1NUT

CRYSTAL STRUCTURE OF HUMAN CYTOSOLIC NMN/NaMN ADENYLYLTRANSFERASE COMPLEXED WITH ATP ANALOG

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0000309	molecular_function	nicotinamide-nucleotide adenylyltransferase activity
A	0003824	molecular_function	catalytic activity
A	0004515	molecular_function	nicotinate-nucleotide adenylyltransferase activity
A	0005524	molecular_function	ATP binding
A	0005739	cellular_component	mitochondrion
A	0005759	cellular_component	mitochondrial matrix
A	0009058	biological_process	biosynthetic process
A	0009165	biological_process	nucleotide biosynthetic process
A	0009435	biological_process	NAD+ biosynthetic process
A	0016740	molecular_function	transferase activity
A	0016779	molecular_function	nucleotidyltransferase activity
A	0019363	biological_process	pyridine nucleotide biosynthetic process
A	0030424	cellular_component	axon
A	0034355	biological_process	NAD+ biosynthetic process via the salvage pathway
A	0034612	biological_process	response to tumor necrosis factor
A	0043025	cellular_component	neuronal cell body
A	0070566	molecular_function	adenylyltransferase activity
B	0000166	molecular_function	nucleotide binding
B	0000309	molecular_function	nicotinamide-nucleotide adenylyltransferase activity
B	0003824	molecular_function	catalytic activity
B	0004515	molecular_function	nicotinate-nucleotide adenylyltransferase activity
B	0005524	molecular_function	ATP binding
B	0005739	cellular_component	mitochondrion
B	0005759	cellular_component	mitochondrial matrix
B	0009058	biological_process	biosynthetic process
B	0009165	biological_process	nucleotide biosynthetic process
B	0009435	biological_process	NAD+ biosynthetic process
B	0016740	molecular_function	transferase activity
B	0016779	molecular_function	nucleotidyltransferase activity
B	0019363	biological_process	pyridine nucleotide biosynthetic process
B	0030424	cellular_component	axon
B	0034355	biological_process	NAD+ biosynthetic process via the salvage pathway
B	0034612	biological_process	response to tumor necrosis factor
B	0043025	cellular_component	neuronal cell body
B	0070566	molecular_function	adenylyltransferase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A 301

Chain	Residue
A	LYS95
A	ARG98
A	HIS152

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site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 B 302

Chain	Residue
B	LYS95
B	ARG98
B	LYS149
B	HIS152

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site_id	AC3
Number of Residues	22
Details	BINDING SITE FOR RESIDUE APC A 401

Chain	Residue
A	PHE15
A	MET21
A	HIS22
A	LYS56
A	CYS134
A	GLY135
A	ASP137
A	ARG167
A	ASN198
A	ALA202
A	THR203
A	ARG206
A	HOH519
A	HOH560
A	HOH623
A	HOH636
A	HOH643
A	HOH719
B	LYS140
B	HOH738
A	GLY13
A	SER14

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site_id	AC4
Number of Residues	20
Details	BINDING SITE FOR RESIDUE APC B 402

Chain	Residue
A	LYS140
B	GLY13
B	SER14
B	PHE15
B	MET21
B	HIS22
B	CYS134
B	GLY135
B	ASP137
B	VAL138
B	ARG167
B	ASN198
B	ILE200
B	ALA202
B	THR203
B	ARG206
B	HOH509
B	HOH575
B	HOH605
B	HOH613

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	20
Details	Binding site: {"evidences":[{"source":"PubMed","id":"12574164","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1NUU","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	10
Details	Binding site: {"description":"in other chain","evidences":[{"source":"PubMed","id":"12574164","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"12574164","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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