1NYR
Structure of Staphylococcus aureus threonyl-tRNA synthetase complexed with ATP
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000049 | molecular_function | tRNA binding |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0003723 | molecular_function | RNA binding |
| A | 0004812 | molecular_function | aminoacyl-tRNA ligase activity |
| A | 0004829 | molecular_function | threonine-tRNA ligase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006412 | biological_process | translation |
| A | 0006418 | biological_process | tRNA aminoacylation for protein translation |
| A | 0006435 | biological_process | threonyl-tRNA aminoacylation |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016874 | molecular_function | ligase activity |
| A | 0043039 | biological_process | tRNA aminoacylation |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0140096 | molecular_function | catalytic activity, acting on a protein |
| A | 0140101 | molecular_function | catalytic activity, acting on a tRNA |
| B | 0000049 | molecular_function | tRNA binding |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0003723 | molecular_function | RNA binding |
| B | 0004812 | molecular_function | aminoacyl-tRNA ligase activity |
| B | 0004829 | molecular_function | threonine-tRNA ligase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006412 | biological_process | translation |
| B | 0006418 | biological_process | tRNA aminoacylation for protein translation |
| B | 0006435 | biological_process | threonyl-tRNA aminoacylation |
| B | 0016740 | molecular_function | transferase activity |
| B | 0016874 | molecular_function | ligase activity |
| B | 0043039 | biological_process | tRNA aminoacylation |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0140096 | molecular_function | catalytic activity, acting on a protein |
| B | 0140101 | molecular_function | catalytic activity, acting on a tRNA |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 1001 |
| Chain | Residue |
| A | CYS336 |
| A | HIS387 |
| A | HIS517 |
| A | THR1004 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 1002 |
| Chain | Residue |
| A | HIS75 |
| A | HIS79 |
| A | CYS181 |
| A | HIS185 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN B 2001 |
| Chain | Residue |
| B | HIS387 |
| B | HIS517 |
| B | THR2004 |
| B | CYS336 |
| site_id | AC4 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE ATP A 1003 |
| Chain | Residue |
| A | ARG365 |
| A | GLU367 |
| A | ARG377 |
| A | VAL378 |
| A | MET381 |
| A | LEU383 |
| A | LYS471 |
| A | THR485 |
| A | LEU486 |
| A | GLN490 |
| A | SER522 |
| A | THR523 |
| A | ARG526 |
| A | THR1004 |
| A | HOH1112 |
| site_id | AC5 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE THR A 1004 |
| Chain | Residue |
| A | MET334 |
| A | ASN335 |
| A | CYS336 |
| A | ARG365 |
| A | ASP385 |
| A | HIS387 |
| A | GLN490 |
| A | HIS517 |
| A | ZN1001 |
| A | ATP1003 |
| site_id | AC6 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE ATP B 2003 |
| Chain | Residue |
| B | TYR313 |
| B | MET363 |
| B | ARG365 |
| B | GLU367 |
| B | GLN376 |
| B | ARG377 |
| B | VAL378 |
| B | MET381 |
| B | GLU464 |
| B | THR485 |
| B | SER522 |
| B | THR523 |
| B | ARG526 |
| B | THR2004 |
| B | HOH2068 |
| site_id | AC7 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE THR B 2004 |
| Chain | Residue |
| B | MET334 |
| B | CYS336 |
| B | ASP385 |
| B | HIS387 |
| B | TYR468 |
| B | GLN490 |
| B | HIS517 |
| B | ZN2001 |
| B | ATP2003 |
| B | HOH2016 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 160 |
| Details | Region: {"description":"N2 domain","evidences":[{"source":"PubMed","id":"12875846","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 596 |
| Details | Region: {"description":"Catalytic","evidences":[{"source":"PubMed","id":"12875846","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 208 |
| Details | Region: {"description":"Anticodon recognition","evidences":[{"source":"PubMed","id":"12875846","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00184","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"12875846","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 12 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"12875846","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 62 |
| Details | Domain: {"description":"TGS","evidences":[{"source":"PROSITE-ProRule","id":"PRU01228","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 61 |
| Details | Region: {"description":"N1 domain","evidences":[{"source":"PubMed","id":"12875846","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1qf6 |
| Chain | Residue | Details |
| A | ARG365 |
| site_id | CSA2 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1qf6 |
| Chain | Residue | Details |
| B | ARG365 |
