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1O0L

THE STRUCTURE OF BCL-W REVEALS A ROLE FOR THE C-TERMINAL RESIDUES IN MODULATING BIOLOGICAL ACTIVITY

Functional Information from GO Data
ChainGOidnamespacecontents
A0001836biological_processrelease of cytochrome c from mitochondria
A0002931biological_processresponse to ischemia
A0005515molecular_functionprotein binding
A0005739cellular_componentmitochondrion
A0005741cellular_componentmitochondrial outer membrane
A0005829cellular_componentcytosol
A0006915biological_processapoptotic process
A0007283biological_processspermatogenesis
A0008630biological_processintrinsic apoptotic signaling pathway in response to DNA damage
A0016020cellular_componentmembrane
A0031966cellular_componentmitochondrial membrane
A0035795biological_processnegative regulation of mitochondrial membrane permeability
A0042802molecular_functionidentical protein binding
A0042981biological_processregulation of apoptotic process
A0043066biological_processnegative regulation of apoptotic process
A0044877molecular_functionprotein-containing complex binding
A0051400molecular_functionBH domain binding
A0060011biological_processSertoli cell proliferation
A0071230biological_processcellular response to amino acid stimulus
A0071392biological_processcellular response to estradiol stimulus
A0090201biological_processnegative regulation of release of cytochrome c from mitochondria
A0097136cellular_componentBcl-2 family protein complex
A0097192biological_processextrinsic apoptotic signaling pathway in absence of ligand
A0097718molecular_functiondisordered domain specific binding
A1904646biological_processcellular response to amyloid-beta
A1905430biological_processcellular response to glycine
Functional Information from PROSITE/UniProt
site_idPS01080
Number of Residues20
DetailsBH1 Apoptosis regulator, Bcl-2 family BH1 motif signature. ELfQGgpNWGRLVAFFvFGA
ChainResidueDetails
AGLU85-ALA104

site_idPS01258
Number of Residues12
DetailsBH2 Apoptosis regulator, Bcl-2 family BH2 motif signature. WIhssGGWAeFT
ChainResidueDetails
ATRP137-THR148

site_idPS01260
Number of Residues21
DetailsBH4_1 Apoptosis regulator, Bcl-2 family BH4 motif signature. DTRALVaDFVGYKLRQKGYvC
ChainResidueDetails
AASP9-CYS29

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsMOD_RES: N-acetylalanine => ECO:0007744|PubMed:19413330
ChainResidueDetails
AALA2

223790

PDB entries from 2024-08-14

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