1O5O
Crystal structure of Uracil phosphoribosyltransferase (TM0721) from Thermotoga maritima at 2.30 A resolution
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0004845 | molecular_function | uracil phosphoribosyltransferase activity |
| A | 0005525 | molecular_function | GTP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006223 | biological_process | uracil salvage |
| A | 0008655 | biological_process | pyrimidine-containing compound salvage |
| A | 0016757 | molecular_function | glycosyltransferase activity |
| A | 0044206 | biological_process | UMP salvage |
| B | 0000287 | molecular_function | magnesium ion binding |
| B | 0004845 | molecular_function | uracil phosphoribosyltransferase activity |
| B | 0005525 | molecular_function | GTP binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006223 | biological_process | uracil salvage |
| B | 0008655 | biological_process | pyrimidine-containing compound salvage |
| B | 0016757 | molecular_function | glycosyltransferase activity |
| B | 0044206 | biological_process | UMP salvage |
| C | 0000287 | molecular_function | magnesium ion binding |
| C | 0004845 | molecular_function | uracil phosphoribosyltransferase activity |
| C | 0005525 | molecular_function | GTP binding |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0006223 | biological_process | uracil salvage |
| C | 0008655 | biological_process | pyrimidine-containing compound salvage |
| C | 0016757 | molecular_function | glycosyltransferase activity |
| C | 0044206 | biological_process | UMP salvage |
| D | 0000287 | molecular_function | magnesium ion binding |
| D | 0004845 | molecular_function | uracil phosphoribosyltransferase activity |
| D | 0005525 | molecular_function | GTP binding |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0006223 | biological_process | uracil salvage |
| D | 0008655 | biological_process | pyrimidine-containing compound salvage |
| D | 0016757 | molecular_function | glycosyltransferase activity |
| D | 0044206 | biological_process | UMP salvage |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE SO4 A 701 |
| Chain | Residue |
| A | LEU78 |
| D | TYR115 |
| A | ARG79 |
| A | ALA80 |
| A | ILE102 |
| A | U5P600 |
| A | HOH753 |
| A | HOH754 |
| A | HOH756 |
| A | HOH757 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 B 702 |
| Chain | Residue |
| B | LEU78 |
| B | ARG79 |
| B | ALA80 |
| B | U5P601 |
| B | HOH768 |
| C | TYR115 |
| site_id | AC3 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE SO4 C 703 |
| Chain | Residue |
| B | TYR115 |
| C | LEU78 |
| C | ARG79 |
| C | ALA80 |
| C | U5P602 |
| C | HOH772 |
| C | HOH773 |
| C | HOH788 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 D 704 |
| Chain | Residue |
| A | TYR115 |
| D | ARG79 |
| D | ALA80 |
| D | U5P603 |
| D | HOH794 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 705 |
| Chain | Residue |
| A | ARG187 |
| A | ASN189 |
| A | ASP190 |
| A | HOH710 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 B 706 |
| Chain | Residue |
| B | ARG187 |
| B | ASN189 |
| B | ASP190 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 D 708 |
| Chain | Residue |
| D | ARG187 |
| D | ASN189 |
| D | ASP190 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 A 709 |
| Chain | Residue |
| A | GLY25 |
| A | PRO26 |
| A | ARG207 |
| A | HOH748 |
| A | HOH759 |
| D | LYS70 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 D 710 |
| Chain | Residue |
| A | LYS70 |
| D | GLY25 |
| D | PRO26 |
| D | ARG207 |
| D | HOH729 |
| site_id | BC1 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE U5P A 600 |
| Chain | Residue |
| A | ARG104 |
| A | MET133 |
| A | ALA135 |
| A | THR136 |
| A | GLY137 |
| A | VAL138 |
| A | SER139 |
| A | GLY192 |
| A | TYR193 |
| A | ILE194 |
| A | GLY199 |
| A | ASP200 |
| A | ALA201 |
| A | SO4701 |
| A | HOH712 |
| A | HOH737 |
| A | HOH754 |
| A | HOH755 |
| A | HOH756 |
| site_id | BC2 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE U5P B 601 |
| Chain | Residue |
| B | ARG104 |
| B | ASP131 |
| B | MET133 |
| B | ALA135 |
| B | THR136 |
| B | GLY137 |
| B | VAL138 |
| B | SER139 |
| B | GLY192 |
| B | TYR193 |
| B | ILE194 |
| B | GLY199 |
| B | ALA201 |
| B | SO4702 |
| B | HOH707 |
| B | HOH724 |
| B | HOH768 |
| B | HOH774 |
| site_id | BC3 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE U5P C 602 |
| Chain | Residue |
| C | ALA201 |
| C | SO4703 |
| C | HOH705 |
| C | HOH707 |
| C | HOH710 |
| C | HOH774 |
| C | HOH788 |
| C | ARG104 |
| C | MET133 |
| C | ALA135 |
| C | THR136 |
| C | GLY137 |
| C | VAL138 |
| C | SER139 |
| C | GLY192 |
| C | TYR193 |
| C | ILE194 |
| C | GLY199 |
| C | ASP200 |
| site_id | BC4 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE U5P D 603 |
| Chain | Residue |
| D | ARG104 |
| D | MET133 |
| D | ALA135 |
| D | THR136 |
| D | GLY137 |
| D | VAL138 |
| D | SER139 |
| D | GLY192 |
| D | TYR193 |
| D | ILE194 |
| D | GLY199 |
| D | ASP200 |
| D | ALA201 |
| D | SO4704 |
| D | HOH719 |
| D | HOH733 |
| D | HOH794 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 24 |
| Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_01218 |
| Chain | Residue | Details |
| C | ARG79 | |
| C | ARG104 | |
| C | ASP131 | |
| C | ILE194 | |
| C | GLY199 | |
| C | ASP200 | |
| D | ARG79 | |
| D | ARG104 | |
| D | ASP131 | |
| D | ILE194 | |
| D | GLY199 | |
| D | ASP200 | |
| A | ARG79 | |
| A | ARG104 | |
| A | ASP131 | |
| A | ILE194 | |
| A | GLY199 | |
| A | ASP200 | |
| B | ARG79 | |
| B | ARG104 | |
| B | ASP131 | |
| B | ILE194 | |
| B | GLY199 | |
| B | ASP200 |
