Functional Information from GO Data
| Chain | GOid | namespace | contents |
| B | 0004197 | molecular_function | cysteine-type endopeptidase activity |
| B | 0006508 | biological_process | proteolysis |
| B | 0008234 | molecular_function | cysteine-type peptidase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 501 |
| Chain | Residue |
| A | CYS300 |
| A | CYS303 |
| A | HIS320 |
| A | CYS327 |
Functional Information from PROSITE/UniProt
| site_id | PS01121 |
| Number of Residues | 15 |
| Details | CASPASE_HIS Caspase family histidine active site. HgaldCcvVvILSHG |
| Chain | Residue | Details |
| B | HIS224-GLY238 | |
| site_id | PS01122 |
| Number of Residues | 12 |
| Details | CASPASE_CYS Caspase family cysteine active site. KPKLFFIQACGG |
| Chain | Residue | Details |
| B | LYS278-GLY289 | |
| site_id | PS01282 |
| Number of Residues | 66 |
| Details | BIR_REPEAT_1 BIR repeat. YeaRiftfgt.Wiysvnkeqlar...AGFyAlgegDkvkCfhCgggltdWkpsedpweqHakwyPgCkyL |
| Chain | Residue | Details |
| A | TYR265-LEU330 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 65 |
| Details | Repeat: {"description":"BIR 3"} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 15 |
| Details | Region: {"description":"Required for interaction with SEPTIN4 isoform ARTS","evidences":[{"source":"PubMed","id":"21695558","evidenceCode":"ECO:0000269"}]} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00029","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI4 |
| Number of Residues | 3 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"12747801","evidenceCode":"ECO:0000269"}]} |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Active site: {"evidences":[{"evidenceCode":"ECO:0000250"}]} |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphotyrosine; by ABL1","evidences":[{"source":"PubMed","id":"15657060","evidenceCode":"ECO:0000269"}]} |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"(Microbial infection) ADP-riboxanated arginine","evidences":[{"source":"PubMed","id":"35338844","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35446120","evidenceCode":"ECO:0000269"}]} |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 5 |
| Details | a catalytic site defined by CSA, PubMed 10745077, 10578173 |
| Chain | Residue | Details |
| B | CYS287 | |
| B | CYS287 | |
| B | GLY238 | |
| B | HIS237 | |
| B | ARG178 | |
| site_id | MCSA1 |
| Number of Residues | 4 |
| Details | M-CSA 816 |
| Chain | Residue | Details |
| B | ARG178 | electrostatic stabiliser |
| B | HIS237 | proton acceptor, proton donor |
| B | GLY238 | electrostatic stabiliser |
| B | CYS287 | nucleofuge, nucleophile, proton acceptor, proton donor |
