1O0L
THE STRUCTURE OF BCL-W REVEALS A ROLE FOR THE C-TERMINAL RESIDUES IN MODULATING BIOLOGICAL ACTIVITY
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001836 | biological_process | release of cytochrome c from mitochondria |
| A | 0003006 | biological_process | developmental process involved in reproduction |
| A | 0005515 | molecular_function | protein binding |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0005741 | cellular_component | mitochondrial outer membrane |
| A | 0005829 | cellular_component | cytosol |
| A | 0006915 | biological_process | apoptotic process |
| A | 0007283 | biological_process | spermatogenesis |
| A | 0008630 | biological_process | intrinsic apoptotic signaling pathway in response to DNA damage |
| A | 0015267 | molecular_function | channel activity |
| A | 0031966 | cellular_component | mitochondrial membrane |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0042981 | biological_process | regulation of apoptotic process |
| A | 0043065 | biological_process | positive regulation of apoptotic process |
| A | 0043066 | biological_process | negative regulation of apoptotic process |
| A | 0055085 | biological_process | transmembrane transport |
| A | 0097136 | cellular_component | Bcl-2 family protein complex |
| A | 0097192 | biological_process | extrinsic apoptotic signaling pathway in absence of ligand |
| A | 0097718 | molecular_function | disordered domain specific binding |
Functional Information from PROSITE/UniProt
| site_id | PS01080 |
| Number of Residues | 20 |
| Details | BH1 Apoptosis regulator, Bcl-2 family BH1 motif signature. ELfQGgpNWGRLVAFFvFGA |
| Chain | Residue | Details |
| A | GLU85-ALA104 |
| site_id | PS01258 |
| Number of Residues | 12 |
| Details | BH2 Apoptosis regulator, Bcl-2 family BH2 motif signature. WIhssGGWAeFT |
| Chain | Residue | Details |
| A | TRP137-THR148 |
| site_id | PS01260 |
| Number of Residues | 21 |
| Details | BH4_1 Apoptosis regulator, Bcl-2 family BH4 motif signature. DTRALVaDFVGYKLRQKGYvC |
| Chain | Residue | Details |
| A | ASP9-CYS29 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 20 |
| Details | Motif: {"description":"BH4"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 19 |
| Details | Motif: {"description":"BH1"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 15 |
| Details | Motif: {"description":"BH2"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"N-acetylalanine","evidences":[{"source":"PubMed","id":"19413330","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
