1NSC

INFLUENZA B VIRUS NEURAMINIDASE CAN SYNTHESIZE ITS OWN INHIBITOR

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004308	molecular_function	exo-alpha-sialidase activity
A	0005975	biological_process	carbohydrate metabolic process
A	0016020	cellular_component	membrane
A	0033644	cellular_component	host cell membrane
A	0046761	biological_process	viral budding from plasma membrane
A	0055036	cellular_component	virion membrane
B	0004308	molecular_function	exo-alpha-sialidase activity
B	0005975	biological_process	carbohydrate metabolic process
B	0016020	cellular_component	membrane
B	0033644	cellular_component	host cell membrane
B	0046761	biological_process	viral budding from plasma membrane
B	0055036	cellular_component	virion membrane

Functional Information from PDB Data

site_id	CHA
Number of Residues	5
Details	HIGH-AFFINITY CALCIUM-BINDING SITES

Chain	Residue
A	ASP323
A	GLY343
A	GLY345
A	THR296
A	ASP292

---

site_id	CHB
Number of Residues	5
Details	HIGH-AFFINITY CALCIUM-BINDING SITES

Chain	Residue
B	ASP323
B	GLY343
B	GLY345
B	THR296
B	ASP292

---

site_id	CLA
Number of Residues	1
Details	LOW-AFFINITY CALCIUM-BINDING SITES

Chain	Residue
A	GLU167

---

site_id	CLB
Number of Residues	1
Details	LOW-AFFINITY CALCIUM-BINDING SITES

Chain	Residue
B	GLU167

---

site_id	SIA
Number of Residues	10
Details	ACTIVE SITE

Chain	Residue
A	ARG149
A	ILE220
A	ARG222
A	TRP176
A	GLU274
A	ASP148
A	TYR408
A	ASP323
A	ARG115
A	ARG291

---

site_id	SIB
Number of Residues	10
Details	ACTIVE SITE

Chain	Residue
B	ASP323
B	ARG115
B	ARG291
B	ARG149
B	ILE220
B	ARG222
B	TRP176
B	GLU274
B	ASP148
B	TYR408

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	ACT_SITE: Proton donor/acceptor => ECO:0000255|HAMAP-Rule:MF_04071

Chain	Residue	Details
A	ASP148
B	ASP148

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	ACT_SITE: Nucleophile => ECO:0000255|HAMAP-Rule:MF_04071

Chain	Residue	Details
A	TYR408
B	TYR408

---

site_id	SWS_FT_FI3
Number of Residues	10
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_04071

Chain	Residue	Details
A	ARG115
B	ARG373
A	ARG149
A	GLU274
A	ARG291
A	ARG373
B	ARG115
B	ARG149
B	GLU274
B	ARG291

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_04071, ECO:0000269|PubMed:1740114

Chain	Residue	Details
A	ASP292
A	ASP323
B	ASP292
B	ASP323

---

site_id	SWS_FT_FI5
Number of Residues	6
Details	BINDING: BINDING => ECO:0000269|PubMed:1740114

Chain	Residue	Details
A	THR296
A	GLY343
A	GLY345
B	THR296
B	GLY343
B	GLY345

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04071

Chain	Residue	Details
A	ASN143
B	ASN143

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04071, ECO:0000269|PubMed:1740114

Chain	Residue	Details
A	ASN283
B	ASN283

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 1a4g

Chain	Residue	Details
A	ASP148
A	GLU275

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site_id	CSA2
Number of Residues	2
Details	Annotated By Reference To The Literature 1a4g

Chain	Residue	Details
B	ASP148
B	GLU275

---