1O57

CRYSTAL STRUCTURE OF THE PURINE OPERON REPRESSOR OF BACILLUS SUBTILIS

Replaces:  1P41

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0006351	biological_process	DNA-templated transcription
A	0006355	biological_process	regulation of DNA-templated transcription
A	0045892	biological_process	negative regulation of DNA-templated transcription
A	0045982	biological_process	negative regulation of purine nucleobase metabolic process
B	0003677	molecular_function	DNA binding
B	0006351	biological_process	DNA-templated transcription
B	0006355	biological_process	regulation of DNA-templated transcription
B	0045892	biological_process	negative regulation of DNA-templated transcription
B	0045982	biological_process	negative regulation of purine nucleobase metabolic process
C	0003677	molecular_function	DNA binding
C	0006351	biological_process	DNA-templated transcription
C	0006355	biological_process	regulation of DNA-templated transcription
C	0045892	biological_process	negative regulation of DNA-templated transcription
C	0045982	biological_process	negative regulation of purine nucleobase metabolic process
D	0003677	molecular_function	DNA binding
D	0006351	biological_process	DNA-templated transcription
D	0006355	biological_process	regulation of DNA-templated transcription
D	0045892	biological_process	negative regulation of DNA-templated transcription
D	0045982	biological_process	negative regulation of purine nucleobase metabolic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 A 581

Chain	Residue
A	GLY178
A	MET206
A	LYS207
A	ALA208
A	GLY209
A	GLY210
A	THR211
A	EPE570

---

site_id	AC2
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 B 582

Chain	Residue
B	MET206
B	LYS207
B	ALA208
B	GLY209
B	GLY210
B	THR211
B	HOH598
B	GLY178

---

site_id	AC3
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 C 583

Chain	Residue
C	SER177
C	GLY178
C	LYS207
C	ALA208
C	GLY209
C	GLY210
C	THR211
C	HOH636

---

site_id	AC4
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 D 584

Chain	Residue
D	SER177
D	GLY178
D	LYS207
D	ALA208
D	GLY209
D	GLY210
D	THR211
D	EPE571

---

site_id	AC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 B 586

Chain	Residue
A	ARG160
B	THR139
B	LYS140

---

site_id	AC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 C 587

Chain	Residue
C	THR139
C	LYS140
C	LYS161
C	HOH732
D	ARG160

---

site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 B 589

Chain	Residue
B	LYS2
B	ARG5
B	ARG8
B	HOH612

---

site_id	AC8
Number of Residues	10
Details	BINDING SITE FOR RESIDUE SO4 C 590

Chain	Residue
A	GLU245
A	HOH694
C	LYS2
C	PHE3
C	ARG4
C	ARG8
C	SER35
C	SER39
C	HOH603
C	HOH679

---

site_id	AC9
Number of Residues	9
Details	BINDING SITE FOR RESIDUE EPE A 570

Chain	Residue
A	THR139
A	LYS140
A	LYS161
A	ASP203
A	ASP204
A	PHE205
A	THR211
A	SO4581
B	ARG160

---

site_id	BC1
Number of Residues	10
Details	BINDING SITE FOR RESIDUE EPE D 571

Chain	Residue
D	THR139
D	LYS140
D	LYS161
D	ASP203
D	ASP204
D	PHE205
D	THR211
D	SO4584
D	HOH598
D	HOH653

---

site_id	BC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE P6G A 572

Chain	Residue
A	HIS21
A	LEU60
A	LYS70
A	ALA127
A	HOH594
A	HOH598
A	HOH602

---

site_id	BC3
Number of Residues	10
Details	BINDING SITE FOR RESIDUE P6G D 573

Chain	Residue
D	HIS21
D	LEU23
D	LEU60
D	LYS70
D	ALA127
D	GLU128
D	ARG129
D	GLU130
D	HOH600
D	HOH626

---

site_id	BC4
Number of Residues	17
Details	BINDING SITE FOR RESIDUE 2PE A 574

Chain	Residue
A	HOH585
B	PRO112
B	LEU115
B	SER116
B	TYR146
B	SER150
B	PG4575
B	HOH659
A	LEU17
A	PRO112
A	LEU115
A	SER116
A	PRO143
A	TYR146
A	ALA147
A	SER150
A	TYR151

---

site_id	BC5
Number of Residues	11
Details	BINDING SITE FOR RESIDUE PG4 B 575

Chain	Residue
A	LEU17
A	THR18
A	2PE574
B	LEU17
B	THR18
B	SER150
B	TYR151
B	HOH603
B	HOH613
B	HOH649
B	HOH659

---

site_id	BC6
Number of Residues	12
Details	BINDING SITE FOR RESIDUE 1PE C 576

Chain	Residue
C	LEU17
C	THR18
C	PRO112
C	LEU115
C	SER116
C	SER150
C	TYR151
C	HOH647
C	HOH686
D	TYR146
D	1PE577
D	HOH608

---

site_id	BC7
Number of Residues	10
Details	BINDING SITE FOR RESIDUE 1PE D 577

Chain	Residue
C	THR18
C	1PE576
C	HOH622
C	HOH647
D	LEU17
D	THR18
D	SER150
D	TYR151
D	HOH591
D	HOH608

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	24
Details	Binding site: {"evidences":[{"source":"PDB","id":"7RMW","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	32
Details	Binding site: {"evidences":[{"source":"PubMed","id":"12837784","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"1P4A","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Binding site: {"description":"covalent","evidences":[{"source":"PDB","id":"7RMW","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	144
Details	Region: {"description":"DNA binding domain","evidences":[{"source":"PubMed","id":"34967415","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

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