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1O5A

Dissecting and Designing Inhibitor Selectivity Determinants at the S1 site Using an Artificial Ala190 Protease (Ala190 uPA)

Functional Information from GO Data
ChainGOidnamespacecontents
B0004252molecular_functionserine-type endopeptidase activity
B0006508biological_processproteolysis
Functional Information from PDB Data
site_idAC1
Number of Residues17
DetailsBINDING SITE FOR RESIDUE 696 B 251
ChainResidue
BVAL41
BVAL213
BTRP215
BGLY216
BGLY219
BGLY226
BHOH320
BHOH343
BHOH346
BCYS42
BHIS57
BCYS58
BGLN185
BALA190
BCYS191
BGLN192
BSER195

site_idAC2
Number of Residues12
DetailsBINDING SITE FOR RESIDUE CIT B 2
ChainResidue
BARG36
BLYS82
BLYS110
BHIS165
BARG166
BTHR178
BARG230
BHOH305
BHOH367
BHOH368
BHOH389
BHOH410

Functional Information from PROSITE/UniProt
site_idPS00134
Number of Residues6
DetailsTRYPSIN_HIS Serine proteases, trypsin family, histidine active site. ISATHC
ChainResidueDetails
BILE53-CYS58

site_idPS00135
Number of Residues12
DetailsTRYPSIN_SER Serine proteases, trypsin family, serine active site. DAcqGDSGGPLV
ChainResidueDetails
BASP189-VAL200

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues3
DetailsACT_SITE: Charge relay system
ChainResidueDetails
BHIS57
BASP102
BSER195

site_idSWS_FT_FI2
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0000269|PubMed:9151681
ChainResidueDetails
BSER146

site_idSWS_FT_FI3
Number of Residues1
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine
ChainResidueDetails
BALA145

220113

PDB entries from 2024-05-22

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