1NSF

D2 HEXAMERIZATION DOMAIN OF N-ETHYLMALEIMIDE SENSITIVE FACTOR (NSF)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005524	molecular_function	ATP binding
A	0016887	molecular_function	ATP hydrolysis activity
A	0035494	biological_process	SNARE complex disassembly

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG A 859

Chain	Residue
A	THR550
A	ATP858
A	HOH889
A	HOH890
A	HOH891

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site_id	AC2
Number of Residues	27
Details	BINDING SITE FOR RESIDUE ATP A 858

Chain	Residue
A	ILE508
A	VAL514
A	PRO545
A	HIS546
A	SER547
A	GLY548
A	LYS549
A	THR550
A	ALA551
A	LEU552
A	LYS631
A	SER647
A	ILE707
A	LYS708
A	LEU711
A	MG859
A	HOH863
A	HOH889
A	HOH890
A	HOH903
A	HOH919
A	HOH931
A	HOH959
A	ILE503
A	ASN505
A	GLY506
A	ILE507

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269|PubMed:9731775, ECO:0000305|PubMed:9727495

Chain	Residue	Details
A	ASN505
A	PRO545

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site_id	SWS_FT_FI2
Number of Residues	1
Details	BINDING: BINDING => ECO:0000269|PubMed:9731775

Chain	Residue	Details
A	THR550

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site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: Phosphoserine; by CDK16 => ECO:0000250|UniProtKB:P46460

Chain	Residue	Details
A	SER569

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Catalytic Information from CSA

site_id	MCSA1
Number of Residues	6
Details	M-CSA 642

Chain	Residue	Details
A	LYS549	electrostatic stabiliser
A	THR550	electrostatic stabiliser
A	ASP603	electrostatic stabiliser
A	ASP604	proton acceptor
A	LYS631	electrostatic stabiliser
A	LYS708	electrostatic stabiliser

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