1NX1

Calpain Domain VI Complexed with Calpastatin Inhibitory Domain C (DIC)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005509	molecular_function	calcium ion binding
B	0005509	molecular_function	calcium ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA A 1

Chain	Residue
A	GLY108
A	ASP110
A	GLU112
A	GLU117
A	LYS156
A	HOH972

---

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA A 2

Chain	Residue
A	LYS156
A	GLU161
A	HOH959
A	ASP150
A	ASP152
A	THR154

---

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA A 3

Chain	Residue
A	ASP180
A	ASP182
A	SER184
A	THR186
A	HOH923
A	HOH980

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CA A 4

Chain	Residue
A	ASP135
A	ASP223
A	ASP225
A	ASN226

---

site_id	AC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA B 5

Chain	Residue
B	GLY408
B	ASP410
B	GLU412
B	GLU417
B	LYS456

---

site_id	AC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA B 6

Chain	Residue
B	ASP450
B	ASP452
B	THR454
B	LYS456
B	GLU461
B	HOH931

---

site_id	AC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA B 7

Chain	Residue
B	ASP480
B	ASP482
B	SER484
B	THR486
B	GLY488
B	GLU491

---

site_id	AC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CA B 8

Chain	Residue
B	ASP435
B	ASP523
B	ASP525
B	ASN526

---

site_id	AC9
Number of Residues	17
Details	BINDING SITE FOR CHAIN C OF CALPASTATIN

Chain	Residue
A	LEU102
A	LEU106
A	ARG128
A	HIS129
A	TRP166
A	GLN173
A	ALA174
A	LYS177
A	GLU197
A	HOH944
C	HOH914
C	HOH918
C	HOH926
C	HOH956
C	HOH985
C	HOH994
C	HOH1002

---

site_id	BC1
Number of Residues	12
Details	BINDING SITE FOR CHAIN D OF CALPASTATIN

Chain	Residue
B	LEU402
B	LEU406
B	ILE421
B	VAL425
B	ARG428
B	HIS429
B	TRP466
B	GLN473
B	ALA474
B	LYS477
B	HOH973
D	HOH941

---

Functional Information from PROSITE/UniProt

site_id	PS00018
Number of Residues	13
Details	EF_HAND_1 EF-hand calcium-binding domain. DSDTTGKLGfeEF

Chain	Residue	Details
A	ASP150-PHE162
A	ASP180-LEU192

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	68
Details	Domain: {"description":"EF-hand 1; atypical","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	66
Details	Domain: {"description":"EF-hand 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	70
Details	Domain: {"description":"EF-hand 3","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	56
Details	Domain: {"description":"EF-hand 4","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	68
Details	Domain: {"description":"EF-hand 5","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"Q64537","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"Q64537","evidenceCode":"ECO:0000250"},{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	2
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"P04632","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---