Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004252 | molecular_function | serine-type endopeptidase activity |
| A | 0005576 | cellular_component | extracellular region |
| A | 0006508 | biological_process | proteolysis |
| A | 0007596 | biological_process | blood coagulation |
| B | 0004252 | molecular_function | serine-type endopeptidase activity |
| B | 0005509 | molecular_function | calcium ion binding |
| B | 0006508 | biological_process | proteolysis |
| B | 0007596 | biological_process | blood coagulation |
| E | 0004252 | molecular_function | serine-type endopeptidase activity |
| E | 0005576 | cellular_component | extracellular region |
| E | 0006508 | biological_process | proteolysis |
| E | 0007596 | biological_process | blood coagulation |
| F | 0004252 | molecular_function | serine-type endopeptidase activity |
| F | 0005509 | molecular_function | calcium ion binding |
| F | 0006508 | biological_process | proteolysis |
| F | 0007596 | biological_process | blood coagulation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE 0ZJ B 299 |
| Chain | Residue |
| B | HIS57 |
| B | GLY216 |
| B | GLY219 |
| B | GLY226 |
| B | HOH313 |
| B | HOH462 |
| D | HG1003 |
| D | HG1004 |
| B | TRP60 |
| B | LEU99 |
| B | ASP189 |
| B | ALA190 |
| B | GLY193 |
| B | SER195 |
| B | SER214 |
| B | TRP215 |
| site_id | AC2 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE 0ZJ F 299 |
| Chain | Residue |
| F | HIS57 |
| F | TRP60 |
| F | LEU99 |
| F | ILE174 |
| F | ASP189 |
| F | ALA190 |
| F | GLU192 |
| F | GLY193 |
| F | SER195 |
| F | SER214 |
| F | TRP215 |
| F | GLY216 |
| F | GLY219 |
| F | GLY226 |
| F | HOH290 |
| H | HG1001 |
| H | HG1002 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE HG H 1001 |
| Chain | Residue |
| F | 0ZJ299 |
| H | ASP106 |
| H | HG1002 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE HG H 1002 |
| Chain | Residue |
| F | 0ZJ299 |
| H | ASP106 |
| H | HG1001 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE HG D 1003 |
| Chain | Residue |
| B | 0ZJ299 |
| D | ASP106 |
| D | HG1004 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE HG D 1004 |
| Chain | Residue |
| B | 0ZJ299 |
| D | ASP106 |
| D | HG1003 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE IMD H 2000 |
| Chain | Residue |
| D | TRP25 |
| H | TYR84 |
| H | LYS103 |
| site_id | AC8 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE IMD D 2001 |
| Chain | Residue |
| D | TYR84 |
| D | LYS103 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE IMD D 2003 |
| Chain | Residue |
| D | GLU219 |
| D | LYS233 |
| D | PRO234 |
| D | ASP235 |
| D | HOH2175 |
| site_id | BC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE IMD H 2004 |
| Chain | Residue |
| H | GLU219 |
| H | LYS233 |
| H | PRO234 |
Functional Information from PROSITE/UniProt
| site_id | PS00134 |
| Number of Residues | 6 |
| Details | TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. LTAAHC |
| Chain | Residue | Details |
| B | LEU53-CYS58 | |
| site_id | PS00135 |
| Number of Residues | 12 |
| Details | TRYPSIN_SER Serine proteases, trypsin family, serine active site. DAceGDSGGPFV |
| Chain | Residue | Details |
| B | ASP189-VAL200 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 6 |
| Details | ACT_SITE: Charge relay system |
| Chain | Residue | Details |
| B | HIS57 | |
| B | ASP102 | |
| B | SER195 | |
| F | HIS57 | |
| F | ASP102 | |
| F | SER195 | |
| Chain | Residue | Details |
| B | ASN60 | |
| F | ASN60 | |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| B | ASP102 | |
| B | SER195 | |
| B | GLY193 | |
| B | HIS57 | |
| site_id | CSA2 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| F | ASP102 | |
| F | SER195 | |
| F | GLY193 | |
| F | HIS57 | |
| site_id | CSA3 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| B | ASP102 | |
| B | SER195 | |
| B | HIS57 | |
| B | GLY196 | |
| site_id | CSA4 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| F | ASP102 | |
| F | SER195 | |
| F | HIS57 | |
| F | GLY196 | |
| site_id | CSA5 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| B | ASP102 | |
| B | SER195 | |
| B | HIS57 | |
| site_id | CSA6 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| F | ASP102 | |
| F | SER195 | |
| F | HIS57 | |
