Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

1NTO

N249Y MUTANT OF ALCOHOL DEHYDROGENASE FROM THE ARCHAEON SULFOLOBUS SOLFATARICUS-MONOCLINIC CRYSTAL FORM

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004022	molecular_function	alcohol dehydrogenase (NAD+) activity
A	0008270	molecular_function	zinc ion binding
A	0016491	molecular_function	oxidoreductase activity
A	0046872	molecular_function	metal ion binding
B	0004022	molecular_function	alcohol dehydrogenase (NAD+) activity
B	0008270	molecular_function	zinc ion binding
B	0016491	molecular_function	oxidoreductase activity
B	0046872	molecular_function	metal ion binding
C	0004022	molecular_function	alcohol dehydrogenase (NAD+) activity
C	0008270	molecular_function	zinc ion binding
C	0016491	molecular_function	oxidoreductase activity
C	0046872	molecular_function	metal ion binding
D	0004022	molecular_function	alcohol dehydrogenase (NAD+) activity
D	0008270	molecular_function	zinc ion binding
D	0016491	molecular_function	oxidoreductase activity
D	0046872	molecular_function	metal ion binding
E	0004022	molecular_function	alcohol dehydrogenase (NAD+) activity
E	0008270	molecular_function	zinc ion binding
E	0016491	molecular_function	oxidoreductase activity
E	0046872	molecular_function	metal ion binding
H	0004022	molecular_function	alcohol dehydrogenase (NAD+) activity
H	0008270	molecular_function	zinc ion binding
H	0016491	molecular_function	oxidoreductase activity
H	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 400

Chain	Residue
A	GLU98
A	CYS101
A	CYS104
A	CYS112

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 500

Chain	Residue
A	CYS38
A	HIS68
A	GLU69
A	CYS154

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 400

Chain	Residue
B	CYS101
B	CYS104
B	CYS112
B	GLU98

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 500

Chain	Residue
B	CYS38
B	HIS68
B	GLU69
B	CYS154

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN C 400

Chain	Residue
C	GLU98
C	CYS101
C	CYS104
C	CYS112

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN C 500

Chain	Residue
C	CYS38
C	HIS68
C	GLU69
C	CYS154

site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN D 400

Chain	Residue
D	GLU98
D	CYS101
D	CYS104
D	CYS112

site_id	AC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN D 500

Chain	Residue
D	CYS38
D	HIS68
D	GLU69
D	CYS154

site_id	AC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN E 400

Chain	Residue
E	GLU98
E	CYS101
E	CYS104
E	CYS112

site_id	BC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN E 500

Chain	Residue
E	CYS38
E	HIS68
E	GLU69
E	CYS154

site_id	BC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN H 400

Chain	Residue
H	GLU98
H	CYS101
H	CYS104
H	CYS112

site_id	BC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN H 500

Chain	Residue
H	CYS38
H	HIS68
H	GLU69
H	CYS154

Functional Information from PROSITE/UniProt

site_id	PS00059
Number of Residues	15
Details	ADH_ZINC Zinc-containing alcohol dehydrogenases signature. GHEiAGKieevGdeV

Chain	Residue	Details
A	GLY67-VAL81

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	42
Details	Binding site: {}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	12
Details	Modified residue: {"description":"N6-methyllysine; partial","evidences":[{"source":"PubMed","id":"1463738","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 1teh

Chain	Residue	Details
A	SER40
A	HIS39

site_id	CSA10
Number of Residues	1
Details	Annotated By Reference To The Literature 1teh

Chain	Residue	Details
D	PHE49

site_id	CSA11
Number of Residues	1
Details	Annotated By Reference To The Literature 1teh

Chain	Residue	Details
E	PHE49

site_id	CSA12
Number of Residues	1
Details	Annotated By Reference To The Literature 1teh

Chain	Residue	Details
H	PHE49

site_id	CSA13
Number of Residues	2
Details	Annotated By Reference To The Literature 1teh

Chain	Residue	Details
A	SER40
A	HIS43

site_id	CSA14
Number of Residues	2
Details	Annotated By Reference To The Literature 1teh

Chain	Residue	Details
B	SER40
B	HIS43

site_id	CSA15
Number of Residues	2
Details	Annotated By Reference To The Literature 1teh

Chain	Residue	Details
C	SER40
C	HIS43

site_id	CSA16
Number of Residues	2
Details	Annotated By Reference To The Literature 1teh

Chain	Residue	Details
D	SER40
D	HIS43

site_id	CSA17
Number of Residues	2
Details	Annotated By Reference To The Literature 1teh

Chain	Residue	Details
E	SER40
E	HIS43

site_id	CSA18
Number of Residues	2
Details	Annotated By Reference To The Literature 1teh

Chain	Residue	Details
H	SER40
H	HIS43

site_id	CSA2
Number of Residues	2
Details	Annotated By Reference To The Literature 1teh

Chain	Residue	Details
B	SER40
B	HIS39

site_id	CSA3
Number of Residues	2
Details	Annotated By Reference To The Literature 1teh

Chain	Residue	Details
C	SER40
C	HIS39

site_id	CSA4
Number of Residues	2
Details	Annotated By Reference To The Literature 1teh

Chain	Residue	Details
D	SER40
D	HIS39

site_id	CSA5
Number of Residues	2
Details	Annotated By Reference To The Literature 1teh

Chain	Residue	Details
E	SER40
E	HIS39

site_id	CSA6
Number of Residues	2
Details	Annotated By Reference To The Literature 1teh

Chain	Residue	Details
H	SER40
H	HIS39

site_id	CSA7
Number of Residues	1
Details	Annotated By Reference To The Literature 1teh

Chain	Residue	Details
A	PHE49

site_id	CSA8
Number of Residues	1
Details	Annotated By Reference To The Literature 1teh

Chain	Residue	Details
B	PHE49

site_id	CSA9
Number of Residues	1
Details	Annotated By Reference To The Literature 1teh

Chain	Residue	Details
C	PHE49

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)