE U5P B 601

Chain	Residue
B	ARG104
B	ASP131
B	MET133
B	ALA135
B	THR136
B	GLY137
B	VAL138
B	SER139
B	GLY192
B	TYR193
B	ILE194
B	GLY199
B	ALA201
B	SO4702
B	HOH707
B	HOH724
B	HOH768
B	HOH774

---

site_id	BC3
Number of Residues	19
Details	BINDING SITE FOR RESIDUE U5P C 602

Chain	Residue
C	ALA201
C	SO4703
C	HOH705
C	HOH707
C	HOH710
C	HOH774
C	HOH788
C	ARG104
C	MET133
C	ALA135
C	THR136
C	GLY137
C	VAL138
C	SER139
C	GLY192
C	TYR193
C	ILE194
C	GLY199
C	ASP200

---

site_id	BC4
Number of Residues	17
Details	BINDING SITE FOR RESIDUE U5P D 603

Chain	Residue
D	ARG104
D	MET133
D	ALA135
D	THR136
D	GLY137
D	VAL138
D	SER139
D	GLY192
D	TYR193
D	ILE194
D	GLY199
D	ASP200
D	ALA201
D	SO4704
D	HOH719
D	HOH733
D	HOH794

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	56
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01218","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	3
Details	Annotated By Reference To The Literature 1bd3

Chain	Residue	Details
A	ARG104
A	ASP200
A	THR108

---

site_id	CSA2
Number of Residues	3
Details	Annotated By Reference To The Literature 1bd3

Chain	Residue	Details
B	ARG104
B	ASP200
B	THR108

---

site_id	CSA3
Number of Residues	3
Details	Annotated By Reference To The Literature 1bd3

Chain	Residue	Details
C	ARG104
C	ASP200
C	THR108

---

site_id	CSA4
Number of Residues	3
Details	Annotated By Reference To The Literature 1bd3

Chain	Residue	Details
D	ARG104
D	ASP200
D	THR108

---